| Literature DB >> 35177024 |
Jignasa Mehta1, Gabriela Czanner2,3, Simon Harding4,5, David Newsham6, Jude Robinson7.
Abstract
BACKGROUND: Falls are the second leading cause of accidental deaths worldwide mainly in older people. Older people have poor vision and published evidence suggests that it is a risk factor for falls. Less than half of falls clinics assess vision as part of the multi-factorial assessment of older adults at risk of falls despite vision being an essential input for postural stability. The aim of our study was to investigate the relationship between all clinically assessed visual functions and falls amongst older adults in a prospective observational individually age-matched case control study.Entities:
Keywords: Contrast sensitivity; Depth perception; Falls; Social determinants; Vision
Mesh:
Year: 2022 PMID: 35177024 PMCID: PMC8855581 DOI: 10.1186/s12877-022-02784-3
Source DB: PubMed Journal: BMC Geriatr ISSN: 1471-2318 Impact factor: 3.921
Fig. 1Clinical tests used to measure visual function (A-ETDRS Chart, B-Pelli-Robson, C-CSV-1000E, D-Binocular Esterman visual field, E-Frisby stereotest, F-Prism bar to measure prism fusion range
Fig. 2Directed Acyclic Graph demonstrating the causal pathways of a fall using the covariates measured in this study. All causal and biasing paths will be tested in the logistic regression model
Non-visual and visual characteristics of the falls and non-falls participants
| Falls group (N=83) | Non-falls group (N=83) | |||
|---|---|---|---|---|
| Age mean (SD) | 72 years ( 6.5) | 71 years ( 6.5) | ||
| Gender male:female % ratio | 35%:65% | 43%:57% | ||
IDAOPI decile Median [quartiles] | 2* [1, 4] | 6* [2, 8] | ||
| Use of a walking aid % | Always: 16%* Occasionally: 26.5%* | Always: 4%* Occasionally: 12%* | ||
| FES-I score median [quartiles] | 31* [21,45] | 18* [17,22] | ||
TUTG secs median [quartiles] | 10* [7.25,13] | 7* [6,8] | ||
| Hearing impairment N(%) | 32 (38.6%)* | 11 (13.3%)* | ||
| Number of pre-specified co-morbidities median [quartiles] | 2 [1,2]* | 1 [1,2]* | ||
| Taking more than 4 medications N(%) | 52 (62.7%)* | 28 (33.7%)* | ||
Socialise out of the home no. of days median [quartiles] | 5* [3,6] | 6 [5,7] | ||
RAPA median [quartiles] | 4 [3,6]* | 6 [4,6]* | ||
EQ-5D VAS score mean (SD) | 53 (21)* | 84 (15.4)* | ||
Better eye VA- 6m (mean±SD) | 0.16 ±0.23* | 0.07± 0.14* | ||
Better eye VA- 1/3m (mean±SD) | 0.25±0.45* | 0.14±0.16* | ||
Pelli Robson contrast sensitivity (log units) Both eyes- median [quartiles] | 1.65* [1.35, 1.80] | 1.65* [1.35, 1.80] | ||
CSV-1000E (log units) 3cpd Both eyes median [quartiles] | 1.63* [1.49, 1.78] | 1.63* [1.56, 1.78] | ||
CSV-1000E (log units) 6cpd Both eyes median [quartiles] | 1.70* [1.38, 1.84] | 1.84* [1.7, 1.99] | ||
CSV-1000E (log units) 12cpd Both eyes median [quartiles] | 1.08* [0.61, 1.40] | 1.40* [1.25, 1.54] | ||
CSV-1000E (log units) 18cpd Both eyes median [quartiles] | 0.64* [0.17, 0.81] | 0.96* [0.47, 1.10] | ||
Near prism fusion range median prism dioptres [quartiles] | 20 [12, 30] | 12 [8, 14] | 30 [14, 35] | 14 [10, 16] |
Distance prism fusion range median prism dioptres [quartiles] | 12* [8, 20] | 6 [4, 6] | 20* [12,25] | 6 [4, 8] |
Stereoacuity (Frisby) (seconds of arc) | 85* [40, 170] | 55* [30, 85] | ||
Binocular Esterman visual field “Fail”- 4 or more adjoining points missed N (%) | 14 (17%) | 10 (12%) | ||
* p <0.05, Univariate analysis
Model 1- multivariable model of significant non-visual risk factors, Model 2- multivariable logistic regression of visual risk factors. Model 3-combined multivariable regression model of significant non-visual and visual function variables as covariates from Models 1& 2( p < 0.05)
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| -0.29 | 0.07 | 0.75 | 0.66-0.86 | <0.001 |
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| 1.26 | 0.43 | 3.51 | 1.50-8.22 | 0.004 |
| -0.23 | 0.12 | 0.78 | 0.63-0.99 | 0.04 |
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| -0.41 | 0.14 | 0.66 | 0.51-0.87 | 0.003 |
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| -2.81 | 0.66 | 0.06 | 0.02-0.22 | <0.001 |
| 0.90 | 0.45 | 2.47 | 1.02-5.98 | 0.045 |
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| -0.30 | 0.07 | 0.74 | 0.64-0.86 | <0.001 |
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| 1.24 | 0.46 | 3.44 | 1.39-8.54 | 0.008 |
| -0.29 | 0.11 | 0.75 | 0.60-0.93 | 0.01 |
| -2.23 | 0.76 | 0.11 | 0.02-0.48 | 0.003 |
| 1.23 | 0.53 | 3.4 | 1.20-9.69 | 0.02 |
Multivariable logistic regression model of significant risk factors. Forward selection procedure selected from these covariates: reduced visual function, income affecting deprivation in older people, no. of prespecified comorbidities, taking 4 or more medications and hearing impairment
| Variable |
| se( | Odds ratio | 95% CI | p-value |
|---|---|---|---|---|---|
| -0.25 | 0.06 | 0.78 | 0.69-0.88 | <0.001 |
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| 1.16 | 0.43 | 3.18 | 1.36-7.40 | 0.007 |
| 1.25 | 0.39 | 3.49 | 1.64-7.45 | 0.001 |