Kei Wada1, Munemitsu Kawano1, Yuichi Hemmi1, Reiji Suzuki2, Katsunori Kunoki1, Hiroshi Sakagami3, Hiroshi Kawazu4, Satoshi Yokose5. 1. Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan. 2. Division of Oral Rehabilitation, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan. 3. Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan. 4. Section of Continuous Education, School of Dentistry, Meikai University, Saitama, Japan. 5. Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan; s-yokose@dent.meikai.ac.jp.
Abstract
BACKGROUND/AIM: The aim of this study was to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) on bone metabolism during the healing period in rat tibiae bone defects using micro-computed tomography (micro CT) imaging for three-dimensional morphological evaluation. MATERIALS AND METHODS: The right tibia received ultrasound exposure (US group) every day, whereas the opposite side served as a control (Control group). At 1, 2, and 3 weeks after the operation, micro CT was performed, and the volume and surface area of new bone formation in the bone defects was evaluated three-dimensionally. RESULTS: Bone volume (BV) and bone surface (BS) in the tibiae of both the US and Control groups demonstrated the highest values 1 week after the operation, with no significant differences between the groups. At 2 weeks after the operation, the BV and BS values in both groups had decreased, but the decrease was smaller in the US group than the Control group. At 3 weeks after the operation, the BV and BS values in the Control group were significantly lower than those in the US group. CONCLUSION: LIPUS stimulation can prevent bone loss during the healing of bone defects.
BACKGROUND/AIM: The aim of this study was to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) on bone metabolism during the healing period in rat tibiae bone defects using micro-computed tomography (micro CT) imaging for three-dimensional morphological evaluation. MATERIALS AND METHODS: The right tibia received ultrasound exposure (US group) every day, whereas the opposite side served as a control (Control group). At 1, 2, and 3 weeks after the operation, micro CT was performed, and the volume and surface area of new bone formation in the bone defects was evaluated three-dimensionally. RESULTS: Bone volume (BV) and bone surface (BS) in the tibiae of both the US and Control groups demonstrated the highest values 1 week after the operation, with no significant differences between the groups. At 2 weeks after the operation, the BV and BS values in both groups had decreased, but the decrease was smaller in the US group than the Control group. At 3 weeks after the operation, the BV and BS values in the Control group were significantly lower than those in the US group. CONCLUSION: LIPUS stimulation can prevent bone loss during the healing of bone defects.
Authors: Nandkumar M Rawool; Barry B Goldberg; Flemming Forsberg; Alan A Winder; Eric Hume Journal: J Ultrasound Med Date: 2003-02 Impact factor: 2.153
Authors: Michael E Hantes; Alexandros N Mavrodontidis; Charalampos G Zalavras; Apostolos H Karantanas; Theofilos Karachalios; Konstantinos N Malizos Journal: J Bone Joint Surg Am Date: 2004-10 Impact factor: 5.284