Hameed Hussein Ali1, Khalid Al-Rawi1, Yousif Khalaf2, Shakir Alaaraji3, Bilal Aldahham4, Muthanna Awad3, Osamah Al-Ani5, Faisal Al-Ani5, Aus Tariq Ali6. 1. Departemnt of Chemistry, College of Sciences, University of Anbar, Ramadi, Al-Anbar province Iraq. 2. Department of Clinical Laboratory Sciences, College of Pharmacy, University of Anbar, Ramadi, Al-Anbar province, Iraq. 3. Department of Chemistry, College of Education for Pure Sciences, University of Anbar, Ramadi, Al-Anbar province, Iraq. 4. Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Ramadi, Al-Anbar province, Iraq. 5. Odessa National Medical University, Odessa, 65000, Ukraine. 6. University of Al-Rasheed College, Baghdad, Iraq.
Abstract
Background: The fluctuation in serum caveolin-1 (Cav-1) concentrations is an important indicator of many diseases. Irrespective of the actual cause, a significant reduction of serum Cav-1 is associated with a significant increase in insulin secretion and hyperinsulinemia. The aim of the current study was to evaluate the relationship between serum Cav-1, serum vaspin and visfatin in newly diagnosed men with T2DM. Methods: Eighty-two newly diagnosed men with T2DM were matched for age and body mass indexes (BMIs) with a similar number of non-diabetic men. Serum Cav-1, vaspin and visfatin were assessed through enzyme-linked immunosorbent assay. Fasting serum glucose (FSG), glycohaemoglobin A1C (HbA1c) were both measured using automated method. In addition, waist-circumferences, waist-hip ratio, systolic (SBP), and diastolic blood pressure (DBP) were also obtained. Results: Serum concentration of Cav-1(ng/mL) was significantly low in men newly diagnosed with T2DM, (2.334±0.7627) compared with non-diabetic controls (4.321±1.143), p< 0.0001. In contrast, patients with T2DM exhibited significantly higher serum concentrations of vaspin and visfatin (ng/mL), 142.4±60.53) and 2.99±1.091), than controls, 81.53±39.32) and 1.456±0.654), respectively, p< 0.0001. Expectedly, patients with T2DM have significantly higher FSG, HbA1c, systolic blood pressure (SBP), and diastolic blood pressure (DBP). Conclusion: There was an inverse significant relationship between Cav-1 and vaspin, visfatin, HbA1c, FSG, and hypertension. This study suggests that serum Cav-1 can be used as a diagnostic marker to predict T2DM in individuals and families under high risk.
Background: The fluctuation in serum caveolin-1 (Cav-1) concentrations is an important indicator of many diseases. Irrespective of the actual cause, a significant reduction of serum Cav-1 is associated with a significant increase in insulin secretion and hyperinsulinemia. The aim of the current study was to evaluate the relationship between serum Cav-1, serum vaspin and visfatin in newly diagnosed men with T2DM. Methods: Eighty-two newly diagnosed men with T2DM were matched for age and body mass indexes (BMIs) with a similar number of non-diabetic men. Serum Cav-1, vaspin and visfatin were assessed through enzyme-linked immunosorbent assay. Fasting serum glucose (FSG), glycohaemoglobin A1C (HbA1c) were both measured using automated method. In addition, waist-circumferences, waist-hip ratio, systolic (SBP), and diastolic blood pressure (DBP) were also obtained. Results: Serum concentration of Cav-1(ng/mL) was significantly low in men newly diagnosed with T2DM, (2.334±0.7627) compared with non-diabetic controls (4.321±1.143), p< 0.0001. In contrast, patients with T2DM exhibited significantly higher serum concentrations of vaspin and visfatin (ng/mL), 142.4±60.53) and 2.99±1.091), than controls, 81.53±39.32) and 1.456±0.654), respectively, p< 0.0001. Expectedly, patients with T2DM have significantly higher FSG, HbA1c, systolic blood pressure (SBP), and diastolic blood pressure (DBP). Conclusion: There was an inverse significant relationship between Cav-1 and vaspin, visfatin, HbA1c, FSG, and hypertension. This study suggests that serum Cav-1 can be used as a diagnostic marker to predict T2DM in individuals and families under high risk.
Authors: Manuel A Fernández-Rojo; Milena Gongora; Rebecca L Fitzsimmons; Nick Martel; Sheree D Martin; Susan J Nixon; Andrew J Brooks; Maria P Ikonomopoulou; Sally Martin; Harriet P Lo; Stephen A Myers; Christina Restall; Charles Ferguson; Paul F Pilch; Sean L McGee; Robin L Anderson; Michael J Waters; John F Hancock; Sean M Grimmond; George E O Muscat; Robert G Parton Journal: Cell Rep Date: 2013-07-11 Impact factor: 9.423
Authors: Mei Han; Zeribe Chike Nwosu; Weronika Piorońska; Matthias Philip Ebert; Steven Dooley; Christoph Meyer Journal: Front Physiol Date: 2020-01-31 Impact factor: 4.566