Literature DB >> 35243066

Failure mode and effect analysis (FMEA) to identify and mitigate failures in a hospital rapid response system (RRS).

Ehsan Ullah1,2, Mirza Mansoor Baig3, Hamid GholamHosseini3, Jun Lu1,4,5,6,7.   

Abstract

We performed FMEA on the existing RRS with the help of routine users of the RRS who acted as subject matter experts and evaluated the failures for their criticality using the Risk Priority Number approach based on their experience of the RRS. The FMEA found 35 potential failure modes and 101 failure mode effects across 13 process steps of the RRS. The afferent limb of RRS was found to be more prone to these failures (62, 61.4%) than the efferent limb of the RRS (39, 38.6%). Modification of calling criteria (12, 11.9%) and calculation of New Zealand Early Warning Scores (NZEWS) calculation (11, 10.9%) steps were found to potentially give rise to the highest number of these failures. Causes of these failures include human error and related factors (35, 34.7%), staff workload/staffing levels (30, 29.7%) and limitations due to paper-based charts and organisational factors (n = 30, 29.7%). The demonstrated electronic system was found to potentially eliminate or reduce the likelihood of 71 (70.2%) failures. The failures not eliminated by the electronic RRS require targeted corrective measures including scenario-based training and education, and revised calling criteria to include triggers for hypothermia and high systolic blood pressure.
© 2022 Published by Elsevier Ltd.

Entities:  

Keywords:  Clinical deterioration; Early warning score; Failure modes and effects analysis; Rapid response system; Vital signs

Year:  2022        PMID: 35243066      PMCID: PMC8857483          DOI: 10.1016/j.heliyon.2022.e08944

Source DB:  PubMed          Journal:  Heliyon        ISSN: 2405-8440


Introduction

The Rapid Response System (RRS) as shown in Figure 1 acts as the surveillance mechanism used by healthcare organisations to monitor patients admitted to general hospital wards outside the critical care settings with repeated vital signs observations and Early Warning Scores such as NZEWS. The values of vital signs and NZEWS determine the escalation trigger or calling criteria i.e., when patients require escalation of care such as a rapid response by a Medical Emergency Team (MET) or equivalent [1].
Figure 1

Schematic representation of a RRS.

Schematic representation of a RRS. In New Zealand, most public hospitals use paper based vital signs charts in the general hospital ward settings to drive the afferent limb of the RRS, and a specialised team of nurses called Patient at-Risk (PaR) nurses and MET constitute the afferent limbs of the RRS [2]. The literature on the RRS from New Zealand and elsewhere have mainly reported the epidemiology of RRS activations [2, 3, 4, 5], outcomes of the in-hospital cardiac arrests [6, 7, 8] and comparison of various models of the RRS to recognise deteriorating patients in general hospital wards, outside critical care settings [9, 10]. There is a severe shortage of literature on how the RRS could be improved using systems approaches. We found only one publication using Root Cause Analysis to examine the causes of failures in patient monitoring and escalation of care for deteriorating patients [11]. Failure Mode and Effect Analysis (FMEA) has been widely used in high-risk industries to evaluate and mitigate process weaknesses [12, 13, 14, 15]. FMEA has been effectively applied to examine and mitigate risks and failure modes in many healthcare processes [16, 17]. FMEA has not been applied to systematically assess and address RRS failures despite such failures being widely reported [18, 19]. This study applies FMEA methodology to identify and address potential failures within an RRS.

Methods

Setting

The FMEA was performed at Taranaki Base Hospital, Taranaki District Health Board, New Plymouth, New Zealand between January and July 2021. The stages of the FMEA are shown in Figure 2.
Figure 2

Stages of the failure mode and effect analysis.

Stages of the failure mode and effect analysis.

Selection of high-risk process

RRS, as a unifying term to describe the process from vital signs monitoring to a rapid response type care delivered by MET or equivalent [20], was selected as the high-risk process for the FMEA study.

Selection of experts

FMEA methodology utilizes hands-on knowledge of the users of a process whereby a diverse group of users working on various parts of the process are recruited as subject matter experts (SMEs) to get insights into the potential ways a process may fail (failure modes). Then, these insights lead to the analysis of the effects of such failure modes, their frequency, and the ability of process controls on that frequency using standard FMEA framework. Therefore, SMEs doesn't represent a sample of users and no statistical tests are applied to validate selection of SMEs [12]. For this FMEA, we recruited six regular users of the RRS process as (SMEs who participated on a voluntary basis. Two SMEs were registered nurses (RNs), two were resident medical doctors, one was a specialised critical care outreach nurse, locally known as a ‘Patient-at-risk nurse or PAR nurse’ and one was a senior medical officer, a general physician or hospitalist. The SMEs attended a training session on FMEA methodology and participated in the demonstration of Vital Signs Monitoring and the Decision Support System [21] developed by Precision Driven Health – a system that automatically calculates NZEWS and has the ability to send alerts to cellular or landline phones and pager devices in a similar way the current paging system works for MET activations, and in addition enables them to view the vital signs values, trends and NZEWS on smartphones or tablet devices.

Mapping the process steps of RRS

A process diagram was drawn up to illustrate all the process steps of the existing rapid response system as shown in Figure 3.
Figure 3

Flow diagram of steps involved in a rapid response system.

Flow diagram of steps involved in a rapid response system.

Risk analysis

Potential failure mode effects were identified at each process step shown in Figure 3. The criticality of these failures was determined using a Risk Priority Number (RPN). A RPN is a numerical score quantifying the severity level (SL), occurrence level (OL) and detection level (DL) of failures according to the rating scale shown in Table 1 (RPN = severity x occurrence x detectability) of failures. The theoretical minimum RPN is 1∗1∗1 = 1. The theoretical maximum RPN is 3∗10∗5 = 150.
Table 1

Rating scale for severity, occurrence and detection of failure modes in a RRS.

Severity Levels (SL) of the Effect of the Failure ModesRating
No harm to patient/no effect on detection of patient deterioration1
Non-documented vital signs or NZEWS or incorrect calculated NZEWS2
Actual or potential delay to or lack of detection of patient deterioration3
Occurrence Level (OL) of the Failure ModesRating
Once in more than a year1
Once in a year2
Once in six months3
Once in three months4
Once a month5
Once a week6
Once every 3 days7
Once per day8
One per 8-hour shift9
More than once per 8-hour shift10
Detection Level (DL) of the Failure Modes when they occurRating
100% detection1
>50% detection2
11–50% detection3
<10 % detection4
0% detection5
Rating scale for severity, occurrence and detection of failure modes in a RRS. This rating scale (Table 1) was adapted from Rezaee et al., [22] and Buja et al., [23]. The RPN or criticality of a failure increases with higher severity and occurrence levels, and with lower detection levels. The SMEs assigned the SL, OL and DL to each failure mode effect based on their day-to-day experience about existing RRS activities at the study site.

Developing recommendations

The SMEs were asked whether the electronic system would eliminate or reduce the risk of failure modes identified within existing rapid response system components. The responses of the SMEs were recorded within FMEA data collection sheet. Specific recommendations were formulated targeting the failure modes of which the risk was not deemed to be eliminated or reduced by the electronic system.

Institutional review board statement

The study was conducted according to the guidelines of the Declaration of Helsinki and approved by Auckland University of Technology Ethics Committee (AUTEC) approved the research dated 13 March 2019, application number 19/37.

Results

The FMEA identified a total of 35 failure modes and 101 failure effects distributed over 13 process steps as shown in Table 2. Whether the demonstrated electronic RRS will potentially reduce or eliminate the risk and likelihood of these failures is also tabulated in the last column of Table 2.
Table 2

Failure modes, their effects and causes across the process steps of a RRS∗.

Serial NoProcess StepFailure ModeFailure Mode EffectsCausesRPNWill electronic RRS reduce the risk?
11.Timeliness of vital signs observationsDelay in undertaking vital signsDelay in detecting possible derangements in vital signs and/or NZEWS which may lead to delayed review and/or rapid response hence increased chances of adverse eventsLack of reinforcing function/mechanism to remind staff when vital sign observations become due based on patient's previous NZEWS value and/or minimum 4-hourly vital signs monitoring108No
2Non-compliance with protocols such as minimum 4-hourly vital signs monitoring on general wards108No
3Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission108No
42. Pulse Rate (PR)Non-measurement of the PRDelay in detecting possible derangements in vital signs and/or NZEWSToo busy staff or inadequate staff allocation, memory lapse120Yes
5Non-compliance with protocols such as minimum 4-hourly vital signs monitoring, and due to inability to calculate NZEWS score120Yes
6Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission120Yes
7Non-documentation of the PRDelay in detecting possible derangements in vital signs and/or NZEWSInterruptions due to other more urgent tasks18Yes
8Non-compliance with protocols18Yes
9Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission18Yes
10No trigger for rhythm abnormalitiesHeart rhythm abnormalities that do not cause haemodynamic instability are not recognised and managedNot included in the monitoring protocols25
113. Systolic blood pressure (SBP)Non-measurement of the SBPDelay in detecting possible derangements in vital signs and/or NZEWSIncorrect or less frequent measurements due to previous set of vital signs or NZEWS being miscalculated or staff not able to take measurement due to being busy, distracted or memory lapse or non-cooperation of patient120Yes
12Non-compliance with protocols120Yes
13Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission unless non-cooperation of patient is documented in clinical notes, if relevant120Yes
14Non-documentation of the SBPDelay in detecting possible derangements in vital signs and/or NZEWSInterruptions due to other more urgent tasks18Yes
15Non-compliance with protocols18Yes
16Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission unless non-cooperation of patient is documented in clinical notes, if relevant18Yes
17No trigger until too high SBPSignificant high Systolic BP (<220 mmHg) alone may continue for hours to days and could be indication of significant illness without any change in NZEWSProtocol definition issue90No
184.TemperatureNon-measurement of the temperatureDelay in detecting possible derangements in vital signs and/or NZEWSToo busy staff or inadequate staff allocation, memory lapse70No
19Non-compliance with protocols70No
20Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission70No
21Non-documentation of the temperatureDelay in detecting possible derangements in vital signs and/or NZEWSInterruptions due to other more urgent tasks12No
22Non-compliance with protocols12No
23Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission12No
24No trigger for hypothermiaSignificant illness such as sepsis may not be recognisedProtocol definition issue75No
255. Respiratory rate (RR)Non-measurement of the RRDelay in detecting possible derangements in vital signs and/or NZEWSToo busy staff or inadequate staff allocation, memory lapse120No
26Non-compliance with protocols120No
27Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission120No
28Errors in measurement the RRDelay in detecting possible derangements in vital signs and/or NZEWSInterruptions due to other more urgent tasks36No
29Non-compliance with protocols36No
30Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission36No
31Non-documentation of the RRDelay in detecting possible derangements in vital signs and/or NZEWSInterruptions due to other more urgent tasks18No
32Non-compliance with protocols18No
33Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission18No
346. Oxygen saturationNon-measurement of oxygen saturationDelay in detecting possible derangements in vital signs and/or NZEWSIncorrect or less frequent measurements due to previous set of vital signs or NZEWS being miscalculated or staff not able to take measurement due to being busy, inadequate staffing levels or memory lapse105Yes
35Non-compliance with protocols105Yes
36Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission105Yes
37Non-documentation of oxygen saturationDelay in detecting possible derangements in vital signs and/or NZEWSInterruptions due to other more urgent tasks18Yes
38Non-compliance with protocols18Yes
39Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission18Yes
407. Oxygen requirementNon-measurement of oxygen requirementDelay in detecting possible derangements in vital signs and/or NZEWSIncorrect or less frequent measurements due to previous set of vital signs or NZEWS being miscalculated or staff not able to take measurement due to being busy, distracted or memory lapse90Yes
41Non-compliance with protocols90Yes
42Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission90Yes
43Non-documentation of oxygen requirementDelay in detecting possible derangements in vital signs and/or NZEWSToo busy, interrupted by other more urgent task, memory lapse18Yes
44Non-compliance with protocols18Yes
45Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission18Yes
468. Level of consciousnessErrors in interpretation of the level of consciousnessDelay in detecting possible derangements in vital signs and/or NZEWSHuman error, complacency, lack of awareness of patient's sleeping pattern75No
47Non-compliance with protocols75No
48Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission75No
49Non-documentation of the level of consciousnessDelay in detecting possible derangements in vital signs and/or NZEWSToo busy staff or inadequate staff allocation, memory lapse72No
50Non-compliance with protocols72No
51Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission72No
529. NZEWS calculationNon-calculation of NZEWSDelay in detecting possible derangements in vital signs and/or NZEWSTime-consuming, difficult to calculate when staff working with huge cognitive load, interruptions135Yes
53Non-compliance with protocols135Yes
54Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission135Yes
55Incorrect calculation of NZEWSDelay in detecting possible derangements in vital signs and/or NZEWSTime-consuming, difficult to calculate when staff working with huge cognitive load, interruptions135Yes
56Non-compliance with protocols135Yes
57Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission135Yes
58Incorrect NZEWS calculated for type and age of patient such as adult NZEWS calculated when patient required a paediatric or maternal early warning score72
59Non-compliance with protocols72Yes
60Non-documentation of NZEWSDelay in detecting possible derangements in vital signs and/or NZEWSTime-consuming, difficult to calculate when staff working with huge cognitive load, interruptions150Yes
61Non-compliance with protocols150Yes
62Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission150Yes
6310. Escalation of careRevised frequency of observations does not match the NZEWS protocolDelay in detecting possible derangements in vital signs and/or NZEWSIncorrect or less frequent measurements due to previous set of vital signs or NZEWS being miscalculated or staff not able to take measurement due to being busy, distracted or memory lapse120Yes
64Non-compliance with protocols120Yes
65Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission120Yes
66Secondary responders are not informed about deterioration in a timely mannerDelay in detecting possible derangements in vital signs and/or NZEWSNeed to use phone or pager or task manager application, multiple devices and technology which creates inconsistency, causes delays in decision making90Yes
67Non-compliance with protocols90Yes
68Staff allocated to the patient is traceable through clinical records data and can be held responsible for this omission90Yes
69Secondary responders are not able to review patient in a timely mannerDelay in detecting possible derangements in vital signs and/or NZEWSLimited secondary responder resource, busy responding to other patients elsewhere, not involved in a timely manner105Yes
70Non-compliance with protocols105Yes
71Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response105Yes
7211. Modification of triggersNon documentation of modificationsDelay in detecting or respond to possible derangements in vital signs or NZEWS because of the masking effect of modificationsComplacency, lack of safety net/defensive barriers and culture105Yes
73Non-compliance with protocols105Yes
74Staff making inappropriate modifications, leaving incomplete documentation of the modifications, or not authorising the modifications at appropriate level of seniority may be held accountable105Yes
75Lack of sufficient space on NZEWS chart to document modifications every 24 hoursDelay in detecting or respond to possible derangements in vital signs or NZEWS because of the masking effect of modificationsPaper-based charts giving way documentation of modifications elsewhere in clinical records75Yes
76Non-compliance with protocols75Yes
77Staff making inappropriate modifications, leaving incomplete documentation of the modifications, or not authorising the modifications at an appropriate level of seniority may be held accountable75Yes
78Workarounds are common (modifications are validated for entire admission)Delay in detecting or respond to possible derangements in vital signs or NZEWS because of the masking effect of modificationsCulture, lack of interdisciplinary dialogue, lack of space on paper-based charts to accommodate frequent modifications, lack of reinforcing functions60No
79Non-compliance with protocols60No
80Staff making inappropriate modifications, leaving incomplete documentation of the modifications, or not authorising the modifications at an appropriate level of seniority may be held accountable60No
81Handwritten modification may be illegibleDelay in detecting or respond to possible derangements in vital signs or NZEWS because of the masking effect of modificationsPaper-based charts60Yes
82Non-compliance with protocols60Yes
83Staff making inappropriate modifications, leaving incomplete documentation of the modifications, or not authorising the modifications at an appropriate level of seniority may be held accountable60Yes
8412. Call to response timeLimited information shared by pager/phoneDelay in detecting possible derangements in vital signs and/or NZEWSTechnological limitation30Yes
85Non-compliance with protocols30Yes
86Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response30Yes
87Responder cannot access vital signs and NZEWS chart remotelyDelay in detecting possible derangements in vital signs and/or NZEWSPaper-based charts and technological limitation of the mode of communication used30Yes
88Non-compliance with protocols30Yes
89Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response30Yes
90Non-documentation of call to response timeDelay in detecting possible derangements in vital signs and/or NZEWSPaper-based charts, documentation also paper based and is separated physically from NZEWS charts and likely to be missed in busy environment90Yes
91Non-compliance with protocols90Yes
92Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response90Yes
9313. Secondary responseLimited information shared by pager/phone and rarely a phone advice only is appropriateDelay in detecting possible derangements in vital signs and/or NZEWSPaper-based charts and technological limitation of the mode of communication used30Yes
94Non-compliance with protocols30Yes
95Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response30Yes
96Secondary responders do not communicate or initiate actions remotelyDelay in detecting possible derangements in vital signs and/or NZEWSPaper-based charts, complex information, not suitable to be effectively communicated by phone call and pager system not capable of passing long messages60Yes
97Non-compliance with protocols60Yes
98Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response60Yes
99Non-documentation of the actions taken by secondary responderNon-availability of the actions undertaken by one staff member to another, leading to delays in response and/or duplication of workPaper-based charts, documentation also paper based and is separated physically from NZEWS charts and likely to be missed in busy environment45Yes
100Non-compliance with protocols45Yes
101Staff who are paged, tasked, or sent a RRS activation call (777 call) are traceable and could be held accountable for delayed review or response45Yes

Authors plan to calculate RPN for each failure mode post implementation of electronic RRS for comparison when/if this is possible.

Failure modes, their effects and causes across the process steps of a RRS∗. Authors plan to calculate RPN for each failure mode post implementation of electronic RRS for comparison when/if this is possible. The most common causes of the failure modes (n = 35, 34.7%) were related to human error, memory lapses, lack of reinforcement or reminders. Another 30 (29.7%) failures were related to staffing levels, too busy staff/workload, and work-related interruptions. The third largest group of failures (n = 30, 29.7%) was caused by limitations of paper-based vital signs charts, technological limitations of modes of communication, organisational culture, workarounds, and other organisational factors. A small proportion of failures was caused by mere task complexity (3, 3%) and protocol weaknesses (3, 3%). The demonstrated electronic system was assessed by the SMEs against each failure to determine whether it could potentially eliminate or reduce the likelihood of those failures. The response of the SMEs was recorded and presented against the process step as summarised in Table 3 which shows that the demonstrated electronic system could potentially eliminate or reduce the likelihood of 71 (70.2%) failures.
Table 3

Elimination or reduction of failures by demonstrated electronic system across process steps.

Process stepsAll failures
EliminatedNot eliminateSub-total
1. Timing of vital signs033
2. Heart Rate617
3. Blood pressure617
4.Temperature077
5. Respiratory rate099
6. Oxygen saturation606
7. Oxygen requirement606
8. Level of consciousness066
9. NZEWS calculation11011
10. Escalation of care909
11. Modification of calling criteria9312
12. Accessing afferent inputs (by responders)909
13. Timeliness and documentation of rapid response909
Total7130101
Elimination or reduction of failures by demonstrated electronic system across process steps.

Discussion and recommendations

We reported the first FMEA applied to identify failures, determine their criticality, locate those to the process steps and limbs of RRS, and decide whether those failures could be eliminated or reduced by the electronic system or other specific measures. We found that some process steps of the RRS tend to encounter a higher number of failures whereas failures at other process steps have a higher tendency to be critical failures. We saw the afferent limb of the RRS as a more failure-prone component, and relatively less likely to be rendered free of critical failures by implementation of an electronic system alone. The root cause analysis of 49 unplanned critical care admissions by van Galen et al. [11] found that 46% of the root causes were human-related, which predominantly included failures within monitoring and interventions. The FMEA presented in the current report shows that 48% of the critical failures and over 34% of the total failures were related to memory lapses/human errors. The majority of failures (>60%) in our study were found within the monitoring/afferent limb of the RRS. Other findings of van Galen et al. are not suitable for comparison with our findings and vice versa, yet van Galen et al. seem to be the only relevant literature for us to compare a small portion of our findings with. This means we present unique insights into RRS through FMEA which will help adoption of electronic RRS to replace the RRS utilizing paper-based vital signs and early warning score charts and offers to point out the failures which may not be addressed by implementing electronic RRS alone, and hence require specific remedial actions at policy or procedure level. Following paragraphs elaborate these points. As shown in the Results section, the demonstrated electronic system offers eliminating or reducing the likelihood of a majority (71, 70.3%) of the failures within the existing RRS which is driven by paper-based vital signs charts. The electronic system would eliminate or reduce these failures by reducing human error in simple calculations, applying calling criteria and activating MET upon meeting the criteria, and possibly by adding reminders or reinforcements for staff to undertake vital signs observations. The electronic system would reduce delays in response by enabling remote access to vital signs charts and removing the need to locate paper charts in time-critical situations. We recommend using an electronic system similar to the demonstrated electronic system [21] to replace paper-based vital sign charts as it offers mitigation of the majority of failures encountered in the RRS driven by paper charts. Implementing any change should follow evidence-based methods [24] and take into account lessons learnt from similar implementations elsewhere [25] if applicable. The failures not addressed by the electronic system, e.g., delay in undertaking vital signs; lack of triggers for hypothermia (potential failure to recognise serious illness such as sepsis [26]) and systolic blood pressure (no trigger until SBP is above 220 mmHg [27]); and omissions, lack of measurement and recording of respiratory rate and the level of consciousness were related to the afferent limb of the RRS – another finding that matches the Root Cause Analysis presented by van Galen et al. [11]. We propose that the delay in vital signs observations could possibly be reduced by adding a reminder within the electronic system about the timing of the next set of vital signs observations, or by choosing an electronic system that measures all vital signs automatically. In this regard, the authors have reviewed electronic RRS applications [28] and have provided a summary of the features and functionalities of each application. We propose that the education and training with scenario-based learning and simulation could mitigate the failures associated with assessment of respiratory rate and the level of consciousness. We suggest that the two protocol-related failures (lack of triggers for hypothermia and high SBP) should be considered at the time of future revision of the NZEWS protocols. We think increasing the frequency of internal and external audits, mandating reporting of error and omission rates and patient monitoring might add to the workload – a factor involved in about one third of failures and therefore we do not recommend these measures.

Declarations

Author contribution statement

Ehsan Ullah: Conceived and designed the experiments; Performed the experiments; Analyzed and interpreted the data; Contributed reagents, materials, analysis tools or data; Wrote the paper. Mirza Mansoor Baig and Hamid GholamHosseini: Conceived and designed the experiments; Wrote the paper. Jun Lu: Conceived and designed the experiments; Contributed reagents, materials, analysis tools or data; Wrote the paper.

Funding statement

This work was supported by Auckland University of Technology.

Data availability statement

Data will be made available on request.

Declaration of interests statement

The authors declare no conflict of interest.

Additional information

No additional information is available for this paper.
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