| Literature DB >> 35239393 |
Hongjie Li1,2,3, Jasper Janssens4,5, Maxime De Waegeneer4,5, Sai Saroja Kolluru6,7,8, Kristofer Davie4, Vincent Gardeux9,10, Wouter Saelens9,10, Fabrice P A David9,10,11, Maria Brbić8,12, Katina Spanier4,5, Jure Leskovec8,12, Colleen N McLaughlin1, Qijing Xie1, Robert C Jones6,7,8, Katja Brueckner13, Jiwon Shim14, Sudhir Gopal Tattikota15,16, Frank Schnorrer17, Katja Rust18,19, Todd G Nystul19, Zita Carvalho-Santos20, Carlos Ribeiro20, Soumitra Pal21, Sharvani Mahadevaraju22, Teresa M Przytycka21, Aaron M Allen23, Stephen F Goodwin23, Cameron W Berry24, Margaret T Fuller24, Helen White-Cooper25, Erika L Matunis26, Stephen DiNardo27,28, Anthony Galenza29, Lucy Erin O'Brien29, Julian A T Dow30, Heinrich Jasper31, Brian Oliver22, Norbert Perrimon15,16, Bart Deplancke9,10, Stephen R Quake6,7,8, Liqun Luo1, Stein Aerts4,5, Devika Agarwal32, Yasir Ahmed-Braimah33, Michelle Arbeitman34, Majd M Ariss35, Jordan Augsburger13, Kumar Ayush12, Catherine C Baker36, Torsten Banisch37, Katja Birker38, Rolf Bodmer38, Benjamin Bolival36, Susanna E Brantley36, Julie A Brill39,40, Nora C Brown41, Norene A Buehner41, Xiaoyu Tracy Cai31, Rita Cardoso-Figueiredo20, Fernando Casares42, Amy Chang43, Thomas R Clandinin44, Sheela Crasta6,7,8, Claude Desplan45, Angela M Detweiler8, Darshan B Dhakan20, Erika Donà46, Stefanie Engert43, Swann Floc'hlay4,5, Nancy George47, Amanda J González-Segarra43, Andrew K Groves3,48, Samantha Gumbin29, Yanmeng Guo49,50, Devon E Harris36, Yael Heifetz51, Stephen L Holtz52, Felix Horns53, Bruno Hudry54, Ruei-Jiun Hung15, Yuh Nung Jan49,50, Jacob S Jaszczak49,50, Gregory S X E Jefferis46, Jim Karkanias8, Timothy L Karr55, Nadja Sandra Katheder31, James Kezos38, Anna A Kim29,56,57, Seung K Kim24,58, Lutz Kockel24, Nikolaos Konstantinides59, Thomas B Kornberg60, Henry M Krause61, Andrew Thomas Labott29, Meghan Laturney43, Ruth Lehmann62, Sarah Leinwand43, Jiefu Li1, Joshua Shing Shun Li15, Kai Li49,50, Ke Li49,50, Liying Li49,50, Tun Li49,50, Maria Litovchenko9,10, Han-Hsuan Liu49,50, Yifang Liu15, Tzu-Chiao Lu2, Jonathan Manning47, Anjeli Mase13, Mikaela Matera-Vatnick41, Neuza Reis Matias36, Caitlin E McDonough-Goldstein63,64, Aaron McGeever8, Alex D McLachlan65, Paola Moreno-Roman29, Norma Neff8, Megan Neville23, Sang Ngo29, Tanja Nielsen38, Caitlin E O'Brien49,50, David Osumi-Sutherland66, Mehmet Neset Özel67, Irene Papatheodorou47, Maja Petkovic49,50, Clare Pilgrim68, Angela Oliveira Pisco8, Carolina Reisenman43, Erin Nicole Sanders29, Gilberto Dos Santos69, Kristin Scott43, Aparna Sherlekar29, Philip Shiu43, David Sims32, Rene V Sit8, Maija Slaidina70, Harold E Smith71, Gabriella Sterne43, Yu-Han Su29, Daniel Sutton72, Marco Tamayo38, Michelle Tan8, Ibrahim Tastekin20, Christoph Treiber73, David Vacek1, Georg Vogler38, Scott Waddell73, Wanpeng Wang60, Rachel I Wilson52, Mariana F Wolfner41, Yiu-Cheung E Wong36, Anthony Xie1, Jun Xu15, Shinya Yamamoto3,74, Jia Yan8, Zepeng Yao43, Kazuki Yoda29, Ruijun Zhu49,50, Robert P Zinzen75.
Abstract
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.Entities:
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Year: 2022 PMID： 35239393 PMCID： PMC8944923 DOI： 10.1126/science.abk2432
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714