Literature DB >> 35167095

Activation of UCP1-Independent Ca2+ Cycling Thermogenesis by Wireless Optogenetics.

Kenji Ikeda1, Kazuki Tajima2, Yuji Tanabe3, Ada S Y Poon4,5, Shingo Kajimura6.   

Abstract

The identification of non-canonical UCP1-independent thermogenic mechanisms offers new opportunities to target such pathways to improve metabolic health. Based on our recent studies on Ca2+ futile cycling thermogenesis in beige fat, we applied the newly developed implantable wireless optogenetic system to activate Ca2+ cycling in an adipocyte-specific manner without external stimuli, i.e., fat-specific cold mimetics. Here, we describe the detailed methodology and application to the prevention of obesity.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Beige fat; Ca2+ cycling thermogenesis; Obesity; Optogenetics; SERCA2

Mesh：

Substances：

Year:  2022        PMID： 35167095      PMCID： PMC9087983          DOI： 10.1007/978-1-0716-2087-8_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  12 in total

1.  Uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase. Regulation by ADP.

Authors:  L de Meis
Journal:  J Biol Chem       Date:  2001-05-07       Impact factor: 5.157

2.  PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

Authors:  Haruya Ohno; Kosaku Shinoda; Bruce M Spiegelman; Shingo Kajimura
Journal:  Cell Metab       Date:  2012-03-07       Impact factor: 27.287

3.  Automated reactive accelerated aging for rapid in vitro evaluation of neural implant performance.

Authors:  Matthew G Street; Cristin G Welle; Pavel A Takmakov
Journal:  Rev Sci Instrum       Date:  2018-09       Impact factor: 1.523

4.  Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.

Authors:  Yutaka Hasegawa; Kenji Ikeda; Yong Chen; Diana L Alba; Daniel Stifler; Kosaku Shinoda; Takashi Hosono; Pema Maretich; Yangyu Yang; Yasushi Ishigaki; Jingyi Chi; Paul Cohen; Suneil K Koliwad; Shingo Kajimura
Journal:  Cell Metab       Date:  2018-01-09       Impact factor: 27.287

5.  in vitro Reactive-Accelerated-Aging (RAA) Assessment of Tissue-Engineered Electronic Nerve Interfaces (TEENI).

Authors:  Cary A Kuliasha; Jack W Judy
Journal:  Annu Int Conf IEEE Eng Med Biol Soc       Date:  2018-07

6.  The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in piglets.

Authors:  Frida Berg; Ulla Gustafson; Leif Andersson
Journal:  PLoS Genet       Date:  2006-08-18       Impact factor: 5.917

Review 7.  Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade.

Authors:  Alessandro Cannavo; Walter J Koch
Journal:  J Cardiovasc Pharmacol       Date:  2017-02       Impact factor: 3.105

8.  UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.

Authors:  Kenji Ikeda; Qianqian Kang; Takeshi Yoneshiro; Joao Paulo Camporez; Hiroko Maki; Mayu Homma; Kosaku Shinoda; Yong Chen; Xiaodan Lu; Pema Maretich; Kazuki Tajima; Kolapo M Ajuwon; Tomoyoshi Soga; Shingo Kajimura
Journal:  Nat Med       Date:  2017-11-13       Impact factor: 53.440

Review 9.  Metabolic adaptation and maladaptation in adipose tissue.

Authors:  Edward T Chouchani; Shingo Kajimura
Journal:  Nat Metab       Date:  2019-01-21

10.  Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis.

Authors:  Kazuki Tajima; Kenji Ikeda; Yuji Tanabe; Ella A Thomson; Takeshi Yoneshiro; Yasuo Oguri; Marc D Ferro; Ada S Y Poon; Shingo Kajimura
Journal:  Nat Commun       Date:  2020-04-07       Impact factor: 14.919
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