Literature DB >> 3522331

Production and characterization of a monoclonal islet cell surface autoantibody from the BB rat.

C H Brogren, F Hirsch, P Wood, P Druet, P Poussier.   

Abstract

Islet cell surface autoantibodies are present in the serum of the spontaneously diabetic BB rat. The availability in large quantities of such autoantibodies should help us understand their significance in vivo. Fusions between BB rat lymphocytes and rat myeloma cells were screened by cellular enzyme linked immunosorbent assay and indirect immunofluorescence on rat living cells. They resulted in a stable hybridoma, called IC2, secreting a monoclonal immunoglobulin M specific for the surface of rat islet cells. This monoclonal antibody was found to bind to the surface of 56% normal rat islet cells and 72% rat insulinoma cells. Protease treatment of rat islet cells resulted in a subsequent 72-100% binding inhibition of IC2 to the surface of these cells, suggesting that IC2 specific antigen is a protein.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3522331     DOI： 10.1007/bf00452071

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  19 in total

1.  "Cytoplasmic" islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate.

Authors:  R C Nayak; M A Omar; A Rabizadeh; S Srikanta; G S Eisenbarth
Journal:  Diabetes       Date:  1985-06       Impact factor: 9.461

2.  Autoimmunity and type I (insulin-dependent) diabetes mellitus.

Authors:  A Naji; W K Silvers; C F Barker
Journal:  Transplantation       Date:  1983-10       Impact factor: 4.939

3.  Human monoclonal autoantibodies that react with multiple endocrine organs.

Authors:  J Satoh; B S Prabhakar; M V Haspel; F Ginsberg-Fellner; A L Notkins
Journal:  N Engl J Med       Date:  1983-07-28       Impact factor: 91.245

4.  Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG.

Authors:  G Galfrè; C Milstein; B Wright
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

5.  Production of monoclonal antibodies to islet cell surface antigens using hybridization of spleen lymphocytes from non-obese diabetic mice.

Authors:  K Yokono; K Shii; J Hari; S Yaso; Y Imamura; K Ejiri; K Ishihara; S Fujii; T Kazumi; H Taniguchi
Journal:  Diabetologia       Date:  1984-05       Impact factor: 10.122

6.  Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat.

Authors:  T Dyrberg; P Poussier; F Nakhooda; E B Marliss; A Lernmark
Journal:  Diabetologia       Date:  1984-02       Impact factor: 10.122

7.  Islet-cell-surface antibodies in juvenile diabetes mellitus.

Authors:  A Lernmark; Z R Freedman; C Hofmann; A H Rubenstein; D F Steiner; R L Jackson; R J Winter; H S Traisman
Journal:  N Engl J Med       Date:  1978-08-24       Impact factor: 91.245

8.  Preferential lysis of pancreatic B-cells by islet cell surface antibodies.

Authors:  M J Dobersen; J E Scharff
Journal:  Diabetes       Date:  1982-05       Impact factor: 9.461

9.  Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells.

Authors:  G S Eisenbarth; K Shimizu; M A Bowring; S Wells
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

10.  Breeding of a non-obese, diabetic strain of mice.

Authors:  S Makino; K Kunimoto; Y Muraoka; Y Mizushima; K Katagiri; Y Tochino
Journal:  Jikken Dobutsu       Date:  1980-01
View more
  13 in total

1.  Enrichment of beta cells from the human fetal pancreas by fluorescence activated cell sorting with a new monoclonal antibody.

Authors:  R R de Krijger; H J Aanstoot; G Kranenburg; A Verkerk; J F Jongkind; R van Strik; K J Lafferty; G J Bruining
Journal:  Diabetologia       Date:  1992-05       Impact factor: 10.122

2.  Getting beta all the time: discovery of reliable markers of beta cell mass.

Authors:  J C Hutton; H W Davidson
Journal:  Diabetologia       Date:  2010-04-22       Impact factor: 10.122

3.  Monoclonal antibody-mediated cytotoxicity against rat beta cells detected in vitro does not cause beta-cell destruction in vivo.

Authors:  B Ziegler; S Lucke; E Köhler; B Hehmke; M Schlosser; S Witt; W Besch; M Ziegler
Journal:  Diabetologia       Date:  1992-07       Impact factor: 10.122

4.  Unique sphingomyelin patches are targets of a beta-cell-specific antibody.

Authors:  Amol Kavishwar; Zdravka Medarova; Anna Moore
Journal:  J Lipid Res       Date:  2011-07-11       Impact factor: 5.922

Review 5.  Molecular imaging of β-cells: diabetes and beyond.

Authors:  Weijun Wei; Emily B Ehlerding; Xiaoli Lan; Quan-Yong Luo; Weibo Cai
Journal:  Adv Drug Deliv Rev       Date:  2018-07-03       Impact factor: 15.470

6.  A new view of the beta cell.

Authors:  J Ahnfelt-Rønne; J Hecksher-Sørensen; L Schäffer; O D Madsen
Journal:  Diabetologia       Date:  2012-07-18       Impact factor: 10.122

7.  Pancreatic islet and progenitor cell surface markers with cell sorting potential.

Authors:  J Hald; T Galbo; C Rescan; L Radzikowski; A E Sprinkel; H Heimberg; J Ahnfelt-Rønne; J Jensen; R Scharfmann; G Gradwohl; K H Kaestner; C Stoeckert; J N Jensen; O D Madsen
Journal:  Diabetologia       Date:  2011-09-23       Impact factor: 10.122

8.  Characterization of monoclonal islet cell reactive autoantibodies from the diabetic biobreeding (BB/OK) rat.

Authors:  B Ziegler; S Witt; K D Kohnert; M Schlosser; P Augstein; D Michaelis; I Klöting; M Ziegler
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

Review 9.  Advances in beta-cell imaging.

Authors:  Anna Moore
Journal:  Eur J Radiol       Date:  2009-03-03       Impact factor: 3.528

10.  Imaging the Beta-cell mass: why and how.

Authors:  Frantisek Saudek; Carl-Henrik Brogren; Srirang Manohar
Journal:  Rev Diabet Stud       Date:  2008-05-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.