| Literature DB >> 35219848 |
Guangjie Cheng1, Ruizheng Shi2.
Abstract
Heme-containing peroxidases catalyze the oxidation of a variety of substrates by consuming hydrogen peroxide (H2O2), and play diversified roles in physiology and pathology including innate immunity, the synthesis of thyroid hormone and the extracellular matrix, as well as the pathogenesis of several inflammatory diseases. Peroxidasin (PXDN), also known as Vascular Peroxidase-1 (VPO1), is a newly identified peroxidase and expresses in multiple cells and tissues including cardiovascular system and the lung. Recent studies imply its roles in the innate immunity, cardiovascular physiology and diseases, and extracellular matrix formation. Studies on the role of PXDN in human diseases are entering a new and exciting stage, and this review provides the insights into this emerging field of PXDN.Entities:
Keywords: Cardiovascular disease; Cell signaling; Enzyme; Gene mutation; Heme Peroxidase; Innate immunity; Pathology; Peroxidasin; Physiology
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Year: 2022 PMID： 35219848 PMCID： PMC8957557 DOI： 10.1016/j.freeradbiomed.2022.02.026
Source DB: PubMed Journal: Free Radic Biol Med ISSN： 0891-5849 Impact factor: 7.376