Khalid Farouq Al-Rawi1, Hameed Hussein Ali1, Manaf Abdulrahman Guma2, Bilal Jasir Mohammed Aldahham2, Shakir Faris Tuleab Alaaraji3, Osamah Al-Ani4, Aus Tariq Ali5. 1. Department of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq. 2. Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq. 3. Department of Chemistry, College of Education for pure Science, University of Anbar, Al-anbar Province, Iraq. 4. Yarmouk Academic Hospital, Baghdad, Iraq. 5. University of Anbar, Al-anbar Province, Iraq.
Abstract
Background: Chronic kidney disease (CKD), is a major public health challenge worldwide. It is more prevalent in developed countries compared with the rest of the world, due to the higher rates of life expectancy and unhealthy lifestyle related factors. This aim of the current study is to evaluate the relationship between interleukins IL-2 and IL-17 concentrations and kidney function markers in men with CKD. Methods: Forty-five men with CKD and seventy controls were enrolled in the current study to assess the relationship between interleukin-2 (IL-2), interleukin-17 (IL-17), and CKD parameters. Fasting blood samples were collected from patients with CKD and their controls at same time. Serum IL-2, and IL-17 were measured in patients with CKD and their controls, and then the relationship between these interleukins and serum creatinine, serum urea, serum uric acid and urine albumin were evaluated. Results: A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations. The significant increase of IL-2 and IL-17 levels were also paralleled with a significant increase in serum urea (p< 0.001), and urine albumin (p< 0.001) concentrations respectively. Conclusion: IL-2 and IL-17 may play a critical role in the pathophysiology of CKD. The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy. However, due to limited sample size of the current study, larger prospective cohorts are needed to confirm these observations.
Background: Chronic kidney disease (CKD), is a major public health challenge worldwide. It is more prevalent in developed countries compared with the rest of the world, due to the higher rates of life expectancy and unhealthy lifestyle related factors. This aim of the current study is to evaluate the relationship between interleukins IL-2 and IL-17 concentrations and kidney function markers in men with CKD. Methods: Forty-five men with CKD and seventy controls were enrolled in the current study to assess the relationship between interleukin-2 (IL-2), interleukin-17 (IL-17), and CKD parameters. Fasting blood samples were collected from patients with CKD and their controls at same time. Serum IL-2, and IL-17 were measured in patients with CKD and their controls, and then the relationship between these interleukins and serum creatinine, serum urea, serum uric acid and urine albumin were evaluated. Results: A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations. The significant increase of IL-2 and IL-17 levels were also paralleled with a significant increase in serum urea (p< 0.001), and urine albumin (p< 0.001) concentrations respectively. Conclusion: IL-2 and IL-17 may play a critical role in the pathophysiology of CKD. The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy. However, due to limited sample size of the current study, larger prospective cohorts are needed to confirm these observations.
Authors: Ana C Ricardo; Cheryl A Anderson; Wei Yang; Xiaoming Zhang; Michael J Fischer; Laura M Dember; Jeffrey C Fink; Anne Frydrych; Nancy G Jensvold; Eva Lustigova; Lisa C Nessel; Anna C Porter; Mahboob Rahman; Julie A Wright Nunes; Martha L Daviglus; James P Lash Journal: Am J Kidney Dis Date: 2014-11-20 Impact factor: 8.860
Authors: Peter Stenvinkel; Markus Ketteler; Richard J Johnson; Bengt Lindholm; Roberto Pecoits-Filho; Miguel Riella; Olof Heimbürger; Tommy Cederholm; Matthias Girndt Journal: Kidney Int Date: 2005-04 Impact factor: 10.612
Authors: Ulla Derhaschnig; Harald Kittler; Christian Woisetschläger; Andreas Bur; Harald Herkner; Michael M Hirschl Journal: Nephrol Dial Transplant Date: 2002-01 Impact factor: 5.992
Authors: Mohammad H Forouzanfar; Lily Alexander; H Ross Anderson; Victoria F Bachman; Stan Biryukov; Michael Brauer; Richard Burnett; Daniel Casey; Matthew M Coates; Aaron Cohen; Kristen Delwiche; Kara Estep; Joseph J Frostad; K C Astha; Hmwe H Kyu; Maziar Moradi-Lakeh; Marie Ng; Erica Leigh Slepak; Bernadette A Thomas; Joseph Wagner; Gunn Marit Aasvang; Cristiana Abbafati; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Semaw F Abera; Victor Aboyans; Biju Abraham; Jerry Puthenpurakal Abraham; Ibrahim Abubakar; Niveen M E Abu-Rmeileh; Tania C Aburto; Tom Achoki; Ademola Adelekan; Koranteng Adofo; Arsène K Adou; José C Adsuar; Ashkan Afshin; Emilie E Agardh; Mazin J Al Khabouri; Faris H Al Lami; Sayed Saidul Alam; Deena Alasfoor; Mohammed I Albittar; Miguel A Alegretti; Alicia V Aleman; Zewdie A Alemu; Rafael Alfonso-Cristancho; Samia Alhabib; Raghib Ali; Mohammed K Ali; François Alla; Peter Allebeck; Peter J Allen; Ubai Alsharif; Elena Alvarez; Nelson Alvis-Guzman; Adansi A Amankwaa; Azmeraw T Amare; 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Jefferson Traebert; Bach X Tran; Leonardo Trasande; Matias Trillini; Ulises Trujillo; Zacharie Tsala Dimbuene; Miltiadis Tsilimbaris; Emin Murat Tuzcu; Uche S Uchendu; Kingsley N Ukwaja; Selen B Uzun; Steven van de Vijver; Rita Van Dingenen; Coen H van Gool; Jim van Os; Yuri Y Varakin; Tommi J Vasankari; Ana Maria N Vasconcelos; Monica S Vavilala; Lennert J Veerman; Gustavo Velasquez-Melendez; N Venketasubramanian; Lakshmi Vijayakumar; Salvador Villalpando; Francesco S Violante; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Gregory R Wagner; Stephen G Waller; Mitchell T Wallin; Xia Wan; Haidong Wang; JianLi Wang; Linhong Wang; Wenzhi Wang; Yanping Wang; Tati S Warouw; Charlotte H Watts; Scott Weichenthal; Elisabete Weiderpass; Robert G Weintraub; Andrea Werdecker; K Ryan Wessells; Ronny Westerman; Harvey A Whiteford; James D Wilkinson; Hywel C Williams; Thomas N Williams; Solomon M Woldeyohannes; Charles D A Wolfe; John Q Wong; Anthony D Woolf; Jonathan L Wright; Brittany Wurtz; Gelin Xu; 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