Yoko Shigemoto1,2, Hiroshi Matsuda3,4,5, Yukio Kimura1, Emiko Chiba1, Masahiro Ohnishi1, Moto Nakaya1, Norihide Maikusa1, Masayo Ogawa1, Yohei Mukai6, Yuji Takahashi6, Kazuya Sako7, Hiroshi Toyama8, Yoshitaka Inui8, Yasuyuki Taki9, Hiroshi Nagayama10, Kenjiro Ono11,12, Atsushi Kono13, Kenji Sekiguchi14, Shigeki Hirano15, Noriko Sato1. 1. Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan. 2. Drug Discovery and Cyclotron Research Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, 963-8052, Japan. 3. Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan. hiroshi.matsuda@mt.strins.or.jp. 4. Drug Discovery and Cyclotron Research Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, 963-8052, Japan. hiroshi.matsuda@mt.strins.or.jp. 5. Southern TOHOKU Research Institute for Neuroscience, Shin-Otemachi Building 6F (621), 2-2-1, Otemachi, Chiyoda-ku, Tokyo, 199-0004, Japan. hiroshi.matsuda@mt.strins.or.jp. 6. Department of Neurology, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan. 7. Department of Neurology, Nakamura Memorial Hospital, Sapporo, Japan. 8. Department of Radiology, Fujita Health University, Toyoake, Japan. 9. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 10. Department of Neurology, Graduate School of Medicine, Nippon Medical School Bunkyo-Ku, Tokyo, Japan. 11. Division of Neurology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan. 12. Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. 13. Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. 14. Division of Neurology, Kobe University Graduate School of Medicine, Kobe, Japan. 15. Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Abstract
OBJECTIVE: Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [(123)I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults. METHODS: We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject's striatum and then converted the [123I] FP-CIT SPECT images to quantitative SBRs images. To investigate the effects of age and gender effects on striatal DaT binding, we performed a voxel-based analysis using statistical parametric mapping. Gender differences were also compared between young to middle-aged subjects and elderly subjects (age threshold: 60 years). RESULTS: When all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding. CONCLUSION: Our findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.
OBJECTIVE: Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [(123)I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults. METHODS: We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject's striatum and then converted the [123I] FP-CIT SPECT images to quantitative SBRs images. To investigate the effects of age and gender effects on striatal DaT binding, we performed a voxel-based analysis using statistical parametric mapping. Gender differences were also compared between young to middle-aged subjects and elderly subjects (age threshold: 60 years). RESULTS: When all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding. CONCLUSION: Our findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.
Authors: Walter Koch; Oliver Pogarell; Gabriele Pöpperl; Julia Hornung; Christine Hamann; Franz-Josef Gildehaus; Klaus Seelos; Dewi Lewis; Antonella Favit; Klaus Tatsch Journal: J Nucl Med Date: 2007-01 Impact factor: 10.057
Authors: Susan E Best; Philip M Sarrel; Robert T Malison; Marc Laruelle; Sami S Zoghbi; Ronald M Baldwin; John P Seibyl; Robert B Innis; Christopher H van Dyck Journal: Psychopharmacology (Berl) Date: 2005-11-09 Impact factor: 4.530
Authors: Christopher H van Dyck; John P Seibyl; Robert T Malison; Marc Laruelle; Sami S Zoghbi; Ronald M Baldwin; Robert B Innis Journal: Am J Geriatr Psychiatry Date: 2002 Jan-Feb Impact factor: 4.105
Authors: Andrea Varrone; John C Dickson; Livia Tossici-Bolt; Terez Sera; Susanne Asenbaum; Jan Booij; Ozlem L Kapucu; Andreas Kluge; Gitte M Knudsen; Pierre Malick Koulibaly; Flavio Nobili; Marco Pagani; Osama Sabri; Thierry Vander Borght; Koen Van Laere; Klaus Tatsch Journal: Eur J Nucl Med Mol Imaging Date: 2012-11-16 Impact factor: 9.236
Authors: Seunghyeon Shin; Hyun-Yeol Nam; Myung Jun Lee; Kyoungjune Pak; Keunyoung Kim; In Joo Kim Journal: Ann Nucl Med Date: 2020-10-14 Impact factor: 2.668