| Literature DB >> 32407978 |
Rebecca Kaye1, Shruti Chandra2, Jay Sheth3, Camiel J F Boon4, Sobha Sivaprasad2, Andrew Lotery5.
Abstract
Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging.Entities:
Keywords: Central serous chorioretinopathy (CSC); Choroid; Choroidal endothelial cells (CECs); Complement factor H (CFH); Corticosteroids; Eplerenone; Hyperpermeability; Mineralocorticoids; Pachychoroid; Retinal pigment epithelium (RPE)
Mesh:
Year: 2020 PMID: 32407978 DOI: 10.1016/j.preteyeres.2020.100865
Source DB: PubMed Journal: Prog Retin Eye Res ISSN: 1350-9462 Impact factor: 21.198