| Literature DB >> 35291948 |
Karla Seaman1, Kristiana Ludlow2, Nasir Wabe2, Laura Dodds2, Joyce Siette2,3, Amy Nguyen2,4, Mikaela Jorgensen2, Stephen R Lord5,6, Jacqueline C T Close5, Libby O'Toole7, Caroline Lin2, Annaliese Eymael2, Johanna Westbrook2.
Abstract
BACKGROUND: Falls in older adults remain a pressing health concern. With advancements in data analytics and increasing uptake of electronic health records, developing comprehensive predictive models for fall risk is now possible. We aimed to systematically identify studies involving the development and implementation of predictive falls models which used routinely collected electronic health record data in home-based, community and residential aged care settings.Entities:
Keywords: Aged care; Fall risk; Falls; Health & safety; Health informatics; Information technology; Older adults; Predictive modelling; Quality in health care; Risk management
Mesh:
Year: 2022 PMID: 35291948 PMCID: PMC8923829 DOI: 10.1186/s12877-022-02901-2
Source DB: PubMed Journal: BMC Geriatr ISSN: 1471-2318 Impact factor: 3.921
Fig. 1Study selection process (PRISMA), adapted from Page et al. (2021) [23]
Study characteristics
| Authors; Year; Country | Setting | Population aged group | Data Source | Study Design | Statistical Model | Derivation Cohort | Internal Validation Cohort (% of total cohort) | Falls Outcome Prediction | Falls Rate (%) | Risk Score/ Category | Number of models | Discrimination (AUC), (95% CI) | Implemented in practice |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Volrathongchai, et al.; 2005; US [ | Residential Care | 65–100 years | MDS | Retrospective | LBP | 9,980 (100%) | NR | Fall within 3-months | NR | No | 1 | NR | No |
| Marier, et.al.; 2016; US [ | Residential Care | NR | EMR and MDS | Retrospective | Repeated events survival model | 2,527 (49.3%) | 2,602 (50.7%) | NR | 2.3–32.3% across the deciles in validation cohort depending on the model used | Yes | 4 1:MDS Assessments 2: MDS Assessments & EMR only 3: MDS assessments & EMR duplicates 4: MDS assessments & EMR Only & EMR Duplicates | AIC 1: 6733 2: 6749 3: 6614 4:6626 | No |
| Kuspinar, et al.; 2019; Canada [ | Home care | 77 ± 14 years with no previous fall in the last 90 days | RAI-HC | Prospective | Decision tree | 88,690 (70%) | Internal: 38,013 (30%) External: 2,738 1,226 9,566 | NR | 5–35% across risk categories in derivative cohort | Yes | 1 | NR | No |
| Lo, et al.; 2019; US [ | Home care | 65 + years | OASIS and EHR | Retrospective | Random Forest Algorithm | 29,514 (50%) | 29,514 (50%) | NR | 5.14% (for emergency care or hospitalisation) | No | 3 – Validated against the MAHC-10 1: Combined 2: OASIS 3: MACH model | 1: 0.67 2: 0.67 (0.66, 0.68) 3: 0.6 (0.59,0.62) | No |
MDS Minimum Data Set, LBP Likelihood Basis Pursuit, EMR Electronic Medical record, RAI-HC Resident Assessment Instrument-Home Care, OASIS Outcome and Assessment information Set, AUC Area under the curve, AIC Akaike Information Criteria, MACH-10 Missouri Alliance for Home Care fall risk assessment, NR Not reported
Critical Appraisal Skills Program checklist
| Section a | Study | Volrathongchai et al. (2005) [ | Marier et al. (2016) [ | Kuspinar et al. (2019) [ | Lo et al. (2019) [ |
|---|---|---|---|---|---|
| A | 1. Is the Clinical Prediction Rule clearly defined? | Yes | Yes | Yes | Yes |
| A | 2. Is the population from which the rule was derived included an appropriate spectrum of patients? | Yes | Yes | Yes | Yes |
| A | 3. Was the rule validated in a different group of patients? | No | No | Yes | No |
| A | 4. Were the predictor variables and the outcome evaluated in a blinded fashion? | No | No | No | No |
| A | 5. Were the predictor variables and the outcome evaluated in the whole sample selected initially? | No | Yes | Yes | No |
| A | 6. Are the statistical methods used to construct and validate the rule clearly described? | Yes | Yes | Yes | Yes |
| B | 7. Can the performance of the rule be calculated? | No | No | No | Yes |
| B | 8. How precise was the estimate of the treatment effect? | No | Yes | No | Yes |
| C | 9. Would the prediction rule be reliable and the results interpretable if used for your patient? | No | Yes | Yes | Yes |
| C | 10. Is the rule acceptable in your case? | No | Yes | Yes | Can’t tell |
| C | 11. Would the results of the rule modify your decision about the management of the patient or the information you can give to him/her? | No | Yes | Yes | Can’t tell |
| Overall Score | Percentage of ‘yes’ responses | 27.3% | 72.7% | 72.7% | 54.5% |
a Section A focuses on validity of study results and whether it is worth continuing; Section B focuses on the study results; Section C identifies the applicability of the results and findings
Characteristics of predictors used in the final models of included studies
| Volrathongchai et al. (2005) [ | Marier et al. (2016) [ | Kuspinar et al. (2019) [ | Lo et al. (2019) [ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 1: MDS AssessmentsA | 2: MDS Assessments & EMR onlyA | 3: MDS assessments & EMR duplicatesA | 4: MDS assessments & EMR Only & EMR DuplicatesA | 1: Combined (OASIS & MACH) | 2: Oasis Model | 3: MACH Model | |||
| Age | |||||||||
| Sex | |||||||||
| Cognitive Performance Scale | |||||||||
| Activities of Daily Living Hierarchy | |||||||||
| Worsening of Activities of Daily Living Status | |||||||||
| Pain Scale | |||||||||
| Managing Medication | |||||||||
| Missouri Alliance for Home Care Fall Risk Assessment (MACH) | |||||||||
| Outcome and Assessment Information Set (OASIS-C) – 46 Itemsc | |||||||||
| Unstable Health Patterns | |||||||||
| Fall in Last 30 Days | |||||||||
| Fall in 31–180 Days | |||||||||
| Anticoagulant | |||||||||
| Anticonvulsant | |||||||||
| Antihypertensive (Alpha II Agonist) | |||||||||
| Antihypertensive (Alpha-Adregen Blocker) | |||||||||
| Antipsychotic (last 7 days) | |||||||||
| Antipsychotic | |||||||||
| Anxiolytic | |||||||||
| Antidepressant | |||||||||
| Diuretic | |||||||||
| Hypnotic | |||||||||
| Opioid Analgesic | |||||||||
| Psychotropic | |||||||||
| Anaemia | |||||||||
| Alzheimer's Disease | |||||||||
| Atrial Fibrillation | |||||||||
| Behavioural Problems | |||||||||
| Cognitive Impairment | |||||||||
| Depression | |||||||||
| Diagnosis Causing Imbalance | |||||||||
| Hearing loss | |||||||||
| Hemiplegia or Hemiparesis | |||||||||
| Incontinence | |||||||||
| Mental Instability | |||||||||
| Malnutrition | |||||||||
| Osteoporosis | |||||||||
| Pain | |||||||||
| Parkinson’s Disease | |||||||||
| Vision poor | |||||||||
| Urinary Tract Infection | |||||||||
| Ambulation | |||||||||
| Imbalance | |||||||||
| Mode of Expression: Writing | |||||||||
| Mobility in Bed | |||||||||
| Primary Mode of Locomotion | |||||||||
| Restricted Lower Range of Motion | |||||||||
| Use of Walking Aids | |||||||||
| Unsteady Gait | |||||||||
| Wandering | |||||||||
| Wheelchair Use | |||||||||
| Admission from Transfer | |||||||||
| Week after Admission | |||||||||
| Week after Room Change | |||||||||
| Total Number of Variables | |||||||||
MDS Minimum Data Set, EMR Electronic Medical record, OASIS Outcome and Assessment information Set, MACH-10 Missouri Alliance for Home Care fall risk assessment
a Models also contained the covariates: days since admission, days since admission squared, interactions between each risk factor and days since admission and duration of time that each resident exhibits a particular risk profile
b MACH scale includes the following ten binary variables: Age 65 + , Diagnosis (three or more co-existing), Prior history of falls within 3 months, Incontinence, Visual impairment, Impaired functional mobility, Environmental hazards, Polypharmacy (four or more prescriptions – any type), Pain affecting level of function, and Cognitive impairment
c OASIS contained 46 items of the 115, chosen based on literature and association with falls. These were used this to create 300 estimates. Example items included 2 + hospitalisations in the past year, shortness of breath, ability to hear and 2 + falls with an injury in the past year