Background: The giant cell tumour of the bone has a spectrum of clinical-radiological presentation. This study aims to describe this varied presentation in our institution. Methods: This retrospective study was conducted on twenty-nine pathologically labelled cases of giant cell tumours of the bone. The medical records for their clinical presentation and diagnostic imaging studies were studied and evaluated. Results: Mean age of the patients at presentation was 35.3±12.9 years. Pain, local swelling and restricted joint function were seen in 93 %, 58.6 % and 52 % patients, respectively. The cortical breach was seen in 15 (51.7 %) and 22 (75.9 %) lesions on plain radiographs and CT images, respectively. 14(48.3 %) cases had soft tissue invasion on MRI at presentation. 26 (89.7 %) lesions were located within 1 cm from the articular cartilage. The solid tumour component was hypo to iso-intense in signal intensity in 27 (93.1 %) lesions in T1 weighted and 21 (72.4 %) in T2 weighted images. 14 (48.3 %) had hyperintense cystic areas, and fluid-fluid levels, suggestive of aneurysmal bone cysts, were seen in 4 (13.8 %) cases on T2 weighted images. Hypo-echoic nodular areas in solid tumour component, suggestive of hemosiderin deposits, were present in 3 (10.3 %) lesions on T1 and T2 weighted images. Conclusion: The tumour classically presents as an epiphysial-metaphyseal, eccentric, expansile, lytic lesion in a skeletally mature patient. The MRI picture is variable and the surgeon should have a sound knowledge of these variations to obtain a biopsy sample from a proper site of the lesion and to avoid misdiagnosis especially of a primary ABC.
Background: The giant cell tumour of the bone has a spectrum of clinical-radiological presentation. This study aims to describe this varied presentation in our institution. Methods: This retrospective study was conducted on twenty-nine pathologically labelled cases of giant cell tumours of the bone. The medical records for their clinical presentation and diagnostic imaging studies were studied and evaluated. Results: Mean age of the patients at presentation was 35.3±12.9 years. Pain, local swelling and restricted joint function were seen in 93 %, 58.6 % and 52 % patients, respectively. The cortical breach was seen in 15 (51.7 %) and 22 (75.9 %) lesions on plain radiographs and CT images, respectively. 14(48.3 %) cases had soft tissue invasion on MRI at presentation. 26 (89.7 %) lesions were located within 1 cm from the articular cartilage. The solid tumour component was hypo to iso-intense in signal intensity in 27 (93.1 %) lesions in T1 weighted and 21 (72.4 %) in T2 weighted images. 14 (48.3 %) had hyperintense cystic areas, and fluid-fluid levels, suggestive of aneurysmal bone cysts, were seen in 4 (13.8 %) cases on T2 weighted images. Hypo-echoic nodular areas in solid tumour component, suggestive of hemosiderin deposits, were present in 3 (10.3 %) lesions on T1 and T2 weighted images. Conclusion: The tumour classically presents as an epiphysial-metaphyseal, eccentric, expansile, lytic lesion in a skeletally mature patient. The MRI picture is variable and the surgeon should have a sound knowledge of these variations to obtain a biopsy sample from a proper site of the lesion and to avoid misdiagnosis especially of a primary ABC.
Authors: Jonathan Lans; Kamil Oflazoglu; Hang Lee; Neil G Harness; René M Castelein; Neal C Chen; Santiago A Lozano Calderón Journal: J Hand Surg Am Date: 2020-06-29 Impact factor: 2.230
Authors: Jong Won Kwon; Hye Won Chung; Eun Yoon Cho; Sung Hwan Hong; Sang-Hee Choi; Young Cheol Yoon; Sang Kyu Yi Journal: AJR Am J Roentgenol Date: 2007-07 Impact factor: 3.959
Authors: J Aoki; K Moriya; K Yamashita; F Fujioka; K Ishii; O Karakida; S Imai; F Sakai; Y Imai; S Sone Journal: J Comput Assist Tomogr Date: 1991 Nov-Dec Impact factor: 1.826
Authors: R G Forsyth; G De Boeck; S Bekaert; T De Meyer; A H M Taminiau; D Uyttendaele; H Roels; M M Praet; P C W Hogendoorn Journal: J Pathol Date: 2008-04 Impact factor: 7.996
Authors: Kevin A Raskin; Joseph H Schwab; Henry J Mankin; Dempsey S Springfield; Francis J Hornicek Journal: J Am Acad Orthop Surg Date: 2013-02 Impact factor: 3.020
Authors: Lizz van der Heijden; P D Sander Dijkstra; Domenico A Campanacci; C L Max H Gibbons; Michiel A J van de Sande Journal: Clin Orthop Relat Res Date: 2013-03 Impact factor: 4.176