| Literature DB >> 35192844 |
Manuela G Neuman1, Helmut K Seitz2, Pamela L Tuma3, Natalia A Osna4, Carol A Casey4, Kusum K Kharbanda4, Lawrence B Cohen5, Steve D H Malnick6, Raghabendra Adhikari3, Ramyajit Mitra3, Raghubendra Singh Dagur4, Murali Ganesan4, Chava Srinivas4, Arumugam Madan Kumar4, Moses New-Aaron4, Larisa Poluektova4, Paul G Thomes4, Karuna Rasineni4, Mihai Opris7, Rolf Teschke8.
Abstract
The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.Entities:
Keywords: Acetylation; Alcoholic liver disease; Human immunodeficiency virus; Hyaline Bodies, Lipid and protein traffic; Inflammation; Nonalcoholic liver disease; Nutrition; Tissue culture
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Year: 2022 PMID： 35192844 PMCID： PMC9167794 DOI： 10.1016/j.yexmp.2022.104750
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 4.401