Literature DB >> 3523481

Extracellular localization of pokeweed antiviral protein.

M P Ready, D T Brown, J D Robertus.   

Abstract

Pokeweed antiviral protein is an enzyme of Mr 29,000 known to inactivate a wide variety of eukaryotic ribosomes. We have used electron microscopy to show that the antibody specific for the protein is bound within the cell wall matrix of leaf mesophyll cells from Phytolacca americana. Any penetration or breakage of the cell wall and membrane could allow the enzyme to enter the cytoplasm, where it is likely to inhibit protein synthesis in the damaged cell. We speculate that pokeweed antiviral protein is a defensive agent whose principal function is probably antiviral.

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Year:  1986        PMID： 3523481      PMCID： PMC323888          DOI： 10.1073/pnas.83.14.5053

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Purification and partial characterization of the antiviral protein from Phytolacca americana which inhibits eukaryotic protein synthesis.

Authors:  J D Irvin
Journal:  Arch Biochem Biophys       Date:  1975-08       Impact factor: 4.013

2.  Inhibition of poliovirus replication by a plant antiviral peptide.

Authors:  M A Ussery; J D Irvin; B Hardesty
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

3.  Differential ricin sensitivity of rat liver and wheat germ ribosomes in polyuridylic acid translation.

Authors:  D B Cawley; M L Hedblom; E J Hoffman; L L Houston
Journal:  Arch Biochem Biophys       Date:  1977-08       Impact factor: 4.013

4.  A possible mechanism for the inhibition of plant viruses by a peptide from Phytolacca americana.

Authors:  R A Owens; G Bruening; R J Shepherd
Journal:  Virology       Date:  1973-11       Impact factor: 3.616

5.  Ricin-like plant toxins are evolutionarily related to single-chain ribosome-inhibiting proteins from Phytolacca.

Authors:  M Ready; K Wilson; M Piatak; J D Robertus
Journal:  J Biol Chem       Date:  1984-12-25       Impact factor: 5.157

6.  Ricin B chain and discoidin I share a common primitive protein fold.

Authors:  J D Robertus; M P Ready
Journal:  J Biol Chem       Date:  1984-11-25       Impact factor: 5.157

7.  Requirements for antiribosomal activity of pokeweed antiviral protein.

Authors:  M Ready; S Bird; G Rothe; J D Robertus
Journal:  Biochim Biophys Acta       Date:  1983-05-20

8.  Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A.

Authors:  F Stirpe; S Olsnes; A Pihl
Journal:  J Biol Chem       Date:  1980-07-25       Impact factor: 5.157

9.  Ricin inhibition of in vitro protein synthesis by plant ribosomes.

Authors:  S M Harley; H Beevers
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

10.  Protein bodies of castor bean endosperm: isolation, fractionation, and the characterization of protein components.

Authors:  R E Tully; H Beevers
Journal:  Plant Physiol       Date:  1976-12       Impact factor: 8.340
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  37 in total

1.  A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: plants apparently contain a suicide system directed at ribosomes.

Authors:  K Madin; T Sawasaki; T Ogasawara; Y Endo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

2.  Inhibition of pokeweed antiviral protein (PAP) by turnip mosaic virus genome-linked protein (VPg).

Authors:  Artem V Domashevskiy; Hiroshi Miyoshi; Dixie J Goss
Journal:  J Biol Chem       Date:  2012-07-06       Impact factor: 5.157

Review 3.  Ribosome-inactivating proteins in plant biology.

Authors:  Sang-Wook Park; Ramarao Vepachedu; Neelam Sharma; Jorge M Vivanco
Journal:  Planta       Date:  2004-09-03       Impact factor: 4.116

4.  Tissue culture of endod (Phytolacca dodecandra L'Herit): growth and production of ribosome-inactivating proteins.

Authors:  M S Bonness; T J Mabry
Journal:  Plant Cell Rep       Date:  1992-03       Impact factor: 4.570

5.  Protoplasts from Phytolacca dodecandra L'Herit (endod) and P. americana L. (pokeweed).

Authors:  P E Koch; M S Bonness; H Lu; T J Mabry
Journal:  Plant Cell Rep       Date:  1996-08       Impact factor: 4.570

6.  Reduced toxicity and broad spectrum resistance to viral and fungal infection in transgenic plants expressing pokeweed antiviral protein II.

Authors:  P Wang; O Zoubenko; N E Tumer
Journal:  Plant Mol Biol       Date:  1998-12       Impact factor: 4.076

7.  Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A).

Authors:  L Barbieri; P Valbonesi; E Bonora; P Gorini; A Bolognesi; F Stirpe
Journal:  Nucleic Acids Res       Date:  1997-02-01       Impact factor: 16.971

8.  A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template.

Authors:  K A Hudak; P Wang; N E Tumer
Journal:  RNA       Date:  2000-03       Impact factor: 4.942

9.  C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes.

Authors:  N E Tumer; D J Hwang; M Bonness
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

10.  Isolation and characterization of a novel ribosome-inactivating protein from root cultures of pokeweed and its mechanism of secretion from roots.

Authors:  Sang-Wook Park; Christopher B Lawrence; James C Linden; Jorge M Vivanco
Journal:  Plant Physiol       Date:  2002-09       Impact factor: 8.340
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