OBJECTIVES: To study the value of heparin-binding protein (HBP) in the diagnosis of severe infection in children. METHODS: This study was a prospective observational study. The medical data of children who were admitted to the pediatric intensive care unit due to infection from January 2019 to January 2020 were collected. According to the diagnostic criteria for severe sepsis and sepsis, the children were divided into a severe sepsis group with 49 children, a sepsis group with 82 children, and a non-severe infection group with 33 children. The three groups were compared in terms of related biomarkers such as plasma HBP, serum C-reactive protein, serum procalcitonin, and platelet count. The receiver operating characteristic (ROC) curve was plotted to investigate the value of plasma HBP level in the diagnosis of severe infection (including severe sepsis and sepsis). RESULTS: The severe sepsis and sepsis groups had a significantly higher plasma HBP level on admission than the non-severe infection group (P<0.05). Compared with the sepsis and non-severe groups, the severe sepsis group had significantly higher serum levels of C-reactive protein and procalcitonin and a significantly lower platelet count (P<0.05). Plasma HBP level had an area under the ROC curve of 0.590 in determining severe infection, with a sensitivity of 38.0% and a specificity of 82.4% (P<0.05). CONCLUSIONS: There is an increase in plasma HBP level in children with severe infection, and plasma HBP level has a lower sensitivity but a higher specificity in the diagnosis of severe infection and can thus be used as one of the markers for the judgment of severe infection in children.
OBJECTIVES: To study the value of heparin-binding protein (HBP) in the diagnosis of severe infection in children. METHODS: This study was a prospective observational study. The medical data of children who were admitted to the pediatric intensive care unit due to infection from January 2019 to January 2020 were collected. According to the diagnostic criteria for severe sepsis and sepsis, the children were divided into a severe sepsis group with 49 children, a sepsis group with 82 children, and a non-severe infection group with 33 children. The three groups were compared in terms of related biomarkers such as plasma HBP, serum C-reactive protein, serum procalcitonin, and platelet count. The receiver operating characteristic (ROC) curve was plotted to investigate the value of plasma HBP level in the diagnosis of severe infection (including severe sepsis and sepsis). RESULTS: The severe sepsis and sepsis groups had a significantly higher plasma HBP level on admission than the non-severe infection group (P<0.05). Compared with the sepsis and non-severe groups, the severe sepsis group had significantly higher serum levels of C-reactive protein and procalcitonin and a significantly lower platelet count (P<0.05). Plasma HBP level had an area under the ROC curve of 0.590 in determining severe infection, with a sensitivity of 38.0% and a specificity of 82.4% (P<0.05). CONCLUSIONS: There is an increase in plasma HBP level in children with severe infection, and plasma HBP level has a lower sensitivity but a higher specificity in the diagnosis of severe infection and can thus be used as one of the markers for the judgment of severe infection in children.
Entities:
Keywords:
Child; Diagnosis; Heparin-binding protein; Sepsis; Severe infection
Authors: Fredrik Kahn; Jonas Tverring; Lisa Mellhammar; Nils Wetterberg; Anna Bläckberg; Erika Studahl; Niklas Hadorn; Robin Kahn; Susanne Nueesch; Philipp Jent; Meret E Ricklin; John Boyd; Bertil Christensson; Parham Sendi; Per Åkesson; Adam Linder Journal: Shock Date: 2019-12 Impact factor: 3.454
Authors: Florian Gaertner; Zerkah Ahmad; Gerhild Rosenberger; Shuxia Fan; Leo Nicolai; Benjamin Busch; Gökce Yavuz; Manja Luckner; Hellen Ishikawa-Ankerhold; Roman Hennel; Alexandre Benechet; Michael Lorenz; Sue Chandraratne; Irene Schubert; Sebastian Helmer; Bianca Striednig; Konstantin Stark; Marek Janko; Ralph T Böttcher; Admar Verschoor; Catherine Leon; Christian Gachet; Thomas Gudermann; Michael Mederos Y Schnitzler; Zachary Pincus; Matteo Iannacone; Rainer Haas; Gerhard Wanner; Kirsten Lauber; Michael Sixt; Steffen Massberg Journal: Cell Date: 2017-11-30 Impact factor: 41.582
Authors: Corsino Rey; Marta Los Arcos; Andrés Concha; Alberto Medina; Soledad Prieto; Pablo Martinez; Belen Prieto Journal: Intensive Care Med Date: 2007-01-27 Impact factor: 17.440
Authors: Adam Linder; Ryan Arnold; John H Boyd; Marko Zindovic; Igor Zindovic; Anna Lange; Magnus Paulsson; Patrik Nyberg; James A Russell; David Pritchard; Bertil Christensson; Per Åkesson Journal: Crit Care Med Date: 2015-11 Impact factor: 7.598
Authors: Sanna Törnblom; Sara Nisula; Suvi T Vaara; Meri Poukkanen; Sture Andersson; Ville Pettilä; Eero Pesonen Journal: Innate Immun Date: 2021-01-18 Impact factor: 2.680