| Literature DB >> 35246374 |
Patrick R Smith1, Sapna C Pandit2, Sarah Loerch2, Zachary T Campbell3.
Abstract
In addition to their central functions in translation, ribosomes can adopt inactive structures that are fully assembled yet devoid of mRNA. We describe how the abundance of idle eukaryotic ribosomes is influenced by a broad range of biological conditions spanning viral infection, nutrient deprivation, and developmental cues. Vacant ribosomes may provide a means to exclude ribosomes from translation while also shielding them from degradation, and the variable identity of factors that occlude ribosomes may impart distinct functionality. We propose that regulated changes in the balance of idle and active ribosomes provides a means to fine-tune translation. We provide an overview of idle ribosomes, describe what is known regarding their function, and highlight questions that may clarify their biological roles.Entities:
Keywords: eEF2K; hibernating ribosome; idle ribosome; mTOR; vacant ribosome
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Year: 2022 PMID： 35246374 PMCID： PMC9106873 DOI： 10.1016/j.tibs.2022.02.003
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 14.264