| Literature DB >> 35286443 |
Rajan Gyawali1, Ashok Baral1, Dikshya Upreti1, Chandra Bhushan Yadav2, Anoop Krishna Gupta3, Miyuru Chandradasa4, Sheikh Shoib5.
Abstract
Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia and treated with olanzapine throughout the pregnancy delivering a baby boy with congenital talipes equinovarus deformity. Like in many other low-income settings, pregnancy was unplanned, and pre-conception counselling was not done. Research in mice has revealed the negative effects of olanzapine on bone development. Further reports would strengthen this potential association between exposure to olanzapine in the first trimester and the occurrence of clubfoot in the baby.Entities:
Keywords: Antipsychotic agents; Clubfoot; Congenital abnormalities; Olanzapine; Talipes varus
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Year: 2022 PMID： 35286443 DOI： 10.1007/s00737-022-01221-z
Source DB: PubMed Journal: Arch Womens Ment Health ISSN： 1434-1816 Impact factor: 3.633