Carol L Hodgson1,2,3, Alisa M Higgins1, Michael J Bailey1, Anne M Mather1, Lisa Beach4, Rinaldo Bellomo1,5,6, Bernie Bissett7,8, Ianthe J Boden9,10, Scott Bradley3, Aidan Burrell1,2, D James Cooper1,2, Bentley J Fulcher1, Kimberley J Haines5,11, Isabelle T Hodgson1, Jack Hopkins1, Alice Y M Jones12, Stuart Lane1,13, Drew Lawrence3, Lisa van der Lee14, Jennifer Liacos3, Natalie J Linke1, Lonni Marques Gomes1, Marc Nickels15, George Ntoumenopoulos16, Paul S Myles17, Shane Patman18, Michelle Paton1,19, Gemma Pound1,20, Sumeet Rai21,22, Alana Rix3, Thomas C Rollinson22,23, Claire J Tipping3, Peter Thomas24, Tony Trapani1, Andrew A Udy1,2, Christina Whitehead1,13, Shannah Anderson1, Ary Serpa Neto1,5,6,25. 1. Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine. 2. Department of Intensive Care and Hyperbaric Medicine and. 3. Department of Physiotherapy, the Alfred, Melbourne, Victoria, Australia. 4. Department of Physiotherapy (Allied Health), the Royal Melbourne Hospital, Melbourne, Victoria, Australia. 5. Department of Critical Care, School of Medicine, and. 6. Data Analytics Research and Evaluation (DARE) Centre, Austin Hospital, Melbourne, Victoria, Australia. 7. Discipline of Physiotherapy, University of Canberra, Canberra, Australian Capital Territory, Australia. 8. Physiotherapy Department, Canberra Hospital, Canberra, Australian Capital Territory, Australia. 9. Physiotherapy Department, Launceston General Hospital, Launceston, Tasmania, Australia. 10. School of Medicine, University of Tasmania, Tasmania, Australia. 11. Physiotherapy Department, Western Health, Melbourne, Victoria, Australia. 12. School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, Queensland, Australia. 13. Intensive Care Medicine, Nepean Hospital, Kingswood, New South Wales, Australia. 14. Fiona Stanley Hospital, Perth, Western Australia, Australia. 15. Physiotherapy Department, Princess Alexandra Hospital, Metro South Health, Queensland, Australia. 16. Physiotherapy, St. Vincent's Hospital, Sydney, New South Wales, Australia. 17. Department of Anaesthesiology and Perioperative Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia. 18. Faculty of Medicine, Nursing and Midwifery, Health Sciences, and Physiotherapy, the University of Notre Dame Australia, Perth, Western Australia, Australia. 19. Department of Physiotherapy, Monash Health, Melbourne, Victoria, Australia. 20. Physiotherapy Department, St. Vincent's Hospital, Melbourne, Victoria, Australia. 21. Canberra Health Services, Canberra, Australian Capital Territory, Australia. 22. Medical School, Australia National University, Canberra, Australian Capital Territory, Australia. 23. Department of Physiotherapy, Division of Allied Health, Austin Health, Melbourne, Victoria, Australia. 24. Department of Physiotherapy, The University of Melbourne, Victoria, Australia. 25. Department of Physiotherapy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; and.
Abstract
Rationale: The outcomes of survivors of critical illness due to coronavirus disease (COVID-19) compared with non-COVID-19 are yet to be established. Objectives: We aimed to investigate new disability at 6 months in mechanically ventilated patients admitted to Australian ICUs with COVID-19 compared with non-COVID-19. Methods: We included critically ill patients with COVID-19 and non-COVID-19 from two prospective observational studies. Patients were eligible if they were adult (age ⩾ 8 yr) and received ⩾24 hours of mechanical ventilation. In addition, patients with COVID-19 were eligible with a positive laboratory PCR test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Measurements and Main Results: Demographic, intervention, and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Between March 6, 2020, and April 21, 2021, 120 critically ill patients with COVID-19, and between August 2017 and January 2019, 199 critically ill patients without COVID-19, fulfilled the inclusion criteria. Patients with COVID-19 were older (median [interquartile range], 62 [55-71] vs. 58 [44-69] yr; P = 0.019) with a lower Acute Physiology and Chronic Health Evaluation II score (17 [13-20] vs. 19 [15-23]; P = 0.011). Although duration of ventilation was longer in patients with COVID-19 than in those without COVID-19 (12 [5-19] vs. 4.8 [2.3-8.8] d; P < 0.001), 180-day mortality was similar between the groups (39/120 [32.5%] vs. 70/199 [35.2%]; P = 0.715). The incidence of death or new disability at 180 days was similar (58/93 [62.4%] vs. 99/150 [66/0%]; P = 0.583). Conclusions: At 6 months, there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared with non-COVID-19. Clinical trial registered with www.clinicaltrials.gov (NCT04401254).
Rationale: The outcomes of survivors of critical illness due to coronavirus disease (COVID-19) compared with non-COVID-19 are yet to be established. Objectives: We aimed to investigate new disability at 6 months in mechanically ventilated patients admitted to Australian ICUs with COVID-19 compared with non-COVID-19. Methods: We included critically ill patients with COVID-19 and non-COVID-19 from two prospective observational studies. Patients were eligible if they were adult (age ⩾ 8 yr) and received ⩾24 hours of mechanical ventilation. In addition, patients with COVID-19 were eligible with a positive laboratory PCR test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Measurements and Main Results: Demographic, intervention, and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Between March 6, 2020, and April 21, 2021, 120 critically ill patients with COVID-19, and between August 2017 and January 2019, 199 critically ill patients without COVID-19, fulfilled the inclusion criteria. Patients with COVID-19 were older (median [interquartile range], 62 [55-71] vs. 58 [44-69] yr; P = 0.019) with a lower Acute Physiology and Chronic Health Evaluation II score (17 [13-20] vs. 19 [15-23]; P = 0.011). Although duration of ventilation was longer in patients with COVID-19 than in those without COVID-19 (12 [5-19] vs. 4.8 [2.3-8.8] d; P < 0.001), 180-day mortality was similar between the groups (39/120 [32.5%] vs. 70/199 [35.2%]; P = 0.715). The incidence of death or new disability at 180 days was similar (58/93 [62.4%] vs. 99/150 [66/0%]; P = 0.583). Conclusions: At 6 months, there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared with non-COVID-19. Clinical trial registered with www.clinicaltrials.gov (NCT04401254).
Entities:
Keywords:
SARS-CoV-2; critical care; long COVID; long-term outcomes; recovery
Authors: Jessica González; María Zuil; Iván D Benítez; David de Gonzalo-Calvo; María Aguilar; Sally Santisteve; Rafaela Vaca; Olga Minguez; Faty Seck; Gerard Torres; Jordi de Batlle; Silvia Gómez; Silvia Barril; Anna Moncusí-Moix; Aida Monge; Clara Gort-Paniello; Ricard Ferrer; Adrián Ceccato; Laia Fernández; Ana Motos; Jordi Riera; Rosario Menéndez; Darío Garcia-Gasulla; Oscar Peñuelas; Gonzalo Labarca; Jesús Caballero; Carme Barberà; Antoni Torres; Ferran Barbé Journal: Front Med (Lausanne) Date: 2022-07-14