Chihiro Aoshima1, Shinichiro Fujimoto2, Ayako Kudo1, Yuko O Kawaguchi1, Kazuhisa Takamura1, Yuya Matsue1, Takao Kato1, Yoshifumi Kawamura3, Satoshi Kimura3, Yuki Kamo1, Yui O Nozaki1, Daigo Takahashi1, Nobuo Tomizawa4, Makoto Hiki1, Takatoshi Kasai1, Shuko Nojiri5, Hideyuki Miyauchi6, Ken-Ichi Hirano7, Kazunori Shimada1, Koji Murakami4, Tohru Minamino1,8. 1. Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan. 2. Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan. s-fujimo@tj8.so-net.ne.jp. 3. Department of Radiological Technology, Juntendo University Hospital, Tokyo, Japan. 4. Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. 5. Juntendo University Medical Technology Innovation Center, Tokyo, Japan. 6. Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. 7. Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics and Triglyceride Research Center (TGRC), Department of Triglyceride Science, Graduate School of Medicine, Osaka University, Osaka, Japan. 8. Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo, Japan.
Abstract
BACKGROUND: Recently, triglyceride deposit cardiomyovasculopathy (TGCV) with defective intracellular lipolysis was found to be a disease that causes heart failure. As a diagnostic criterion for TGCV, an Iodaine-123-β-methyl iodophenyl-pentadecanoic acid washout rate (BMIPP WOR) of < 10% is used, but its clinical significance in patients with heart failure remains to be clarified. METHODS: In 62 hospitalized patients with chronic heart failure, 123I-BMIPP myocardial single-photon emission computed tomography (SPECT) was performed predischarge state. The prevalence of TGCV was investigated. Subsequently, follow-up was conducted for ≥ 90 days (mean: 724.6 ± 392.7 days), and the association between the BMIPP WOR and cardiac events was examined, establishing all-cause mortality and admission due to heart failure as endpoints. RESULTS: Of the 62 patients, the WOR was < 10% in 41 (66.1%). Of these, 26 (41.9%) were diagnosed with definite TGCV. Furthermore, cardiac events were noted in 12 patients (19.4%). Analysis with Cox proportional hazards models showed that the BMIPP WOR < 4.5% was a significant event-predicting factor [HR 4.29, 95% CI: 1.20-16.87; p = 0.0245]. On a Kaplan-Meier curve, the WOR was 4.5%; there was a significant difference in the incidence of events (p = 0.0298). CONCLUSION: In the predischarge state of heart failure, 123I-BMIPP myocardial SPECT was performed. In approximately 40% of the patients, a diagnosis of TGCV was made. The results suggested that the BMIPP WOR is useful for predicting the prognosis of chronic heart failure patients regardless of TGCV.
BACKGROUND: Recently, triglyceride deposit cardiomyovasculopathy (TGCV) with defective intracellular lipolysis was found to be a disease that causes heart failure. As a diagnostic criterion for TGCV, an Iodaine-123-β-methyl iodophenyl-pentadecanoic acid washout rate (BMIPP WOR) of < 10% is used, but its clinical significance in patients with heart failure remains to be clarified. METHODS: In 62 hospitalized patients with chronic heart failure, 123I-BMIPP myocardial single-photon emission computed tomography (SPECT) was performed predischarge state. The prevalence of TGCV was investigated. Subsequently, follow-up was conducted for ≥ 90 days (mean: 724.6 ± 392.7 days), and the association between the BMIPP WOR and cardiac events was examined, establishing all-cause mortality and admission due to heart failure as endpoints. RESULTS: Of the 62 patients, the WOR was < 10% in 41 (66.1%). Of these, 26 (41.9%) were diagnosed with definite TGCV. Furthermore, cardiac events were noted in 12 patients (19.4%). Analysis with Cox proportional hazards models showed that the BMIPP WOR < 4.5% was a significant event-predicting factor [HR 4.29, 95% CI: 1.20-16.87; p = 0.0245]. On a Kaplan-Meier curve, the WOR was 4.5%; there was a significant difference in the incidence of events (p = 0.0298). CONCLUSION: In the predischarge state of heart failure, 123I-BMIPP myocardial SPECT was performed. In approximately 40% of the patients, a diagnosis of TGCV was made. The results suggested that the BMIPP WOR is useful for predicting the prognosis of chronic heart failure patients regardless of TGCV.
Authors: Y Fujibayashi; R Nohara; R Hosokawa; K Okuda; Y Yonekura; N Tamaki; J Konishi; S Sasayama; A Yokoyama Journal: J Nucl Med Date: 1996-05 Impact factor: 10.057
Authors: K Kataoka; R Nohara; R Hosokawa; T Hirai; K Okuda; C Li-Guang; Y Fujibayashi; M Fujita; J Konishi; S Sasayama Journal: J Nucl Med Date: 2001-01 Impact factor: 10.057
Authors: S Yamauchi; Y Takeishi; O Minamihaba; T Arimoto; O Hirono; H Takahashi; T Miyamoto; J Nitobe; N Nozaki; H Tachibana; T Watanabe; A Fukui; I Kubota Journal: Nucl Med Commun Date: 2003-08 Impact factor: 1.690