Literature DB >> 35188641

Implementation of In Silico Toxicology Protocols in Leadscope.

Kevin Cross1, Candice Johnson1, Glenn J Myatt2.   

Abstract

In silico toxicology protocols help ensure the results from computational toxicology models are performed and documented in a standardized, consistent, transparent, and accepted manner. In silico toxicology protocols for skin sensitization and genetic toxicology have been previously published and have been implemented within the Leadscope software. The following chapter outlines how such protocols have been deployed in the Leadscope platform including integration with toxicology databases and a battery of computational toxicology models.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Alerts; Computational Toxicology; Genetic Toxicology; In silico; Protocols; QSAR; Skin Sensitization

Mesh：

Year:  2022        PMID： 35188641     DOI： 10.1007/978-1-0716-1960-5_16

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

1.  Adverse Outcome Pathway (AOP) Informed Modeling of Aquatic Toxicology: QSARs, Read-Across, and Interspecies Verification of Modes of Action.

Authors:  Claire M Ellison; Przemyslaw Piechota; Judith C Madden; Steven J Enoch; Mark T D Cronin
Journal:  Environ Sci Technol       Date:  2016-03-10       Impact factor: 9.028

2.  A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data.

Authors:  H J Klimisch; M Andreae; U Tillmann
Journal:  Regul Toxicol Pharmacol       Date:  1997-02       Impact factor: 3.271

3.  Principles for identification of High Potency Category Chemicals for which the Dermal Sensitisation Threshold (DST) approach should not be applied.

Authors:  David W Roberts; Anne Marie Api; Robert J Safford; Jon F Lalko
Journal:  Regul Toxicol Pharmacol       Date:  2015-03-09       Impact factor: 3.271

4.  Comparison of global and mode of action-based models for aquatic toxicity.

Authors:  T M Martin; D M Young; C R Lilavois; M G Barron
Journal:  SAR QSAR Environ Res       Date:  2015       Impact factor: 3.000

5.  Skin sensitization in silico protocol.

Authors:  Candice Johnson; Ernst Ahlberg; Lennart T Anger; Lisa Beilke; Romualdo Benigni; Joel Bercu; Sol Bobst; David Bower; Alessandro Brigo; Sarah Campbell; Mark T D Cronin; Ian Crooks; Kevin P Cross; Tatyana Doktorova; Thomas Exner; David Faulkner; Ian M Fearon; Markus Fehr; Shayne C Gad; Véronique Gervais; Amanda Giddings; Susanne Glowienke; Barry Hardy; Catrin Hasselgren; Jedd Hillegass; Robert Jolly; Eckart Krupp; Liat Lomnitski; Jason Magby; Jordi Mestres; Lawrence Milchak; Scott Miller; Wolfgang Muster; Louise Neilson; Rahul Parakhia; Alexis Parenty; Patricia Parris; Alexandre Paulino; Ana Theresa Paulino; David W Roberts; Harald Schlecker; Reinhard Stidl; Diana Suarez-Rodrigez; David T Szabo; Raymond R Tice; Daniel Urbisch; Anna Vuorinen; Brian Wall; Thibaud Weiler; Angela T White; Jessica Whritenour; Joerg Wichard; David Woolley; Craig Zwickl; Glenn J Myatt
Journal:  Regul Toxicol Pharmacol       Date:  2020-07-01       Impact factor: 3.271

6.  In silico toxicology protocols.

Authors:  Glenn J Myatt; Ernst Ahlberg; Yumi Akahori; David Allen; Alexander Amberg; Lennart T Anger; Aynur Aptula; Scott Auerbach; Lisa Beilke; Phillip Bellion; Romualdo Benigni; Joel Bercu; Ewan D Booth; Dave Bower; Alessandro Brigo; Natalie Burden; Zoryana Cammerer; Mark T D Cronin; Kevin P Cross; Laura Custer; Magdalena Dettwiler; Krista Dobo; Kevin A Ford; Marie C Fortin; Samantha E Gad-McDonald; Nichola Gellatly; Véronique Gervais; Kyle P Glover; Susanne Glowienke; Jacky Van Gompel; Steve Gutsell; Barry Hardy; James S Harvey; Jedd Hillegass; Masamitsu Honma; Jui-Hua Hsieh; Chia-Wen Hsu; Kathy Hughes; Candice Johnson; Robert Jolly; David Jones; Ray Kemper; Michelle O Kenyon; Marlene T Kim; Naomi L Kruhlak; Sunil A Kulkarni; Klaus Kümmerer; Penny Leavitt; Bernhard Majer; Scott Masten; Scott Miller; Janet Moser; Moiz Mumtaz; Wolfgang Muster; Louise Neilson; Tudor I Oprea; Grace Patlewicz; Alexandre Paulino; Elena Lo Piparo; Mark Powley; Donald P Quigley; M Vijayaraj Reddy; Andrea-Nicole Richarz; Patricia Ruiz; Benoit Schilter; Rositsa Serafimova; Wendy Simpson; Lidiya Stavitskaya; Reinhard Stidl; Diana Suarez-Rodriguez; David T Szabo; Andrew Teasdale; Alejandra Trejo-Martin; Jean-Pierre Valentin; Anna Vuorinen; Brian A Wall; Pete Watts; Angela T White; Joerg Wichard; Kristine L Witt; Adam Woolley; David Woolley; Craig Zwickl; Catrin Hasselgren
Journal:  Regul Toxicol Pharmacol       Date:  2018-04-17       Impact factor: 3.271

7.  Genetic toxicology in silico protocol.

Authors:  Catrin Hasselgren; Ernst Ahlberg; Yumi Akahori; Alexander Amberg; Lennart T Anger; Franck Atienzar; Scott Auerbach; Lisa Beilke; Phillip Bellion; Romualdo Benigni; Joel Bercu; Ewan D Booth; Dave Bower; Alessandro Brigo; Zoryana Cammerer; Mark T D Cronin; Ian Crooks; Kevin P Cross; Laura Custer; Krista Dobo; Tatyana Doktorova; David Faulkner; Kevin A Ford; Marie C Fortin; Markus Frericks; Samantha E Gad-McDonald; Nichola Gellatly; Helga Gerets; Véronique Gervais; Susanne Glowienke; Jacky Van Gompel; James S Harvey; Jedd Hillegass; Masamitsu Honma; Jui-Hua Hsieh; Chia-Wen Hsu; Tara S Barton-Maclaren; Candice Johnson; Robert Jolly; David Jones; Ray Kemper; Michelle O Kenyon; Naomi L Kruhlak; Sunil A Kulkarni; Klaus Kümmerer; Penny Leavitt; Scott Masten; Scott Miller; Chandrika Moudgal; Wolfgang Muster; Alexandre Paulino; Elena Lo Piparo; Mark Powley; Donald P Quigley; M Vijayaray Reddy; Andrea-Nicole Richarz; Benoit Schilter; Ronald D Snyder; Lidiya Stavitskaya; Reinhard Stidl; David T Szabo; Andrew Teasdale; Raymond R Tice; Alejandra Trejo-Martin; Anna Vuorinen; Brian A Wall; Pete Watts; Angela T White; Joerg Wichard; Kristine L Witt; Adam Woolley; David Woolley; Craig Zwickl; Glenn J Myatt
Journal:  Regul Toxicol Pharmacol       Date:  2019-06-11       Impact factor: 3.271
  7 in total

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