| Literature DB >> 35270329 |
Emilian Zadarko1, Maria Zadarko-Domaradzka1, Zbigniew Barabasz1, Marek Sobolewski2.
Abstract
The health condition of working-age males in Poland remains largely associated with long-lasting sick leaves, one of the main reasons of which being cardiovascular diseases (CVD). The aim of this work was to develop a prediction model for FIT Treadmill Score ("FIT" refers to Henry Ford ExercIse Testing (FIT) Project) that only depends on easily accessible somatic data and smoking without the need to perform the exercise test anymore. The study comprised 146 men with a negative cardiological history, aged 26-60, with desk-jobs. By means of regression analysis it was tested to what degree obesity-related indices as well as smoking cigarettes allow for determining the measure level of mortality risk, without the necessity of performing an exercise test. The following independent variables were entered into the linear regression model: age, BMI, Fat%, waist circumference (WC), waist to height ratio (WHtR) as well as smoking. Statistically significant factors were singled out from among them. The obtained model accounts for a significant part (over 87%) of the variability of the mortality risk measure among the tested population. Based on the value of the standardised regression coefficient β, it can be stated that age is the factor that mostly determines the mortality risk measure, followed by the WHtR and smoking. The simplicity of the worked-out model and, resulting from it, the possibility of its common application should enable better health monitoring of working-age men with regard to cardiovascular disease occurrence and, related to it, mortality risk, thereby improving the quality of public health management.Entities:
Keywords: CRF; FIT Treadmill Score; cardiovascular diseases; disease prevention; risk prediction
Mesh:
Year: 2022 PMID: 35270329 PMCID: PMC8909649 DOI: 10.3390/ijerph19052643
Source DB: PubMed Journal: Int J Environ Res Public Health ISSN: 1660-4601 Impact factor: 3.390
Risk of mortality in 10 years—classification based on FIT Treadmill Score.
| FIT Treadmill Score | Risk of Mortality in 10 Years |
|---|---|
| ≥100 | 2% |
| [0; 100) | 3% |
| [−100; 0) | 11% |
| <−100 | 38% |
General characteristics of the study population.
| Age and Somatic | Mean (95% CI) | Std. Dev. | Minimum | Median | Maximum |
|---|---|---|---|---|---|
| Age (years) | 38.7 (37.1; 40.4) | 10.0 | 25 | 30 | 60 |
| BMI (kg/m2) | 26.4 (25.9; 26.9) | 3.3 | 16.9 | 26.1 | 34.7 |
| Fat (%) | 21.0 (20.2; 21.9) | 5.3 | 3.8 | 20.9 | 39.1 |
| WC (cm) | 95.2 (93.7; 96.6) | 8.7 | 70 | 96 | 117 |
| WHtR | 53.8 (53.0; 54.6) | 4.9 | 41.2 | 53.7 | 67.5 |
| Body height (cm) | 177.0 (176.1; 177.9) | 5.7 | 166 | 176 | 194 |
| MET | 10.7 (10.4; 11.0) | 2.0 | 6.7 | 10.8 | 16.2 |
| HR max (bpm) | 176.4 (173.9; 178.9) | 15.5 | 126 | 177 | 210 |
BMI—Body Mass Index; Fat—body mass fat; WC—Waist Circumference; WHtR—Waist to Height Ratio; MET—Metabolic Equivalent of Task; HRmax—maximal Heart Rate; 95% CI—95% confidence interval; Std. dev.—standard deviation.
Descriptive statistics for FIT Treadmill Score.
| Mean (95% CI) | Std. Dev. | Min | Median | Max | |
|---|---|---|---|---|---|
| FIT Treadmill Score | 69.4 (60.3; 78.6) | 56.1 | −59.1 | 82.6 | 190.3 |
Figure 1Distribution of FIT Treadmill Score and risk of mortality classification in 10 years.
Figure 2Distribution of FIT Treadmill Score and risk of mortality classification in 10 years.
Regression model for predicting FIT Treadmill Score.
| Independent Features | FIT Treadmill Score | ||
|---|---|---|---|
| B (95% CI) |
|
| |
| Age (years) | −4.58 (−4.92; −4.24) | ≤0.001 | −0.82 |
| Smoking cigarettes | −11.20 (−19.59; −2.81) | 0.009 | −0.08 |
| WHtR (0–100) | −2.64 (−3.33; −1.94) | ≤0.001 | −0.23 |
R2—coefficient of determination, F—test statistic and p value for significance of whole model, SSE—standard error of estimation, B—regression coefficient with 95% CI, ß—standardise regression coefficient, p value.
The logistic regression model for the occurrence of the 11% mortality risk according to the FIT Treadmill Score.
| Independent Features | Modelling Probability of 11% Mortality Risk | |
|---|---|---|
| OR (95% p.u.) |
| |
| Age (years) | 1.66 (1.26–2.17) | ≤0.001 |
| Smoking cigarettes | 93.47 (3.82–2287.76) | 0.005 |
| WHtR | 1.31 (1.02–1.69) | 0.035 |
Accuracy of the classification into the group with the 11% mortality risk based on the logistic regression model.
| Prognosis of the 11% Mortality Risk Based on the Model | Observed Condition (11% Mortality Risk) | |
|---|---|---|
| Yes | No | |
| Yes | 19 | 2 |
| No | 2 | 123 |
| Total | 21 (TPR = 90%) | 125 (TNR = 98%) |
TPR (sensitivity)—true positive rate, TNR (specificity)—true negative rate.
Figure 3Assessment of point measure of mortality risk and likelihood of being in group with 11% risk of mortality in Excel for four hypothetical men—spreadsheet screen. WHtR—Waist to Height Ratio.