Literature DB >> 3524753

Corticotropin-releasing factor (CRF) inhibits gonadotropin-releasing hormone (GnRH) release from superfused rat hypothalami in vitro.

K E Nikolarakis, O F Almeida, A Herz.   

Abstract

A dose-dependent suppression of basal gonadotropin-releasing hormone (GnRH) release was observed when rat hypothalamic slices were superfused with human/rat corticotropin-releasing factor (CRF) (10(-12) to 10(-8) M). CRF was also found to significantly reduce the amount of GnRH released in response to 56 mM KCl. These in vitro results demonstrate that the CRF inhibition of GnRH secretion observed in vivo occurs within the hypothalamus and independently of the CRF activation of the pituitary-adrenal-gonadal axis.

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Year:  1986        PMID： 3524753     DOI： 10.1016/0006-8993(86)90887-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

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5.  17β-estradiol differentially regulates stress circuitry activity in healthy and depressed women.

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8.  The effect of chronic and acute stressors, and their interaction, on testes function: an experimental test during testicular recrudescence.

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Authors:  Derek Alsop; Jennifer S Ings; Mathilakath M Vijayan
Journal:  PLoS One       Date:  2009-07-31       Impact factor: 3.240

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