Lynn P Lowe1, Amanda M Perak2, Alan Kuang1, Donald M Lloyd-Jones1, David A Sacks3, Chaicharn Deerochanawong4, Michael Maresh5, Ronald C Ma6, William L Lowe1, Boyd E Metzger1, Denise M Scholtens1. 1. Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 2. Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Electronic address: amarma@luriechildrens.org. 3. Kaiser Permanente of Southern California, Pasadena, CA, USA. 4. Rajavithi Hospital, Bangkok, Thailand. 5. Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom. 6. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Abstract
AIMS: To examine associations of pregnancy glycemia with future dyslipidemia. METHODS: We analyzed data from Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study participants. We examined associations of gestational diabetes (GDM), sum of fasting, 1-hour, and 2-hour glucose z-scores after 75-g load, insulin sensitivity, and lipid levels at 24-32 weeks' gestation with dyslipidemia 10-14 years postpartum. RESULTS: Among 4,693 women, 14.3% had GDM. At follow-up, mean (SD) age was 41.7 (5.7) years, 32.3% had total cholesterol (TC) ≥ 5.17, 27.2% had HDL cholesterol < 1.29, 22.4% had LDL cholesterol (LDL-C) ≥ 3.36, 10.9% had triglycerides ≥ 1.69 mmol/L, and 2.9% had type 2 diabetes. After covariate adjustment, pregnancy glycemic measures were associated with all follow-up dyslipidemias. After additional adjustment for pregnancy lipids, GDM remained associated with TC ≥ 5.17 mmol/L (odds ratio [95% CI], 1.63 [1.22-2.18]) and LDL-C ≥ 3.36 mmol/L (1.63 [1.20-2.22]), even in the absence of type 2 diabetes development (1.55 [1.15-2.10] and 1.56 [1.13-2.16], respectively). Continuous glycemic measures in pregnancy were significantly associated with all follow-up dyslipidemias, independent of pregnancy lipids and type 2 diabetes. CONCLUSIONS: Pregnancy glycemia was associated with dyslipidemia 10-14 years later, independent of pregnancy lipid levels and in the absence of type 2 diabetes development. Lipid screening after GDM deserves special consideration.
AIMS: To examine associations of pregnancy glycemia with future dyslipidemia. METHODS: We analyzed data from Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study participants. We examined associations of gestational diabetes (GDM), sum of fasting, 1-hour, and 2-hour glucose z-scores after 75-g load, insulin sensitivity, and lipid levels at 24-32 weeks' gestation with dyslipidemia 10-14 years postpartum. RESULTS: Among 4,693 women, 14.3% had GDM. At follow-up, mean (SD) age was 41.7 (5.7) years, 32.3% had total cholesterol (TC) ≥ 5.17, 27.2% had HDL cholesterol < 1.29, 22.4% had LDL cholesterol (LDL-C) ≥ 3.36, 10.9% had triglycerides ≥ 1.69 mmol/L, and 2.9% had type 2 diabetes. After covariate adjustment, pregnancy glycemic measures were associated with all follow-up dyslipidemias. After additional adjustment for pregnancy lipids, GDM remained associated with TC ≥ 5.17 mmol/L (odds ratio [95% CI], 1.63 [1.22-2.18]) and LDL-C ≥ 3.36 mmol/L (1.63 [1.20-2.22]), even in the absence of type 2 diabetes development (1.55 [1.15-2.10] and 1.56 [1.13-2.16], respectively). Continuous glycemic measures in pregnancy were significantly associated with all follow-up dyslipidemias, independent of pregnancy lipids and type 2 diabetes. CONCLUSIONS: Pregnancy glycemia was associated with dyslipidemia 10-14 years later, independent of pregnancy lipid levels and in the absence of type 2 diabetes development. Lipid screening after GDM deserves special consideration.
Authors: G Di Cianni; C Lencioni; L Volpe; A Ghio; I Cuccuru; G Pellegrini; L Benzi; R Miccoli; S Del Prato Journal: Diabetes Metab Res Rev Date: 2007-02 Impact factor: 4.876
Authors: Michael G Nanna; Tracy Y Wang; Qun Xiang; Anne C Goldberg; Jennifer G Robinson; Veronique L Roger; Salim S Virani; Peter W F Wilson; Michael J Louie; Andrew Koren; Zhuokai Li; Eric D Peterson; Ann Marie Navar Journal: Circ Cardiovasc Qual Outcomes Date: 2019-08-16
Authors: William L Lowe; Denise M Scholtens; Lynn P Lowe; Alan Kuang; Michael Nodzenski; Octavious Talbot; Patrick M Catalano; Barbara Linder; Wendy J Brickman; Peter Clayton; Chaicharn Deerochanawong; Jill Hamilton; Jami L Josefson; Michele Lashley; Jean M Lawrence; Yael Lebenthal; Ronald Ma; Michael Maresh; David McCance; Wing Hung Tam; David A Sacks; Alan R Dyer; Boyd E Metzger Journal: JAMA Date: 2018-09-11 Impact factor: 56.272