Babak Arjmand1, Mahmood Khodadoost2, Somayeh Jahani Sherafat3, Mostafa Rezaei Tavirani4, Nayebali Ahmadi4, Farshad Okhovatian5, Majid Rezaei Tavirani6. 1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 2. School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Physiotherapy Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract
Introduction: There are many documents about the significant role of low-level laser therapy (LLLT) in different processes such as regenerator medicine and bone formation. The aim of this study is to assess the role of LLLT in blood hemostasis in rats via bioinformatic investigation. Methods: The differentially expressed plasma proteins of treated rats via LLLT from the literature and the added 50 first neighbors were investigated via network analysis to find the critical dysregulated proteins and biological processes by using Cytoscape software, the STRING database, and ClueGO. Results: A scale-free network including 55 nodes was constructed from queried and added first neighbor proteins. Fibrinogen gamma, fibrinogen alpha, and plasminogen were highlighted as the central genes of the analyzed network. Fibrinolysis was determined as the main group of biological processes that were affected by LLLT. Conclusion: Findings indicate that LLLT affects blood hemostasis which is an important point in approving the therapeutic application of LLLT and also in preventing its possible complication.
Introduction: There are many documents about the significant role of low-level laser therapy (LLLT) in different processes such as regenerator medicine and bone formation. The aim of this study is to assess the role of LLLT in blood hemostasis in rats via bioinformatic investigation. Methods: The differentially expressed plasma proteins of treated rats via LLLT from the literature and the added 50 first neighbors were investigated via network analysis to find the critical dysregulated proteins and biological processes by using Cytoscape software, the STRING database, and ClueGO. Results: A scale-free network including 55 nodes was constructed from queried and added first neighbor proteins. Fibrinogen gamma, fibrinogen alpha, and plasminogen were highlighted as the central genes of the analyzed network. Fibrinolysis was determined as the main group of biological processes that were affected by LLLT. Conclusion: Findings indicate that LLLT affects blood hemostasis which is an important point in approving the therapeutic application of LLLT and also in preventing its possible complication.
Authors: M Ashburner; C A Ball; J A Blake; D Botstein; H Butler; J M Cherry; A P Davis; K Dolinski; S S Dwight; J T Eppig; M A Harris; D P Hill; L Issel-Tarver; A Kasarskis; S Lewis; J C Matese; J E Richardson; M Ringwald; G M Rubin; G Sherlock Journal: Nat Genet Date: 2000-05 Impact factor: 38.330
Authors: Jacob Raphael; C David Mazer; Sudhakar Subramani; Andrew Schroeder; Mohamed Abdalla; Renata Ferreira; Philip E Roman; Nichlesh Patel; Ian Welsby; Philip E Greilich; Reed Harvey; Marco Ranucci; Lori B Heller; Christa Boer; Andrew Wilkey; Steven E Hill; Gregory A Nuttall; Raja R Palvadi; Prakash A Patel; Barbara Wilkey; Brantley Gaitan; Shanna S Hill; Jenny Kwak; John Klick; Bruce A Bollen; Linda Shore-Lesserson; James Abernathy; Nanette Schwann; W Travis Lau Journal: J Cardiothorac Vasc Anesth Date: 2019-04-19 Impact factor: 2.628