Tian Xiao1, Sara Renata Alex Wijnant1,2,3, Isabelle van der Velpen1,4, Natalie Terzikhan1, Lies Lahousse1,3, M Kamran Ikram1,5, Meike W Vernooij1,4, Guy G Brusselle6,7,8, M Arfan Ikram9. 1. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. 2. Department of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. 3. Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. 4. Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. 5. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. 6. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. guy.brusselle@UGent.be. 7. Department of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. guy.brusselle@UGent.be. 8. Department of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. guy.brusselle@UGent.be. 9. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. m.a.ikram@erasmusmc.nl.
Abstract
OBJECTIVE: To investigate the association of chronic obstructive pulmonary disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) with cognitive performance and presence of vascular brain lesions (VBL). METHODS: We determined both cross-sectional and longitudinal association of lung function impairment with cognition, as well as cross-sectional association of lung function impairment with VBL, in the general population. Between 2009 and 2014 we included 3,941 participants from the Rotterdam Study with spirometry tests, brain MRI scans and cognition tests, of whom 1815 had follow-up data on cognition. RESULTS: Our finding indicated that cross-sectionally, participants with PRISm or COPD GOLD2-4 had a worse global cognitive performance. We did not find differences in cognition over time between those with normal spirometry versus those with lung function impairment. In addition, PRISm and COPD GOLD2-4 were associated with a higher prevalence of lacunar infarcts compared to normal spirometry. CONCLUSIONS: This study suggests that persons with COPD GOLD2-4 or restrictive lung function, defined as PRISm, are characterized by poorer global cognitive function and a higher prevalence of lacunar infarcts.
OBJECTIVE: To investigate the association of chronic obstructive pulmonary disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) with cognitive performance and presence of vascular brain lesions (VBL). METHODS: We determined both cross-sectional and longitudinal association of lung function impairment with cognition, as well as cross-sectional association of lung function impairment with VBL, in the general population. Between 2009 and 2014 we included 3,941 participants from the Rotterdam Study with spirometry tests, brain MRI scans and cognition tests, of whom 1815 had follow-up data on cognition. RESULTS: Our finding indicated that cross-sectionally, participants with PRISm or COPD GOLD2-4 had a worse global cognitive performance. We did not find differences in cognition over time between those with normal spirometry versus those with lung function impairment. In addition, PRISm and COPD GOLD2-4 were associated with a higher prevalence of lacunar infarcts compared to normal spirometry. CONCLUSIONS: This study suggests that persons with COPD GOLD2-4 or restrictive lung function, defined as PRISm, are characterized by poorer global cognitive function and a higher prevalence of lacunar infarcts.
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