| Literature DB >> 30911136 |
Asbjørn Christophersen1,2,3,4, Eivind G Lund1,2,3, Omri Snir1,2,3, Elsa Solà4,5, Chakravarthi Kanduri1,6, Shiva Dahal-Koirala1,2,3, Stephanie Zühlke1,2,3, Øyvind Molberg2,7, Paul J Utz4, Mina Rohani-Pichavant4, Julia F Simard8, Cornelia L Dekker9, Knut E A Lundin1,2,10, Ludvig M Sollid11,12,13,14, Mark M Davis15,16,17.
Abstract
Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.Entities:
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Year: 2019 PMID： 30911136 PMCID： PMC6647859 DOI： 10.1038/s41591-019-0403-9
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440