Literature DB >> 35248489

Precision medicine in rheumatoid arthritis.

Kartik Bhamidipati1, Kevin Wei2.   

Abstract

Rheumatoid arthritis is an autoimmune disease that causes significant morbidity. Application of cellular profiling techniques such as single-cell transcriptomics and spatial transcriptomics has uncovered novel pathogenic cell types in RA joint tissues and revealed marked heterogeneity in the cellular composition among RA patients. Together, these insights provide exciting opportunities to translate discoveries into precision medicine in RA. The present review aims to highlight novel insights into RA pathology and discuss key steps needed to translate these discoveries into actionable changes in clinical practice. We review the efforts to identify surrogate biomarkers that could be used to predict RA synovial tissue phenotypes and the corresponding responses to therapy. Finally, we discuss the opportunity to develop novel patient-derived organoid systems as a platform for therapeutic target validation.
Copyright © 2022 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Organoids; Precision medicine; Rheumatoid arthritis; Single-cell RNAseq; Spatial transcriptomics

Mesh：

Substances：

Year:  2022        PMID： 35248489      PMCID： PMC8977251          DOI： 10.1016/j.berh.2022.101742

Source DB:  PubMed          Journal:  Best Pract Res Clin Rheumatol        ISSN： 1521-6942            Impact factor:   4.098


  92 in total

Review 1.  Biomarkers to guide clinical therapeutics in rheumatology?

Authors:  William H Robinson; Rong Mao
Journal:  Curr Opin Rheumatol       Date:  2016-03       Impact factor: 5.006

2.  Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.

Authors:  Stefano Alivernini; Lucy MacDonald; Aziza Elmesmari; Samuel Finlay; Barbara Tolusso; Maria Rita Gigante; Luca Petricca; Clara Di Mario; Laura Bui; Simone Perniola; Moustafa Attar; Marco Gessi; Anna Laura Fedele; Sabarinadh Chilaka; Domenico Somma; Stephen N Sansom; Andrew Filer; Charles McSharry; Neal L Millar; Kristina Kirschner; Alessandra Nerviani; Myles J Lewis; Costantino Pitzalis; Andrew R Clark; Gianfranco Ferraccioli; Irina Udalova; Christopher D Buckley; Elisa Gremese; Iain B McInnes; Thomas D Otto; Mariola Kurowska-Stolarska
Journal:  Nat Med       Date:  2020-06-29       Impact factor: 53.440

3.  Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.

Authors:  Patrik L Ståhl; Fredrik Salmén; Sanja Vickovic; Anna Lundmark; José Fernández Navarro; Jens Magnusson; Stefania Giacomello; Michaela Asp; Jakub O Westholm; Mikael Huss; Annelie Mollbrink; Sten Linnarsson; Simone Codeluppi; Åke Borg; Fredrik Pontén; Paul Igor Costea; Pelin Sahlén; Jan Mulder; Olaf Bergmann; Joakim Lundeberg; Jonas Frisén
Journal:  Science       Date:  2016-07-01       Impact factor: 47.728

4.  Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus.

Authors:  Jennifer H Anolik; Jennifer Barnard; Amedeo Cappione; Aimee E Pugh-Bernard; Raymond E Felgar; R John Looney; Iñaki Sanz
Journal:  Arthritis Rheum       Date:  2004-11

Review 5.  The central role of T cells in rheumatoid arthritis.

Authors:  A P Cope; H Schulze-Koops; M Aringer
Journal:  Clin Exp Rheumatol       Date:  2007 Sep-Oct       Impact factor: 4.473

6.  Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions.

Authors:  Asbjørn Christophersen; Eivind G Lund; Omri Snir; Elsa Solà; Chakravarthi Kanduri; Shiva Dahal-Koirala; Stephanie Zühlke; Øyvind Molberg; Paul J Utz; Mina Rohani-Pichavant; Julia F Simard; Cornelia L Dekker; Knut E A Lundin; Ludvig M Sollid; Mark M Davis
Journal:  Nat Med       Date:  2019-03-25       Impact factor: 53.440

7.  Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.

Authors:  Diana G Adlowitz; Jennifer Barnard; Jamie N Biear; Christopher Cistrone; Teresa Owen; Wensheng Wang; Arumugam Palanichamy; Ezinma Ezealah; Debbie Campbell; Chungwen Wei; R John Looney; Inaki Sanz; Jennifer H Anolik
Journal:  PLoS One       Date:  2015-06-05       Impact factor: 3.240

8.  Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.

Authors:  James Kinchen; Hannah H Chen; Kaushal Parikh; Agne Antanaviciute; Marta Jagielowicz; David Fawkner-Corbett; Neil Ashley; Laura Cubitt; Esther Mellado-Gomez; Moustafa Attar; Eshita Sharma; Quin Wills; Rory Bowden; Felix C Richter; David Ahern; Kamal D Puri; Jill Henault; Francois Gervais; Hashem Koohy; Alison Simmons
Journal:  Cell       Date:  2018-09-27       Impact factor: 41.582

9.  Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

Authors:  Glynn Dennis; Cécile T J Holweg; Sarah K Kummerfeld; David F Choy; A Francesca Setiadi; Jason A Hackney; Peter M Haverty; Houston Gilbert; Wei Yu Lin; Lauri Diehl; S Fischer; An Song; David Musselman; Micki Klearman; Cem Gabay; Arthur Kavanaugh; Judith Endres; David A Fox; Flavius Martin; Michael J Townsend
Journal:  Arthritis Res Ther       Date:  2014-04-30       Impact factor: 5.156

10.  Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

Authors:  Fumitaka Mizoguchi; Kamil Slowikowski; Kevin Wei; Jennifer L Marshall; Deepak A Rao; Sook Kyung Chang; Hung N Nguyen; Erika H Noss; Jason D Turner; Brandon E Earp; Philip E Blazar; John Wright; Barry P Simmons; Laura T Donlin; George D Kalliolias; Susan M Goodman; Vivian P Bykerk; Lionel B Ivashkiv; James A Lederer; Nir Hacohen; Peter A Nigrovic; Andrew Filer; Christopher D Buckley; Soumya Raychaudhuri; Michael B Brenner
Journal:  Nat Commun       Date:  2018-02-23       Impact factor: 14.919
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