Dan Turner1, Frank M Ruemmele2, Esther Orlanski-Meyer1, Anne M Griffiths3, Javier Martin de Carpi4, Jiri Bronsky5, Gabor Veres6, Marina Aloi7, Caterina Strisciuglio8, Christian P Braegger9, Amit Assa10, Claudio Romano11, Séamus Hussey12, Michael Stanton13, Mikko Pakarinen14, Lissy de Ridder15, Konstantinos Katsanos16, Nick Croft17, Victor Navas-López18, David C Wilson19, Sally Lawrence20, Richard K Russell21. 1. Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel. 2. Université Paris Descartes, Sorbonne Paris Cité, APHP, Hôpital Necker Enfants Malades, Paris, France. 3. The Hospital for Sick Children, University of Toronto, Toronto, Canada. 4. Hospital Sant Joan de Déu, Barcelona, Spain. 5. Department of Paediatrics, University Hospital Motol, Prague, Czech Republic. 6. 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. 7. Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy. 8. Department of Woman, Child and General and Specialistic Surgery, University of Campania "Luigi Vanvitelli," Napoli, Italy. 9. University Children's Hospital, Zurich, Switzerland. 10. Schneider Children's Hospital, Petach Tikva, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 11. Pediatric Department, University of Messina, Messina, Italy. 12. National Children's Research Centre, Royal College of Surgeons of Ireland and University College Dublin, Dublin, Ireland. 13. Southampton Children's Hospital, Southampton, UK. 14. Helsinki University Children's Hospital, Department of Pediatric Surgery, Helsinki, Finland. 15. Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. 16. School of Medical Sciences Ioannina, University of Ioannina, Ioannina, Greece. 17. Barts and the London School of Medicine, Queen Mary University of London, London, UK. 18. Pediatric Gastroenterology and Nutrition Unit. Hospital Materno, IBIMA, Málaga, Spain. 19. Child Life and Health, University of Edinburgh, Edinburgh, UK. 20. BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada. 21. The Royal Hospital for Children, Glasgow, UK.
Abstract
BACKGROUND: The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of pediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). An extensive literature search with subsequent evidence appraisal using robust methodology was performed before 2 face-to-face meetings. All 40 included recommendations and 86 practice points were endorsed by 43 experts in Paediatric IBD with at least an 88% consensus rate. RESULTS: These guidelines discuss how to optimize the use of mesalamine (including topical), systemic and locally active steroids, thiopurines and, for more severe disease, biologics. The use of other emerging therapies and the role of surgery are also covered. Algorithms are provided to aid therapeutic decision-making based on clinical assessment and the Paediatric UC Activity Index (PUCAI). Advice on contemporary therapeutic targets incorporating the use of calprotectin and the role of therapeutic drug monitoring are presented, as well as other management considerations around pouchitis, extraintestinal manifestations, nutrition, growth, psychology, and transition. A brief section on disease classification using the PIBD-classes criteria and IBD-unclassified is also part of these guidelines. CONCLUSIONS: These guidelines provide a guide to clinicians managing children with UC and IBD-unclassified management to provide modern management strategies while maintaining vigilance around appropriate outcomes and safety issues.
BACKGROUND: The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of pediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). An extensive literature search with subsequent evidence appraisal using robust methodology was performed before 2 face-to-face meetings. All 40 included recommendations and 86 practice points were endorsed by 43 experts in Paediatric IBD with at least an 88% consensus rate. RESULTS: These guidelines discuss how to optimize the use of mesalamine (including topical), systemic and locally active steroids, thiopurines and, for more severe disease, biologics. The use of other emerging therapies and the role of surgery are also covered. Algorithms are provided to aid therapeutic decision-making based on clinical assessment and the Paediatric UC Activity Index (PUCAI). Advice on contemporary therapeutic targets incorporating the use of calprotectin and the role of therapeutic drug monitoring are presented, as well as other management considerations around pouchitis, extraintestinal manifestations, nutrition, growth, psychology, and transition. A brief section on disease classification using the PIBD-classes criteria and IBD-unclassified is also part of these guidelines. CONCLUSIONS: These guidelines provide a guide to clinicians managing children with UC and IBD-unclassified management to provide modern management strategies while maintaining vigilance around appropriate outcomes and safety issues.
Authors: Jeffrey S Hyams; Sonia Davis Thomas; Nathan Gotman; Yael Haberman; Rebekah Karns; Melanie Schirmer; Angela Mo; David R Mack; Brendan Boyle; Anne M Griffiths; Neal S LeLeiko; Cary G Sauer; David J Keljo; James Markowitz; Susan S Baker; Joel Rosh; Robert N Baldassano; Ashish Patel; Marian Pfefferkorn; Anthony Otley; Melvin Heyman; Joshua Noe; Maria Oliva-Hemker; Paul A Rufo; Jennifer Strople; David Ziring; Stephen L Guthery; Boris Sudel; Keith Benkov; Prateek Wali; Dedrick Moulton; Jonathan Evans; Michael D Kappelman; M Alison Marquis; Francisco A Sylvester; Margaret H Collins; Suresh Venkateswaran; Marla Dubinsky; Vin Tangpricha; Krista L Spada; Bradley Saul; Jessie Wang; Jose Serrano; Kevin Hommel; Urko M Marigorta; Greg Gibson; Ramnik J Xavier; Subra Kugathasan; Thomas Walters; Lee A Denson Journal: Lancet Date: 2019-03-29 Impact factor: 79.321
Authors: Marta Velasco Rodríguez-Belvís; Javier Francisco Viada Bris; Carmen Plata Fernández; Alberto García-Salido; Julia Asensio Antón; Gloria Domínguez Ortega; Rosa Ana Muñoz Codoceo Journal: Paediatr Child Health Date: 2019-06-17 Impact factor: 2.253