Zarife Kuloglu1, Funda Çetin2, Nafiye Urgancı3, Zerrin Önal4, Sinan Sarı5, Hasan Yüksekkaya6, Gönül Çaltepe7, Günsel Kutluk4, Ebru Dumlupinar8. 1. School of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Ankara University, Ankara, Turkey. zarifekuloglu@yahoo.com. 2. Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Ege University, İzmir, Turkey. 3. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey. 4. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Bakırköy Dr. Sadi Konuk Research and Training Center, İstanbul, Turkey. 5. Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Gazi University University, Ankara, Turkey. 6. Meram Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Necmettin Erbakan University, Konya, Turkey. 7. Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Ondokuz Mayıs University, Samsun, Turkey. 8. School of Medicine, Department of Biostatistics, Ankara University , Ankara, Turkey.
Abstract
BACKGROUND/ OBJECTIVES: We analyzed the nationwide pediatric inflammatory bowel disease (PIBD) registry (1998-2016), to evaluate the nutritional status at the time of diagnosis. SUBJECTS/ METHODS: Nine types of nutritional status by the combination of weight-for-length (<2 years)/body mass index (>2 years) and length/height-for-age with three categories (<-2, -2 to 2, and >2 SD) were described. Malnutrition was defined by WHO criteria. Univariate and multivariate regression analysis was used to identify risk factors for malnutrition. RESULTS: In total, 824 IBD patients (498 Ulcerative colitis (UC); 289 Crohn's Disease (CD); 37 Indeterminate Colitis (IC); 412 male; the median age 12.5 years) were eligible. The prevalence of eutrophy, wasting/thinness, stunting, overweight, tall stature, concurrent wasting/thinness and stunting, tall stature with overweight, tall stature with wasting/thinness, and short stature with overweight were 67.4%, 14.9%, 6.6%, 3.1%, 3.2%, 3.3%, 1.1%, 0.4%, and 0.1%, respectively. The prevalence of malnutrition was 32.7%, indicating a higher prevalence in CD (p < 0.001). Incidence of overweight was less common in the CD than UC and IC (p < 0.001). Multivariate analysis revealed that age of onset (>10 years), prepubertal stage, severe disease activity, perianal involvement, and high C reactive protein level were independently associated with malnutrition in pediatric IBD. CONCLUSION: We showed the frequency of nutritional impairment in PIBD. The percentage of overweight subjects was lower than the other studies. The age of onset, disease activity, CRP level, perianal involvement, and pubertal stage were associated with a higher risk for developing malnutrition. Our results also confirmed that CD patients are particularly vulnerable to nutritional impairment. CLINICAL TRIAL NUMBER: ClinicalTrials.gov Identifier: NCT04457518.
BACKGROUND/ OBJECTIVES: We analyzed the nationwide pediatric inflammatory bowel disease (PIBD) registry (1998-2016), to evaluate the nutritional status at the time of diagnosis. SUBJECTS/ METHODS: Nine types of nutritional status by the combination of weight-for-length (<2 years)/body mass index (>2 years) and length/height-for-age with three categories (<-2, -2 to 2, and >2 SD) were described. Malnutrition was defined by WHO criteria. Univariate and multivariate regression analysis was used to identify risk factors for malnutrition. RESULTS: In total, 824 IBD patients (498 Ulcerative colitis (UC); 289 Crohn's Disease (CD); 37 Indeterminate Colitis (IC); 412 male; the median age 12.5 years) were eligible. The prevalence of eutrophy, wasting/thinness, stunting, overweight, tall stature, concurrent wasting/thinness and stunting, tall stature with overweight, tall stature with wasting/thinness, and short stature with overweight were 67.4%, 14.9%, 6.6%, 3.1%, 3.2%, 3.3%, 1.1%, 0.4%, and 0.1%, respectively. The prevalence of malnutrition was 32.7%, indicating a higher prevalence in CD (p < 0.001). Incidence of overweight was less common in the CD than UC and IC (p < 0.001). Multivariate analysis revealed that age of onset (>10 years), prepubertal stage, severe disease activity, perianal involvement, and high C reactive protein level were independently associated with malnutrition in pediatric IBD. CONCLUSION: We showed the frequency of nutritional impairment in PIBD. The percentage of overweight subjects was lower than the other studies. The age of onset, disease activity, CRP level, perianal involvement, and pubertal stage were associated with a higher risk for developing malnutrition. Our results also confirmed that CD patients are particularly vulnerable to nutritional impairment. CLINICAL TRIAL NUMBER: ClinicalTrials.gov Identifier: NCT04457518.
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