Bo-Een Hwang1,2, Jae-Hyuck Kwak1,2, Joo-Young Kim1,2, Rae-Young Kim1,2, Mirinae Kim1,2, Young-Geun Park1,2, Young-Hoon Park3,4. 1. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. 2. Catholic Institute for Visual Science, The Catholic University of Korea School of Medicine, Seoul, Republic of Korea. 3. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. parkyh@catholic.ac.kr. 4. Catholic Institute for Visual Science, The Catholic University of Korea School of Medicine, Seoul, Republic of Korea. parkyh@catholic.ac.kr.
Abstract
PURPOSE: To evaluate the choriocapillaris (CC) flow in central serous chorioretinopathy (CSC) and determine the relationship between CC flow void with the choroidal thickness (CT) and choroidal vascularity index (CVI). METHODS: Retrospective analysis of 20 patients with CSC (40 eyes, including unaffected fellow eyes) and 20 age- and sex-matched controls. After compensation with optical coherence tomography (OCT) en-face structural image, the CC flow void (%) was measured using the phansalkar threshold with a window radius of 3 and 15 pixels. The mean CC flow voids of acute CSC, recovered-acute CSC, unaffected fellow, and control eyes were compared by matched data analysis. A regression analysis was performed on the choroidal parameters (CT and CVI) and CC flow voids. RESULTS: The CC flow void had an increasing tendency in the following order: control, fellow, recovered-acute CSC, and acute CSC eyes. Acute/recovered comparison showed a significant P value (0.008) in the foveal lesion. Recovered/fellow and fellow/control presented significant P values regardless of location to fovea (all <0.05). There were significant positive correlations between CT and CC flow void (P < 0.05) in the acute CSC, recovered-acute CSC eyes. CONCLUSION: The CC flow on OCT angiography decreased in acute CSC eyes, especially in the foveal lesion, with a published compensation method. The findings suggest that unmodulated choroidal blood flow contributed to partially reversible diminished CC flow.
PURPOSE: To evaluate the choriocapillaris (CC) flow in central serous chorioretinopathy (CSC) and determine the relationship between CC flow void with the choroidal thickness (CT) and choroidal vascularity index (CVI). METHODS: Retrospective analysis of 20 patients with CSC (40 eyes, including unaffected fellow eyes) and 20 age- and sex-matched controls. After compensation with optical coherence tomography (OCT) en-face structural image, the CC flow void (%) was measured using the phansalkar threshold with a window radius of 3 and 15 pixels. The mean CC flow voids of acute CSC, recovered-acute CSC, unaffected fellow, and control eyes were compared by matched data analysis. A regression analysis was performed on the choroidal parameters (CT and CVI) and CC flow voids. RESULTS: The CC flow void had an increasing tendency in the following order: control, fellow, recovered-acute CSC, and acute CSC eyes. Acute/recovered comparison showed a significant P value (0.008) in the foveal lesion. Recovered/fellow and fellow/control presented significant P values regardless of location to fovea (all <0.05). There were significant positive correlations between CT and CC flow void (P < 0.05) in the acute CSC, recovered-acute CSC eyes. CONCLUSION: The CC flow on OCT angiography decreased in acute CSC eyes, especially in the foveal lesion, with a published compensation method. The findings suggest that unmodulated choroidal blood flow contributed to partially reversible diminished CC flow.
Authors: Qinqin Zhang; Fang Zheng; Elie H Motulsky; Giovanni Gregori; Zhongdi Chu; Chieh-Li Chen; Chunxia Li; Luis de Sisternes; Mary Durbin; Philip J Rosenfeld; Ruikang K Wang Journal: Invest Ophthalmol Vis Sci Date: 2018-01-01 Impact factor: 4.799
Authors: Bertan Cakir; Michael Reich; Stefan Lang; Anima Bühler; Christoph Ehlken; Bastian Grundel; Milena Stech; Sabine Reichl; Andreas Stahl; Daniel Böhringer; Hansjürgen Agostini; Clemens Lange Journal: Ophthalmol Ther Date: 2019-01-07
Authors: Michael Reich; Daniel Böhringer; Bertan Cakir; Felicitas Bucher; Moritz Daniel; Stefan Lang; Wolf Lagrèze; Hansjürgen Agostini; Clemens Lange Journal: Ophthalmol Ther Date: 2019-10-25