| Literature DB >> 35291445 |
Wenli Liu1, Griffin P Rodgers1.
Abstract
Biomarkers of infectious diseases are essential tools for patient monitoring, diagnostics, and prognostics. Here we review recent advances in our understanding of olfactomedin 4 (OLFM4) in neutrophil biology and of OLFM4 as a new biomarker for certain infectious diseases. OLFM4 is a neutrophil-specific granule protein that is expressed in a subset of human and mouse neutrophils. OLFM4 expression is upregulated in many viral and bacterial infections, as well as in malaria. OLFM4 appears to play an important role in regulating host innate immunity against bacterial infection. Further, higher expression of OLFM4 is associated with severity of disease for dengue virus, respiratory syncytial virus, and malaria infections. In addition, higher expression of OLFM4 or a higher percentage of OLFM4 + neutrophils is associated with poorer outcomes in septic patients. OLFM4 is a promising biomarker and potential therapeutic target in certain infectious diseases. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.Entities:
Keywords: bacteria; infectious disease; olfactomedin 4; sepsis; virus
Year: 2022 PMID： 35291445 PMCID： PMC8918383 DOI： 10.1093/ofid/ofac061
Source DB: PubMed Journal: Open Forum Infect Dis ISSN： 2328-8957 Impact factor: 3.835