Literature DB >> 35307855

Hyperphosphorylation tunes TDP-43 solubility.

Garrett M Ginell1,2, Alex S Holehouse1,2.   

Abstract

Post-translational modifications of intrinsically disordered regions (IDRs) enable changes in sequence chemistry, which in turn can tune conformational behavior and molecular interactions. In this issue of The EMBO Journal, Gruijs da Silva et al disentangle the effect of hyperphosphorylation on the C-terminal domain of TDP-43, a key IDR implicated in Amyotrophic Lateral Sclerosis (ALS).
© 2022 The Authors.

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Year:  2022        PMID： 35307855      PMCID： PMC9016343          DOI： 10.15252/embj.2022111062

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   14.012


  11 in total

1.  TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.

Authors:  Hao-Ru Li; Wan-Chin Chiang; Po-Chun Chou; Won-Jing Wang; Jie-Rong Huang
Journal:  J Biol Chem       Date:  2018-03-06       Impact factor: 5.157

2.  RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Authors:  Jacob R Mann; Amanda M Gleixner; Jocelyn C Mauna; Edward Gomes; Michael R DeChellis-Marks; Patrick G Needham; Katie E Copley; Bryan Hurtle; Bede Portz; Noah J Pyles; Lin Guo; Christopher B Calder; Zachary P Wills; Udai B Pandey; Julia K Kofler; Jeffrey L Brodsky; Amantha Thathiah; James Shorter; Christopher J Donnelly
Journal:  Neuron       Date:  2019-02-27       Impact factor: 17.173

3.  Hyperphosphorylation tunes TDP-43 solubility.

Authors:  Garrett M Ginell; Alex S Holehouse
Journal:  EMBO J       Date:  2022-03-21       Impact factor: 14.012

4.  ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.

Authors:  Alexander E Conicella; Gül H Zerze; Jeetain Mittal; Nicolas L Fawzi
Journal:  Structure       Date:  2016-08-18       Impact factor: 5.006

5.  Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.

Authors:  Amandine Molliex; Jamshid Temirov; Jihun Lee; Maura Coughlin; Anderson P Kanagaraj; Hong Joo Kim; Tanja Mittag; J Paul Taylor
Journal:  Cell       Date:  2015-09-24       Impact factor: 41.582

Review 6.  TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.

Authors:  Emma L Scotter; Han-Jou Chen; Christopher E Shaw
Journal:  Neurotherapeutics       Date:  2015-04       Impact factor: 7.620

7.  Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.

Authors:  Zachary Monahan; Veronica H Ryan; Abigail M Janke; Kathleen A Burke; Shannon N Rhoads; Gül H Zerze; Robert O'Meally; Gregory L Dignon; Alexander E Conicella; Wenwei Zheng; Robert B Best; Robert N Cole; Jeetain Mittal; Frank Shewmaker; Nicolas L Fawzi
Journal:  EMBO J       Date:  2017-08-08       Impact factor: 11.598

8.  TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.

Authors:  Jemeen Sreedharan; Ian P Blair; Vineeta B Tripathi; Xun Hu; Caroline Vance; Boris Rogelj; Steven Ackerley; Jennifer C Durnall; Kelly L Williams; Emanuele Buratti; Francisco Baralle; Jacqueline de Belleroche; J Douglas Mitchell; P Nigel Leigh; Ammar Al-Chalabi; Christopher C Miller; Garth Nicholson; Christopher E Shaw
Journal:  Science       Date:  2008-02-28       Impact factor: 47.728

9.  Phase separation-deficient TDP43 remains functional in splicing.

Authors:  Hermann Broder Schmidt; Ariana Barreau; Rajat Rohatgi
Journal:  Nat Commun       Date:  2019-10-25       Impact factor: 14.919

10.  Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.

Authors:  Lara A Gruijs da Silva; Francesca Simonetti; Saskia Hutten; Henrick Riemenschneider; Erin L Sternburg; Lisa M Pietrek; Jakob Gebel; Volker Dötsch; Dieter Edbauer; Gerhard Hummer; Lukas S Stelzl; Dorothee Dormann
Journal:  EMBO J       Date:  2022-02-03       Impact factor: 14.012
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  1 in total

1.  Hyperphosphorylation tunes TDP-43 solubility.

Authors:  Garrett M Ginell; Alex S Holehouse
Journal:  EMBO J       Date:  2022-03-21       Impact factor: 14.012
  1 in total

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