| Literature DB >> 35343053 |
Juliana Chen1,2,3, Harpreet Kaur2, Joanna Jaques1,2, Zoe Rock2, Catherine M Dean4, Reginald V Lord1,5, Veronica Preda1,2.
Abstract
Despite the obesity epidemic, there are relatively few multidisciplinary obesity services in Australia, and only limited data on the effectiveness of these services. The aim of this study was to evaluate the effectiveness of a university hospital-based weight management clinic-the 'Healthy Weight Clinic' in supporting patients to achieve clinically significant weight loss (≥5% reduction in body weight), weight maintenance, and changes in body composition. A retrospective review was conducted to determine weight and associated health outcomes in patients who attended an initial consultation in the first 2 years of the clinic-between March 2017 and March 2019. Follow up was at least 1 year for all patients. Patients who underwent bariatric surgery were excluded. Of 213 total patients, 172 patients attended more than one follow-up consultation for lifestyle modification. Mean weight change and percentage total weight change at last follow-up was -6.2 kg (SD 7.4) and - 6.0% (SD 6.9), respectively. For every additional clinic follow-up, there was 21.4% increased odds of achieving clinically significant weight loss, and for every additional month of follow-up, there was 10.1% increased odds of achieving clinically significant weight loss. Twenty percent of patients (34/172) maintained ≥5% of initial body weight loss for at least 1 year. Body composition measurements were also favourable, with significant changes in percentage skeletal muscle mass of +0.8% (SD 1.5) and in percentage fat mass by -1.4% (SD 3.2). Regular support in a structured holistic multidisciplinary obesity service enables patients to achieve clinically meaningful weight loss and improved skeletal muscle mass to body fat ratio, and maintain this loss for at least 1 year. Improved weight loss was associated with more patient visits and longer duration of attendance at the clinic.Entities:
Keywords: dietetics; endocrinology; exercise physiology; follow-up; integrated care; interdisciplinary health team; obesity
Mesh:
Year: 2022 PMID: 35343053 PMCID: PMC9285583 DOI: 10.1111/cob.12520
Source DB: PubMed Journal: Clin Obes ISSN: 1758-8103
Baseline characteristics of all patients, those who only attended the initial consultation and those who reattended the Healthy Weight Clinic
| Characteristics | All patients ( | Patients who only attended initial consultation ( | Patients who reattended the clinic ( |
|---|---|---|---|
| Gender | |||
| Female | 143 (67.1%) | 29 (70.7%) | 114 (66.3%) |
| Male | 70 (32.9%) | 12 (29.3%) | 58 (33.7%) |
| Mean age (years) | 51.3 (SD 15.0) | 51 (SD 15.1) | 51.8 (SD 14.9) |
| Anthropometric data | |||
| Mean weight (kg) | 104.9 (SD 20.4) | 103.9 (SD 20.4) | 105.1 (SD 20.5) |
| Mean BMI (kg/m2) |
37.3 (SD 6.8) Male: 37.2 (SD 5.8) Female: 37.3 (SD 7.3) |
37.3 (SD 7.7) Male: 34.9 (SD 5.7) Female: 38.3 (SD 8.2) |
37.2 (SD 6.6) Male: 37.7 (SD 5.7) Female: 37.3 (SD 7.3) |
| Mean excess weight (amount of weight over BMI 25 kg/m2) (kg) | 34.3 (SD 18.5) | 33.7 (SD 19.9) | 34.4 (SD 18.2) |
| Mean waist circumference (cm) |
115.5 (SD 15.5) Male: 125.0 (SD 15.8) Female: 110.9 (SD 13.1) |
114.7 (SD 12.3) Male: 117.9 (SD 8.6) Female: 113.3 (SD 13.7) |
115.7 (SD 16.2) Male: 126.5 (SD 16.6) Female: 110.9 (SD 13.1) |
| Smoking status | |||
| Never | 146 (68.5%) | 28 (68.3%) | 118 (68.6%) |
| Quit ≥10 years | 19 (8.9%) | 1 (2.4%) | 18 (10.5%) |
| Quit <10 years | 16 (7.5%) | 1 (2.4%) | 15 (8.7%) |
| Current | 10 (4.7%) | 3 (7.3%) | 7 (4.1%) |
| Unknown | 22 (10.3%) | 8 (19.5%) | 14 (8.1%) |
| Medical history | |||
| Pre‐diabetes | 44 (20.7%) | 3 (7.3%) | 41 (23.8%) |
| Insulin resistance | 44 (20.7%) | 6 (14.6%) | 38 (22.1%) |
| Type 2 diabetes | 27 (12.7%) | 3 (7.3%) | 24 (14.0%) |
| Dyslipidaemia | 83 (39.0%) | 12 (29.3%) | 71 (41.3%) |
| Hypertension | 72 (33.8%) | 14 (34.1%) | 58 (33.7%) |
| Joint and mobility pain | 75 (35.2%) | 12 (29.3%) | 63 (36.6%) |
| Chronic back pain | 36 (16.9%) | 6 (14.6%) | 30 (17.4%) |
| Osteoarthritis | 27 (12.7%) | 4 (9.8%) | 23 (13.4%) |
| Obstructive sleep apnoea | 50 (23.5%) | 11 (26.8%) | 39 (22.7%) |
| Depression | 39 (18.3%) | 7 (17.1%) | 32 (18.6%) |
| Non‐alcoholic fatty liver disease (NAFLD) | 37 (17.4%) | 3 (7.3%) | 34 (19.8%) |
| Ischaemic heart disease | 9 (4.2%) | 2 (4.9%) | 7 (4.1%) |
| Polycystic ovarian syndrome | 31 (14.6%) | 3 (7.3%) | 28 (16.3%) |
| Eating pattern | |||
| Emotional/stress eating | 57 (26.8%) | 14 (34.1%) | 43 (25%) |
| Boredom/mindless eating | 15 (7.0%) | 2 (4.9%) | 13 (7.6%) |
| Meal skipping (no binge style habits) | 23 (10.8%) | 2 (4.9%) | 21 (12.2%) |
| Binge eating (triggered by meal skipping) | 18 (8.5%) | 3 (7.3%) | 15 (8.7%) |
| Binge eating (emotional or stress induced) | 19 (8.9%) | 6 (14.6%) | 13 (7.6%) |
| Laboratory tests | |||
| Mean HbA1c (% and mmol/mol) |
5.80% (SD 1.1) 40 mmol/mol (SD −11.5) |
5.80 (SD 1.4) 40 mmol/mol (SD −8.19) |
5.80% (SD 1.1) 40 mmol/mol (SD −11.5) |
| Mean total cholesterol (mmol/L) | 5.11 (SD 1.17) | 5.50 (SD 1.0) | 5.06 (SD 1.2) |
| Mean high‐density lipoprotein (mmol/L) | 1.29 (SD 0.35) | 1.29 (SD 0.35) | 1.29 (SD 0.4) |
| Mean low‐density lipoprotein (mmol/L) | 3.11 (SD 1.09) | 2.79 (SD 1.0) | 3.17 (SD 1.1) |
| Mean triglycerides (mmol/L) | 1.50 (SD 0.71) | 1.51 (SD 0.64) | 1.50 (SD 0.7) |
| Pharmacotherapy (including in combination) | |||
| Metformin | 154 (72.3%) | 24 (58.5%) | 130 (75.6%) |
| Liraglutide | 69 (32.4%) | 11 (26.8%) | 58 (33.7%) |
| Dulaglutide | 7 (3.3%) | 0 (0%) | 7 (4.1%) |
| Duromine | 26 (12.2%) | 3 (7.3%) | 23 (13.4%) |
| Orlistat | 10 (4.7%) | 0 (0%) | 10 (5.8%) |
| Contrave | 2 (0.9%) | 0 (0%) | 2 (1.2%) |
| Length of clinic follow‐up | |||
| Did not return | 41 (19.2%) | 41 (100%) | 0 (0%) |
| 1–2 months | 42 (19.7%) | N/A | 42 (24.4%) |
| 3–5 months | 30 (14.1%) | N/A | 30 (17.4%) |
| 6–8 months | 18 (8.5%) | N/A | 18 (10.5%) |
| 9–11 months | 21 (9.9%) | N/A | 21 (12.2%) |
| 12–18 months | 20 (9.4%) | N/A | 20 (11.6%) |
| 19–24 months | 22 (10.3%) | N/A | 22 (12.8%) |
| 25–36 months | 18 (8.5%) | N/A | 18 (10.5%) |
| >36 months | 1 (0.5%) | N/A | 1 (0.6%) |
| Number of patient visits to clinic | |||
| Only initial appointment | 41 (19.2%) | 41 (100%) | 0 (0%) |
| 1–4 follow‐up visits | 47 (22.1%) | N/A | 47 (27.3%) |
| 5–9 follow‐up visits | 66 (31.9%) | N/A | 66 (38.4%) |
| 10–14 follow‐up visits | 33 (15.5%) | N/A | 33 (19.2%) |
| 15–19 follow‐up visits | 17 (8.0%) | N/A | 17 (9.9%) |
| More than 20 follow‐up visits | 9 (4.2%) | N/A | 9 (5.2%) |
Weight and body composition changes for patients who reattended the clinic (n = 172)
| Outcome | Time point | ||||||
|---|---|---|---|---|---|---|---|
| At last follow up | Baseline to 3 months | 3–6 months | 6–9 months | 9–12 months | 12–24 months | 24–36 months | |
| Weight outcomes | |||||||
|
| 172 | 147 | 111 | 91 | 72 | 30 | 3 |
| Mean weight change, kg (SD) | −6.2 (7.4)* | −4.6 (4.5)* | −1.4 (2.9)* | −1.2 (2.7)* | −0.8 (1.9)* | −0.8 (5.6) | −3.5 (15.2) |
| Mean BMI change, kg/m2 (SD) | −2.3 (2.7)* | −1.7 (1.6)* | −0.5 (1.1)* | −0.5 (1.0)* | −0.3 (0.7)* | −0.3 (2.0) | −1.2 (5.8) |
| Mean percentage weight change, % (SD) | −6.0 (6.9)* | −4.3 (4.0) | −1.3 (2.9)* | −1.3 (2.8) | −0.9 (2.1) | −0.9 (5.5) | −4.2 (19.4) |
| Waist circumference outcome | |||||||
|
| 56 | 53 | 45 | 34 | 23 | 5 | 1 |
| Mean waist circumference change, cm (SD) | −6.9 (7.7)* | −3.9 (5.0)* | −2.2 (3.6)* | −1.3 (2.6)* | −1.2 (2.4)* | −5.1 (4.7) | −1.3 (N/A) |
| Body composition outcomes | |||||||
|
| 59 | 59 | 55 | 43 | 38 | 8 | 0 |
| Mean SMM change, kg (SD) | −0.6 (1.2)* | −0.4 (1.0)* | −0.1 (0.9) | −0.1 (0.9) | −0.2 (0.9) | −0.6 (1.0) | N/A |
| Mean percentage SMM change, % (SD) | 0.8 (1.5)* | 0.5 (1.1)* | 0.4 (1.1)* | 0.2 (1.1) | 0.2 (1.0) | −0.1 (1.1) | N/A |
| Mean FM change, kg (SD) | −3.7 (5.4)* | −2.5 (3.6)* | −1.5 (3.0)* | −0.7 (2.7) | −0.8 (2.2)* | −0.9 (4.0) | N/A |
| Mean percentage FM change, % (SD) | −1.4 (3.2)* | −0.9 (2.6)* | −0.8 (2.4)* | −0.2 (2.5) | −0.4 (2.3) | −0.5 (3.2) | N/A |
Note: *p value <.05 against baseline.
Abbreviations: FM, fat mass; N/A, not applicable; SMM, skeletal muscle mass.
FIGURE 1Percentage total body weight change according to the number of follow‐up visits with the clinic