| Literature DB >> 35357670 |
Cristiano Spadaccio1,2, Antonio Nenna3, David Rose4, Francesco Piccirillo5, Annunziata Nusca5, Francesco Grigioni5, Massimo Chello3, Gus J Vlahakes6.
Abstract
Surgical myocardial revascularization is associated with long-term survival benefit in patients with multivessel coronary artery disease. However, the exact biological mechanisms underlying the clinical benefits of myocardial revascularization have not been elucidated yet. Angiogenesis and arteriogenesis biologically leading to vascular collateralization are considered one of the endogenous mechanisms to preserve myocardial viability during ischemia, and the presence of coronary collateralization has been regarded as one of the predictors of long-term survival in patients with coronary artery disease (CAD). Some experimental studies and indirect clinical evidence on chronic CAD confirmed an angiogenetic response induced by myocardial revascularization and suggested that revascularization procedures could constitute an angiogenetic trigger per se. In this review, the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both CAD and coronary revascularization is analyzed with the aim to better elucidate their significance in the clinical arena and potential therapeutic use.Entities:
Keywords: Angiogenesis; Arteriogenesis; Coronary artery bypass graft; Myocardial infarction; Myocardial revascularization; Percutaneous coronary intervention
Year: 2022 PMID： 35357670 DOI： 10.1007/s12265-022-10241-0
Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132