| Literature DB >> 3532391 |
R D Gordon, J J Fung, B Markus, I Fox, S Iwatsuki, C O Esquivel, A Tzakis, S Todo, T E Starzl.
Abstract
Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antibody was associated with decreased patient or liver allograft survival for primary grafts or retransplants. Two patients have been given kidney transplants immediately after a liver allograft from a donor with whom each patient had an initial strongly positive donor-specific antibody crossmatch. The liver apparently removed or neutralized circulating anti-donor antibody, since the renal allografts functioned promptly and did not experience hyperacute rejection.Entities:
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Year: 1986 PMID: 3532391 PMCID: PMC3095820
Source DB: PubMed Journal: Surgery ISSN: 0039-6060 Impact factor: 3.982