Fabian Frost1, Frank U Weiss2, Markus M Lerch3. 1. Klinik und Poliklinik für Innere Medizin A, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Deutschland. fabian.frost@med.uni-greifswald.de. 2. Klinik und Poliklinik für Innere Medizin A, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Deutschland. frankulrich.weiss@med.uni-greifswald.de. 3. Ärztliches Direktorat, LMU Klinikum München, Marchioninistr. 15, 81377, München, Deutschland. markus.lerch@med.uni-muenchen.de.
Abstract
BACKGROUND: The human body is inhabited by diverse microorganisms. Together, this so-called microbiome exerts important metabolic functions and contributes to the maintenance of health. At the same time, shifts in the microbiome composition may lead to disease. OBJECTIVES: Review of the current literature about the role of the microbiome in diseases of the pancreas. MATERIALS AND METHODS: Literature search in PubMed and Embase. RESULTS: The exocrine pancreas is a major factor determining the composition and stability of the intestinal microbiome even in healthy people without pancreatic disease. Inflammatory diseases of the pancreas such as acute or chronic pancreatitis lead to reduced microbial diversity, loss of gut barrier stabilizing bacteria and an increase in facultative pathogens like Escherichia or Enterococcus. Even pancreatic cancer tissue harbours microbiota and mice models have shown that the growth of pancreatic cancer can be inhibited by microbiota ablation. CONCLUSIONS: Inflammatory diseases of the pancreas lead to gut microbiome dysbiosis and tumor microbiota probably play a role in the development of pancreatic cancer. Until now, however, there is no proof that therapeutic microbiota modulation in individuals with pancreatic disease can improve mortality or quality of life. At this point, the analysis of the microbiome in pancreatic disease should only be performed in scientific studies.
BACKGROUND: The human body is inhabited by diverse microorganisms. Together, this so-called microbiome exerts important metabolic functions and contributes to the maintenance of health. At the same time, shifts in the microbiome composition may lead to disease. OBJECTIVES: Review of the current literature about the role of the microbiome in diseases of the pancreas. MATERIALS AND METHODS: Literature search in PubMed and Embase. RESULTS: The exocrine pancreas is a major factor determining the composition and stability of the intestinal microbiome even in healthy people without pancreatic disease. Inflammatory diseases of the pancreas such as acute or chronic pancreatitis lead to reduced microbial diversity, loss of gut barrier stabilizing bacteria and an increase in facultative pathogens like Escherichia or Enterococcus. Even pancreatic cancer tissue harbours microbiota and mice models have shown that the growth of pancreatic cancer can be inhibited by microbiota ablation. CONCLUSIONS: Inflammatory diseases of the pancreas lead to gut microbiome dysbiosis and tumor microbiota probably play a role in the development of pancreatic cancer. Until now, however, there is no proof that therapeutic microbiota modulation in individuals with pancreatic disease can improve mortality or quality of life. At this point, the analysis of the microbiome in pancreatic disease should only be performed in scientific studies.
Authors: Fabian Frost; Tim Kacprowski; Malte Rühlemann; Robin Bülow; Jens-Peter Kühn; Andre Franke; Femke-Anouska Heinsen; Maik Pietzner; Matthias Nauck; Uwe Völker; Henry Völzke; Ali A Aghdassi; Matthias Sendler; Julia Mayerle; Frank U Weiss; Georg Homuth; Markus M Lerch Journal: Gastroenterology Date: 2018-11-02 Impact factor: 22.682
Authors: Matthias Sendler; Cindy van den Brandt; Juliane Glaubitz; Anika Wilden; Janine Golchert; Frank Ulrich Weiss; Georg Homuth; Laura L De Freitas Chama; Neha Mishra; Ujjwal Mukund Mahajan; Lukas Bossaller; Uwe Völker; Barbara M Bröker; Julia Mayerle; Markus M Lerch Journal: Gastroenterology Date: 2019-10-05 Impact factor: 22.682
Authors: Maik Pietzner; Kathrin Budde; Malte Rühlemann; Henry Völzke; Georg Homuth; Frank U Weiss; Markus M Lerch; Fabian Frost Journal: J Clin Endocrinol Metab Date: 2021-04-23 Impact factor: 5.958
Authors: Fabian Frost; Tim Kacprowski; Malte Rühlemann; Maik Pietzner; Corinna Bang; Andre Franke; Matthias Nauck; Uwe Völker; Henry Völzke; Marcus Dörr; Jan Baumbach; Matthias Sendler; Christian Schulz; Julia Mayerle; Frank U Weiss; Georg Homuth; Markus M Lerch Journal: Gut Date: 2020-11-09 Impact factor: 23.059
Authors: Fabian Frost; Tim Kacprowski; Malte Rühlemann; Stefan Weiss; Corinna Bang; Andre Franke; Maik Pietzner; Ali A Aghdassi; Matthias Sendler; Uwe Völker; Henry Völzke; Julia Mayerle; Frank U Weiss; Georg Homuth; Markus M Lerch Journal: Sci Rep Date: 2021-03-23 Impact factor: 4.379