Xiao-Wei Liu1, Tao Ma1, Wei Liu1, Quan Cai1, Li Wang1, Hong-Wei Song1, Liao Yuan1, Zhi Liu2. 1. Department of Emergency, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. 2. Department of Emergency, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: zhuzhi562@gmail.com.
Abstract
PURPOSE: The identification of infection at its early stage in vulnerable patients is challenging. This study aimed to investigate potential biomarkers to distinguish patients progressing to severe sepsis from those with uncomplicated sepsis. MATERIALS AND METHODS: Serum samples were collected from sepsis patients admitted to the emergency department. The mRNA and protein levels of angiopoietin-2 (Ang-2), interleukin-10 (IL-10), heparin-binding protein (HBP), procalcitonin (PCT), adrenomedullin (ADM), and interleukin-6 (IL-6) were evaluated. RESULTS: Compared to those of healthy individuals (n = 47), mRNA levels of ANG2, IL10, HBP, PCT, and ADM were increased in patients who eventually developed sepsis. ANG2 was the only gene whose expression was significantly increased in patients developing severe sepsis than in those with uncomplicated sepsis. Serum levels of Ang-2, IL-10, HBP, PCT, and IL-6 were also increased in sepsis patients, but only Ang-2, HBP, and PCT were elevated in the serum of patients developing severe septic shock than in those with uncomplicated sepsis. Serum levels of Ang-2, HBP, and PCT were closely associated with the sequential organ failure assessment (SOFA) score of the patients. CONCLUSIONS: These findings indicated that sustained elevation of Ang-2, HBP, and PCT were associated with severe infection in critically ill patients.
PURPOSE: The identification of infection at its early stage in vulnerable patients is challenging. This study aimed to investigate potential biomarkers to distinguish patients progressing to severe sepsis from those with uncomplicated sepsis. MATERIALS AND METHODS: Serum samples were collected from sepsispatients admitted to the emergency department. The mRNA and protein levels of angiopoietin-2 (Ang-2), interleukin-10 (IL-10), heparin-binding protein (HBP), procalcitonin (PCT), adrenomedullin (ADM), and interleukin-6 (IL-6) were evaluated. RESULTS: Compared to those of healthy individuals (n = 47), mRNA levels of ANG2, IL10, HBP, PCT, and ADM were increased in patients who eventually developed sepsis. ANG2 was the only gene whose expression was significantly increased in patients developing severe sepsis than in those with uncomplicated sepsis. Serum levels of Ang-2, IL-10, HBP, PCT, and IL-6 were also increased in sepsispatients, but only Ang-2, HBP, and PCT were elevated in the serum of patients developing severe septic shock than in those with uncomplicated sepsis. Serum levels of Ang-2, HBP, and PCT were closely associated with the sequential organ failure assessment (SOFA) score of the patients. CONCLUSIONS: These findings indicated that sustained elevation of Ang-2, HBP, and PCT were associated with severe infection in critically illpatients.
Authors: Abhijit V Lele; Bhunyawee Alunpipatthanachai; Qian Qiu; Crystalyn Clark-Bell; Arraya Watanitanon; Anne Moore; Randall M Chesnut; William Armstead; Monica S Vavilala Journal: Dev Neurosci Date: 2019-09-25 Impact factor: 2.984
Authors: Quan Dong Nguyen; Jeffrey S Heier; Diana V Do; Adam C Mirando; Niranjan B Pandey; Huan Sheng; Theresa Heah Journal: Int J Retina Vitreous Date: 2020-10-13