| Literature DB >> 35323975 |
Gereon J Rieke1, Kathrin van Bremen1, Jenny Bischoff1, Michael ToVinh1, Malte B Monin1, Stefan Schlabe1,2, Jan Raabe1, Kim M Kaiser1, Claudia Finnemann1, Alexandru Odainic3,4, Anushka Kudaliyanage3, Eicke Latz3, Christian P Strassburg1, Christoph Boesecke1,2, Susanne V Schmidt3, Benjamin Krämer1, Jürgen K Rockstroh1,2, Jacob Nattermann1,2.
Abstract
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.Entities:
Keywords: ADCC; COVID-19; NK cell; mRNA vaccine
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Year: 2022 PMID： 35323975 PMCID： PMC8992321 DOI： 10.1093/infdis/jiac060
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226