Literature DB >> 35244686

B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS.

Sophia S Wang1, Claire M Vajdic2, Martha S Linet3, Susan L Slager4, Jenna Voutsinas1, Alexandra Nieters5, Delphine Casabonne6,7, James R Cerhan4, Wendy Cozen8, Graciela Alarcón9, Otoniel Martínez-Maza10,11,12, Elizabeth E Brown13,14, Paige M Bracci15, Jennifer Turner16,17, Henrik Hjalgrim18, Parveen Bhatti19, Yawei Zhang20, Brenda M Birmann21, Christopher R Flowers22, Ora Paltiel23, Elizabeth A Holly15, Eleanor Kane24, Dennis D Weisenburger25, Marc Maynadié26, Pierluigi Cocco27, Lenka Foretova28, Elizabeth Crabb Breen29, Qing Lan3, Angela Brooks-Wilson30, Anneclaire J De Roos31, Martyn T Smith32, Eve Roman24, Paolo Boffetta33,34, Anne Kricker35, Tongzhang Zheng36, Christine F Skibola22, Jacqueline Clavel37, Alain Monnereau37,38, Stephen J Chanock3, Nathaniel Rothman3, Yolanda Benavente6,7, Patricia Hartge3, Karin E Smedby39.   

Abstract

BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes.
METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression.
RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08-1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59-2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell-mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction.
CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL. ©2022 The Authors; Published by the American Association for Cancer Research.

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Year:  2022        PMID: 35244686      PMCID: PMC9081255          DOI: 10.1158/1055-9965.EPI-21-0875

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.090


  37 in total

1.  Medical history and risk of Hodgkin's and non-Hodgkin's lymphomas.

Authors:  A Tavani; C La Vecchia; S Franceschi; D Serraino; A Carbone
Journal:  Eur J Cancer Prev       Date:  2000-02       Impact factor: 2.497

2.  Medical history and risk for lymphoma: results of a population-based case-control study in Germany.

Authors:  Nikolaus Becker; Evelin Deeg; Thomas Rüdiger; Alexandra Nieters
Journal:  Eur J Cancer       Date:  2005-01       Impact factor: 9.162

3.  Increased frequency of hematopoietic malignancies in relatives of patients with lymphoid neoplasms: a French case-control study.

Authors:  Sara Villeneuve; Laurent Orsi; Alain Monnereau; Christian Berthou; Pierre Fenaux; Gerald Marit; Pierre Soubeyran; Françoise Huguet; Noël Milpied; Michel Leporrier; Denis Hemon; Xavier Troussard; Jacqueline Clavel
Journal:  Int J Cancer       Date:  2009-03-01       Impact factor: 7.396

Review 4.  High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma.

Authors:  Allison Rosenthal; Anas Younes
Journal:  Blood Rev       Date:  2016-09-30       Impact factor: 8.250

5.  Residential history, family characteristics and non-Hodgkin lymphoma, a population-based case-control study in the San Francisco Bay Area.

Authors:  Paige M Bracci; Tapashi B Dalvi; Elizabeth A Holly
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2006-07       Impact factor: 4.254

6.  Haematopoietic cancer and medical history: a multicentre case control study.

Authors:  P Vineis; P Crosignani; C Sacerdote; A Fontana; G Masala; L Miligi; O Nanni; V Ramazzotti; S Rodella; E Stagnaro; R Tumino; C Viganò; C Vindigni; A S Costantini
Journal:  J Epidemiol Community Health       Date:  2000-06       Impact factor: 3.710

7.  Medical history, lifestyle, family history, and occupational risk factors for marginal zone lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.

Authors:  Paige M Bracci; Yolanda Benavente; Jennifer J Turner; Ora Paltiel; Susan L Slager; Claire M Vajdic; Aaron D Norman; James R Cerhan; Brian C H Chiu; Nikolaus Becker; Pierluigi Cocco; Ahmet Dogan; Alexandra Nieters; Elizabeth A Holly; Eleanor V Kane; Karin E Smedby; Marc Maynadié; John J Spinelli; Eve Roman; Bengt Glimelius; Sophia S Wang; Joshua N Sampson; Lindsay M Morton; Silvia de Sanjosé
Journal:  J Natl Cancer Inst Monogr       Date:  2014-08

8.  Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancers.

Authors:  Nilanjan Chatterjee; Patricia Hartge; James R Cerhan; Wendy Cozen; Scott Davis; Naoko Ishibe; Joanne Colt; Lynn Goldin; Richard K Severson
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2004-09       Impact factor: 4.254

9.  Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset.

Authors:  Pouya Khankhanian; Pierre-Antoine Gourraud; Stacy J Caillier; Adam Santaniello; Stephen L Hauser; Sergio E Baranzini; Jorge R Oksenberg
Journal:  BMC Genomics       Date:  2010-11-10       Impact factor: 3.969

10.  Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

Authors:  Christine F Skibola; Sonja I Berndt; Joseph Vijai; Lucia Conde; Zhaoming Wang; Meredith Yeager; Paul I W de Bakker; Brenda M Birmann; Claire M Vajdic; Jia-Nee Foo; Paige M Bracci; Roel C H Vermeulen; Susan L Slager; Silvia de Sanjose; Sophia S Wang; Martha S Linet; Gilles Salles; Qing Lan; Gianluca Severi; Henrik Hjalgrim; Tracy Lightfoot; Mads Melbye; Jian Gu; Hervé Ghesquières; Brian K Link; Lindsay M Morton; Elizabeth A Holly; Alex Smith; Lesley F Tinker; Lauren R Teras; Anne Kricker; Nikolaus Becker; Mark P Purdue; John J Spinelli; Yawei Zhang; Graham G Giles; Paolo Vineis; Alain Monnereau; Kimberly A Bertrand; Demetrius Albanes; Anne Zeleniuch-Jacquotte; Attilio Gabbas; Charles C Chung; Laurie Burdett; Amy Hutchinson; Charles Lawrence; Rebecca Montalvan; Liming Liang; Jinyan Huang; Baoshan Ma; Jianjun Liu; Hans-Olov Adami; Bengt Glimelius; Yuanqing Ye; Grzegorz S Nowakowski; Ahmet Dogan; Carrie A Thompson; Thomas M Habermann; Anne J Novak; Mark Liebow; Thomas E Witzig; George J Weiner; Maryjean Schenk; Patricia Hartge; Anneclaire J De Roos; Wendy Cozen; Degui Zhi; Nicholas K Akers; Jacques Riby; Martyn T Smith; Mortimer Lacher; Danylo J Villano; Ann Maria; Eve Roman; Eleanor Kane; Rebecca D Jackson; Kari E North; W Ryan Diver; Jenny Turner; Bruce K Armstrong; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; Anthony Staines; James McKay; Angela R Brooks-Wilson; Tongzhang Zheng; Theodore R Holford; Saioa Chamosa; Rudolph Kaaks; Rachel S Kelly; Bodil Ohlsson; Ruth C Travis; Elisabete Weiderpass; Jacqueline Clavel; Edward Giovannucci; Peter Kraft; Jarmo Virtamo; Patrizio Mazza; Pierluigi Cocco; Maria Grazia Ennas; Brian C H Chiu; Joseph F Fraumeni; Alexandra Nieters; Kenneth Offit; Xifeng Wu; James R Cerhan; Karin E Smedby; Stephen J Chanock; Nathaniel Rothman
Journal:  Am J Hum Genet       Date:  2014-10-02       Impact factor: 11.043

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