Barriers and Solutions to Improve Therapeutic Adherence from the Perspective of Primary Care and Hospital-Based Physicians.

Purpose: To identify the barriers affecting treatment adherence in patients with chronic disease and to determine solutions through the physician's opinion of primary care and hospital settings.
Methods: An observational study using the nominal group technique was performed to reach a consensus from experts. A structured face-to-face group discussion was carried out with physicians with more than 10 years of experience in the subject of treatment adherence/compliance in either the primary care setting or the hospital setting. The experts individually rated a list of questions using the Likert scale and prioritized the top 10 questions to identify barriers and seek solutions afterward. The top 10 questions that obtained the maximum score for both groups of experts were prioritized. During the final discussion group, participating experts analyzed the prioritized items and debated on each problem to reach consensual solutions for improvement.
Results: A total of 17 professionals experts participated in the study, nine of them were from a primary care setting. In the expert group from the primary care setting, the proposed solution for the barrier identified as the highest priority was to simplify treatments, measure adherence and review medication. In the expert group from the hospital setting, the proposed solution for the barrier identified as the highest priority was training on motivational clinical interviews for healthcare workers undergraduate and postgraduate education. Finally, the expert participants proposed implementing an improvement plan with eight key ideas.
Conclusion: A consensual improvement plan to facilitate the control of therapeutic adherence in patients with chronic disease was developed, taking into account expert physicians' opinions from primary care and hospital settings about barriers and solutions to address therapeutic adherence in patients with chronic disease.

Introduction

The concept of therapeutic adherence1 refers to the degree to which a person’s behavior, in terms of taking medication, following a diet, and making lifestyle changes, corresponds to the agreed upon recommendations of a healthcare provider. Poor therapeutic adherence occurs when there is no congruence between the above mentioned behavior of the person and the recommendations prescribed by the healthcare professional.2–4 This new term moves away from the paternalistic view of the relationship between the healthcare professional and the patient, associated with the concept of adherence, and includes the responsibility of the healthcare provider.

Currently, poor therapeutic adherence5,6 is the cause for the failure of many treatments, and entails serious problems in terms of quality of life for patients with chronic diseases, as well as costs for the healthcare system, also contributing to the failure to achieve positive clinical results.7 That is why the World Health Organization (WHO)7 considers poor therapeutic adherence and its negative clinical and economic consequences a top-priority issue in public health.

It is estimated that, in developed countries, the adherence rate for long-term treatments is 40–50%, while for short-term treatment it is 70–80%. Moreover, regarding health-dietary measures, the adherence rate is only 20–30%.4,8 In developing countries, it is assumed that the magnitude and impact of poor adherence are even greater, given the scarcity of healthcare resources and inequities in access to healthcare.3

Poor therapeutic adherence is a multidimensional phenomenon that is determined by five factors: socioeconomic factors, healthcare-system related factors, patient-related factors, treatment-related factors and disease-related factors.9,10 Overall, simple forgetfulness on the part of the patient is the most frequent cause of poor therapeutic adherence.8,11,12

Patient adherence with therapeutic regimens may be influenced by subjective beliefs about chronic disease.13,14 One of the challenges for healthcare professionals in improving adherence is to take into account the perception and knowledge that patients have about their disease and how well they understand the disease, with regard to both health education and medical treatment.

Assessment of therapeutic adherence is necessary for planning effective and efficient treatments. Haynes and Sackett1 were the first to study the concept of therapeutic adherence and its measurement. This was the starting point of this concept, as well as the interest in studying methods to quantify it. Since then, numerous methods for measuring adherence have been described in scientific literature, which can be classified as direct and indirect.3,7,8 Despite this, no measurement strategy has been considered optimal on its own, therefore multiple strategies that combine reasonable objective measures and self-reporting are required.

Poor therapeutic adherence is a serious problem for properly approaching chronic patients in our healthcare system.15 This is due to the existence of a series of barriers that healthcare professionals encounter in their daily clinical practice that make it difficult to integrate protocols for therapeutic adherence for patients with low or no adherence. Although the identification of barriers and possible solutions to treatment adherence have been the focus of many previous research studies, the management of non-adherence has not still been consensually defined.16 Previous qualitative studies have been carried out considering a specific condition or a stakeholder, such as patients, physicians, nurses or pharmacists. However, to explore the therapeutic adherence from the joint perspective of primary care physicians and hospital-based physicians could help to implement improvement plans aimed at facilitating the integration of adherence protocols between medical professionals. The present study aimed to identify the barriers that affect adherence in patients with chronic disease and to determine solutions from primary care and hospital settings.

Methods

This was an observational study using the nominal group technique17 as a qualitative research tool. This is a consensus method used in research to solve problems, create ideas and set priorities, and consists in a structured face-to-face group discussion with experts. The criteria for selecting the participating experts was to have more than 10 years of experience in the subject of treatment adherence/compliance in either the primary care setting or the hospital setting. Two groups of participants were formed: one group of primary care physicians (PCP) and a second group of specialists in cardiology, pulmonology, internal medicine, geriatrics, psychiatry, pain unit and clinical pharmacology. All professionals received an invitation letter and provided written consent before participating. This study was reviewed by the responsible research office of Miguel Hernandez University. Ethical approval was not required because patient data was not included in this study.

One researcher was the facilitator for discussion groups, ie the person who guided the group and ensured that the objectives of nominal group technique were met effectively. This qualitative study consisted of three discussion sessions on different days between November 2019 and January 2020: a first session with the PCP group, a second session with only hospital-based physicians (HBP) and, a third session with both groups of participants. In the first and second sessions, expert participants were invited to respond individually to a series of questions or items established by the research team. Individually and silently, each expert wrote their ideas about each question. For this, they had a maximum of 10 minutes. Then, each participant presented their ideas to the rest of the group (maximum 15 minutes per presentation) and all the members of the discussion group debated solutions. Finally, each expert rated the priorities and ideas. Discussions were held in Spanish language and no translation was needed. All the group discussions were recorded and transcribed by the researchers.

A questionnaire for the discussion group was developed by the research team using the most recent literature and the experience of the researchers. The proposed questionnaire consisted of 29 questions, divided into seven topics: General, Training, Patient, Structure and Healthcare, Treatments, Disease and Socio-health Environment (). The experts had to individually rate the proposed items and prioritize the top 10 questions to identify barriers and seek solutions afterward. In the event of a tie, the assessment was repeated. The highest rated proposals/ideas were selected in the end. The questions were rated using the Likert scale, with the participants giving each one a value ranging from “Not at all, disagree” = 1 point, to “Completely agree” = 5 points. The top 10 questions that obtained the maximum score for both groups of experts were prioritized.

In the third session, both PCPs and HBPs analyzed the items selected or prioritized by both groups of experts in the first two sessions, interacting in a structured debate on each individual problem that was prioritized, in order to reach consensual solutions or opportunities for improvement. Figure 1 shows how this nominal group session was conducted. This technique also took into account the minority positions. All the members of the groups participated, ensuring that the success of the ideas was not dependent on the overbearing presentation of a few members, thus promoting balance and seeking consensus.

Figure 1

Nominal group process.

Results

A total of 17 professionals participated in this study, of which nine were primary care physicians (PCP group) and eight were hospital-based physicians (HBP group). Tables 1 and 2 show the results of the prioritization of the 10 top-scoring questions out of the 29 questions raised (Annex 1) by the two groups of experts, in order to identify barriers. The maximum score that a question could receive for the PCP group was 45 points, since there were nine experts in the nominal group of primary care physicians; and the maximum score for the HBP group was 40, since this group had eight experts.

Table 1

Order of Priority of the Ten Highest Scoring Questions to Identify Barriers from the Primary Care Physician Group

Rank Order	Question	Points
1	[No. 22] Are polymedication and therapeutic complexity a cause of poor adherence in chronic patients?	42
2	[No. 16] Is a non-empathetic, poorly communicated interview with the patient a cause of poor adherence to treatment?	40
3	[No. 9] Is forgetfulness regarding taking medication a cause of poor adherence in chronic and elderly patients?	40
4	[No. 19] Is the lack of in-person time to explore patient adherence a cause of poor adherence?	40
5	[No. 27] Are the lack of correct understanding and perception of the disease and its treatment causes of poor adherence to treatment?	40
6	[No. 26] Are diseases with little or no symptomology a cause of poor adherence to treatment?	39
7	[No. 12] Is the lack of clear and simple information regarding the treatment instructions for the patient or their family a cause of poor adherence to treatment?	38
8	[No. 20] Are the high volume of patients and delay in appointments causes of poor adherence?	38
9	[No. 18] Is the healthcare professional’s lack of measuring adherence in clinical practice a cause of poor adherence to treatment?	36
10	[No. 21] Is not having a clinical practice action protocol for poor adherence to treatments a cause for not obtaining follow up with patients?	36

Table 2

Order of Priority of the Ten Highest Scoring Questions to Identify Barriers from the Hospital-Based Physician Group

Rank Order	Question	Points
1	[No. 16] Is a non-empathetic, poorly communicated interview with the patient a cause of poor adherence to treatment?	37
2	[No. 22] Are polymedication and therapeutic complexity a cause of poor adherence in chronic patients?	37
3	[No. 12] Is the lack of clear and simple information regarding the treatment instructions for the patient or their family a cause of poor adherence to treatment?	35
4	[No. 17] Is the lack of shared decision making a cause of poor adherence to treatment?	35
5	[No. 19] Is the lack of in-person time to explore patient adherence a cause of poor adherence?	35
6	[No. 26] Are diseases with little or no symptomology a cause of poor adherence to treatment?	33
7	[No. 27] Are the lack of correct understanding and perception of the disease and its treatment causes of poor adherence to treatment?	33
8	[No. 8] Are the patient’s lack of motivation or passive attitude about treatment causes for poor adherence?	33
9	[No. 10] Is the patient’s not knowing the aims of proper monitoring one of the reasons that treatment is not done correctly, and also a cause of poor adherence with therapeutic treatment?	32
10	[No. 21] Is not having a clinical practice action protocol for poor adherence to treatments a cause for not obtaining follow up with patients?	32

It is noteworthy that, in the PCP group, the highest score obtained was 42 points on question 22 (“Are polymedication and therapeutic complexity a cause of poor adherence in chronic patients?”) and the second place question was question 16 (“Is a non-empathetic, poorly communicated interview with the patient a cause of poor adherence to treatment?”) with 40 points; while in the HBP group, the first place question was question 16 with a score of 37 points, and second place was question 22, also with 37 points; although in the individual rating, the highest rated question was question 16. Three questions were identified as priority barriers only by the PCP group: question 9, from the Patient topic (“Is forgetfulness regarding taking medication a cause of poor adherence in chronic and elderly patients?”), and questions 20 (“Are the high volume of patients and delay in appointments causes of poor adherence?”) and 18 (“Is the healthcare professional’s lack of measuring adherence in clinical practice a cause of poor adherence to treatment?”), from the Healthcare Structure topic. Other three questions were identified as priority barriers only by the HBP group: questions 17 (“Is the lack of shared decision making a cause of poor adherence to treatment?”), 8 (“Are the patient’s lack of motivation or passive attitude about treatment causes for poor adherence?”) and 10

(Is the patient’s not knowing the aims of proper monitoring one of the reasons that treatment is not done correctly, and also a cause of poor adherence with therapeutic treatment?)

also from the Healthcare Structure and Patient topics (Tables 1 and 2). It is noteworthy that question 21 (“Is not having a clinical practice action protocol for poor adherence to treatments a cause for not obtaining follow up with patients?”), with 36 points in the PCP group and 32 points in the HBP group, was prioritized in last (tenth) place in both groups of experts.

The results obtained for identifying 10 barriers and 10 solutions prioritized by both groups of PCP and HBP experts are shown in Tables 3 and 4, in order starting with the highest score given on the questionnaire for identifying possible causes of poor therapeutic adherence. In the PCP group, the proposed solution for the barrier identified as the highest priority (question no. 22) was to simplify treatments, measure adherence and review medication (Table 3). In the HBP group, the proposed solution for the barrier identified as the highest priority (question no. 16) was training on motivational clinical interviews for healthcare workers undergraduate and postgraduate education (Table 4).

Table 3

Items Identified as Barriers and Their Solutions, Prioritized by Primary Care Physicians

Prioritized Barriers	Prioritized Solutions
1) [No. 22] Are polymedication and therapeutic complexity a cause of poor adherence in chronic patients?	Simplify treatments, review medication and measure adherenceCombination therapy (multiple medications in one pill) in treatments with fixed dosesDeprescribing, reviewing the treatment and objectivesPersonal dosing systems to prevent confusion of medications, or similar
2) [No. 16] Is a non-empathetic, poorly communicated interview with the patient a cause of poor adherence to treatment?	Motivational interviewsParticipation of the PCP team in managing the patient, including the community pharmacistTraining of professionals in managing non-adherent patientsEmpathy and ensuring that the patient has understood the indications given for their treatmentEducating the patient on managing their chronic disease
3) [No. 9] Is forgetfulness regarding taking medication a cause of poor adherence in chronic and elderly patients?	Involve the familyBehavioral reinforcementExpert proactive patientICT or pill reminder apps with alarmsWriting down medications and performing positive reinforcement
4) [No. 19] Is the lack of in-person time to explore patient adherence a cause of poor adherence?	Eliminate the bureaucracy of appointmentsTime management of the appointment by the professionalInclude the nurse and pharmacy in measuring adherenceAppointments scheduled specifically to measure adherence/compliance
5) [No. 27] Are the lack of correct understanding and perception of the disease and its treatment causes of poor adherence to treatment?	Use different communication techniques depending on the patientGood professional-patient relationship
6) [No. 26] Are diseases with little or no symptomology a cause of poor adherence to treatment?	Good doctor-patient relationshipEducate the patient on the process of their chronic disease
7) [No. 12] Is the lack of clear and simple information regarding the treatment instructions for the patient or their family a cause of poor adherence to treatment?	In both primary and secondary prevention, differentiate the start of treatment from monitoringAll professionals involved in the patient’s disease provide the same information to the patient and their caregiverProvide information in writing and involve the family
8) [No. 20] Are the high volume of patients and delay in appointments causes of poor adherence?	Teach healthcare professionals to manage appointments, as well as how to prioritize or limit themClinical management of appointments/clinical self-management in PCPAgreements between different levels of doctors regarding standard care
9) [No. 18] Is the healthcare professional’s lack of measuring adherence in clinical practice a cause of poor adherence to treatment?	Include a tool for measuring adherence in the electronic medical history chart
10) [No. 21] Is not having a clinical practice action protocol for poor adherence to treatments a cause for not obtaining follow up with patients?	Create a protocol that integrates all of the measures proposed at the meeting

Table 4

Items Identified as Barriers and Their Solutions, Prioritized by Hospital-Based Physicians

Prioritized Barriers	Prioritized Solutions
1) [No. 16] Is a non-empathetic, poorly communicated interview with the patient a cause of poor adherence to treatment?	Training on motivational clinical interviews for healthcare workers undergraduate and postgraduate educationEmpathize with the patient
2) [No. 22] Are polymedication and therapeutic complexity a cause of poor adherence in chronic patients?	Fixed dose combination therapyIt is the physician’s job to avoid the patient’s poor adherence in PCP, not the responsibility of commissions or work groups; these can cause more complications than they can helpWork as a team, including scientific societies that are likely to work on multidisciplinary teamsHave an action protocol in clinical practice for poor adherence to treatment, in order to properly monitor patientsMultidisciplinary teams that include the community pharmacy in measuring adherenceUse extended-release medications (less times per day)
3) [No. 12] Is the lack of clear and simple information regarding the treatment instructions for the patient or their family a cause of poor adherence to treatment?	Maintain the size and shape of the medicationPill dispensers (and virtual pill reminders)Personal dosing systemsIndicate on the electronic prescription to not change the size and shape of the medication
4) [No. 17] Is the lack of shared decision making a cause of poor adherence to treatment?	Negotiate the manner of taking the treatment with the patient, and follow upInvolve the family or caregiverBe empathetic with the patient and perform positive reinforcement regarding possible fears that their disease and treatment may cause
5) [No. 19] Is the lack of in-person time to explore patient adherence a cause of poor adherence?	Time management in appointmentsParticipation of patient associations and other professionals in trainingShort and clear messages to the patient about their medicationPlay informational videos about adherence in waiting rooms
6) [No. 26] Are diseases with little or no symptomology a cause of poor adherence to treatment?	Confirm proper adherence from the start of the treatmentFollow up conducted either by the nursing staff or the pharmacy
7) [No. 27] Are the lack of correct understanding and perception of the disease and its treatment causes of poor adherence to treatment?	Establish short-term goals and monitor treatmentInform a family member or caregiver about the treatmentKeep in mind: depression, cognitive impairment and dependence
8) [No. 8] Are the patient’s lack of motivation or passive attitude about treatment causes for poor adherence?	Motivational and behavioral interviewsInclude patient associations to motivate
9) [No. 10] Is the patient’s not knowing the aims of proper monitoring one of the reasons that treatment is not done correctly, and also a cause of poor adherence with therapeutic treatment?	Feasible, short-term goals (easy for the patient to achieve)Make an agreement with the patient regarding follow up goals after training from the professional
10) [No. 21] Is not having a clinical practice action protocol for poor adherence to treatments a cause for not obtaining follow up with patients?	Identify non-adherent patientsCheck if they picked up their medications from the pharmacyConduct a study to identify causes and establish intervention strategies

Finally, during the third session of nominal group, the expert participants proposed implementing an improvement plan with eight key ideas, in order to foster therapeutic adherence in patients with chronic diseases, from clinical practice. This plan was drawn up based on the barriers and solutions for better control of therapeutic adherence that were identified by the groups of primary care experts and hospital-based experts (Table 5).

Table 5

Improvement Plan: Facilitating Control of Therapeutic Adherence in Patients with Chronic Disease

1. Increase the level of knowledge and education of patients with chronic diseases so they can learn about caring for their health.

2. Promote the professional relationship between different levels of healthcare professionals to establish continuity of care that guarantees holistic attention for chronic health problems. This includes the use of new technologies to share experiences, protocols and types of interventions.

3. Involve the patient in the care process, informing them about the goals for controlling their illness, thus allowing them to adopt an active and committed attitude that aids in making shared decisions with the patient.

4. Undergraduate and postgraduate education in motivational clinical interviews for healthcare professionals (doctors, nurses, pharmacists, etc.).

5. Checking from the beginning of the treatment whether or not there is adherence, and undertaking monitoring that can also be performed by nursing staff or community pharmacy personnel.

6. Personal dosing systems.Indicate on the electronic prescription that there should be no changes in the size and shape of the medication.

7. Use multiple medications in one pill and fixed dose combination therapy.

8. Create a clinical algorithm based on the solutions obtained in this study to facilitate the management of therapeutic adherence.

Discussion

The present study allowed identifying barriers and solutions to address therapeutic adherence in patients with chronic disease from the perspective of primary care and hospital-based physicians. There were some differences between the results of the nominal group session with PCP and those of the session with only HBP. However, they managed to develop a consensual improvement plan to facilitate the control of therapeutic adherence in patients with chronic disease.

Regarding the obtained results, several issues were cause for great discussion in the meeting with both groups of experts. Question 9, “Is the healthcare professional’s lack of measuring adherence in clinical practice a cause of poor adherence to treatment?”, was in fourth place with 40 points in the PCP group, and was only identified by primary care professionals, possibly because hospital-based physicians have a different point of view of forgetfulness when it comes to taking medications. A systematic review published in 2018 by Zaugg et al,18 had the aim of evaluating the effects of providing doctors’ comments on adherence with medication to their patients to improve adherence, since it seems that, sometimes, hospital-based physicians tend to overestimate patients taking their medications as prescribed. This could lead to lost opportunities for changing medications, resolving side effects or proposing the use of reminders to improve adherence in patients. Therefore, doctors providing feedback on adherence with medications has the potential to bring about changes that improve patients’ adherence with prescribed medications. In general, primary care physicians have more feedback with their patients since they have longitudinal appointments over the life of the patient, taking into account their social environment, whether they live alone, whether the patient is socially fragile, etc., which means they have a more holistic point of view of the problem of poor adherence with long-term treatments.19,20

Forgetfulness is one of the largest causes for poor adherence, and there are many publications and clinical practice guides based on the evidence related to the topic of forgetfulness in poor adherence in chronic pathologies. Mahtani et al21 concluded that patients with chronic pathologies often do not take their medications properly due to forgetfulness, changes in the times at which the medication must be taken, or due to lifestyle. It is estimated that between 40% and 60% of people with chronic pathologies have at least some lack of adherence with their drug treatments, which can lead to worse health conditions.

The objective of the FOCUS22 study was to analyze the factors that interfere with correct adherence with cardiovascular treatments for secondary prevention after acute myocardial infarction. It concluded that the use of combination therapy (multiple medications in one pill) strategy fulfilled the principal evaluation criteria of adherence with secondary prevention after acute myocardial infarction.

The guide of the National Institute for Health and Clinical Excellence (NICE)23 recommends taking into account the patient’s wishes to take less medication, asking them about their concerns regarding the medication (side effects or risk of dependence), and talking to them about how to incorporate taking the medication into their daily lives.

Question 20, “Are the high volumes of patients and delay in appointments causes of poor adherence?”, was only prioritized by the PCP expert group, and the solution that they proposed is to teach healthcare professionals to properly manage and prioritize or limit appointments. They also suggested enhancing clinical management of appointments/clinical self-management in PCP and also creating agreements between different levels of doctors regarding standard care, based on patients with chronic pathologies. A study published in 2019 by Freixa-Pamias et al24 had the goal of analyzing a clinical management model which integrated cardiology and primary care in the clinical practice. In this new clinical management model with integrated attention, each cardiologist was assigned a primary care center and improved coordination was observed between the different levels of medical attention.

Question 18, “Is the healthcare professional’s lack of measuring adherence in clinical practice a cause of poor adherence to treatment?”, was only identified by the PCP group. The solution proposed by this group of experts is to include a tool for measuring adherence in electronic medical history charts. In a study conducted by Mabotuwana et al25 the objective of which was to analyze patterns in electronic prescriptions in electronic medical records and their capacity to detect cohorts of patients with significant adherence problems, it was observed that non-adherent patients, ie medication possession rate < 80% or lapse of > 30 days, are three times more likely to have poor control of their blood pressure goals. It was concluded that the development of a generic computerized framework of medical histories would be useful for formulating and consulting criteria based on long-term medication adherence issues. The levels of adherence observed indicated that a substantial proportion of patients classified with high blood pressure and diabetes had poor adherence associated with lower rates of blood pressure monitoring, which can be detected by an analysis of electronic prescriptions in computerized medical histories.

Question 17, “Is the lack of shared decision making a cause of poor adherence to treatment?”, was only identified by the HBP group. The solution they proposed is to negotiate the manner of taking the treatment with the patient, and follow up. They also suggested involving the family or caregiver, being empathetic with the patient and performing positive reinforcement regarding possible fears that their disease and treatment may cause (Table 4).

Question 21, “Is not having a clinical practice action protocol for poor adherence to treatments a cause for not obtaining follow up with patients?”, had 36 points in the PCP group and 32 points in the HBP group. Both groups selected this as a barrier. The solution proposed by the hospital experts is to identify non-compliant or non-adherent patients based on whether or not they picked up their medication from the pharmacy, and to perform a study to identify the causes and establish intervention strategies. This solution aligns with several articles published, such as one by Warren et al.26 This study looked at the effectiveness of follow up by primary care professionals guided by computerized medical history data to improve adherence medication. The results obtained were an improvement in adherence and good monitoring of patients that received the intervention, and that this is feasible, since it was well-received and well-accepted by the patients. Regarding the primary care expert group, the solution they proposed for this barrier was to create a protocol that integrates all the measures proposed at the meeting.

A study published in October 2019 by Carvalho et al27 reviewed literature on medication adherence in patients with high blood pressure and their relationship with the organizational factors of health standards. The authors concluded that non-adherence to medication treatment is a real problem today, and it depends on the interaction of factors related to the patient, providers, and the surrounding context. The role of the physician is not only to prescribe, but also to address all the aspects of the patient to comprehend the best strategy for each person individually. Promoting adherence is as important for the health of the population as the act of prescribing medication. This is explained by the fact that therapeutic adherence is a multi-faceted phenomenon that is determined by factors that go beyond the healthcare setting.3,5 Therefore, being aware of the factors that influence patient adherence to treatment is very important for overcoming therapeutic non-compliance.28,29

The study findings revealed that physicians from different settings have different opinion about the therapeutic adherence. The improvement plan that arose from the consensus between physicians from both settings might lead to the correct management of non-adherence in patients with chronic disease. The use of the nominal group technique as a consensus method allowed generating ideas related to problems and solutions of therapeutic adherence in chronic patients. However, as this method requires face-to-face meetings, some expert participants could have felt uncomfortable to contribute their views or discuss the opinion of another participant. This limitation was addressed through the facilitator who made easy the process by creating a comfortable environment. In addition, the study findings are only based on the perspective of physicians. A future study using the Delphi method and including different healthcare providers and patients will be conducted to develop strategic actions to improve therapeutic adherence in patients with chronic disease.

In conclusion, the polymedication and a poorly communicated interview with the patient were identified as possible causes of poor treatment adherence by both groups. PCP and HBP prioritized different causes and solutions of adherence. However, they achieved to develop an improvement plan to facilitate the control of therapeutic adherence in patients with chronic disease.