| Literature DB >> 35143205 |
Qing Zhang1, Shuaishuai Wang2, Zhonghua Li1, Yi Lasanajak3, Lei Li2, Xuezheng Song1,3.
Abstract
Glycans are usually fluorescently tagged by reductive amination for analytic tools. However, free reducing glycan regeneration is sometimes important and necessary for further structural or functional studies. Here, we introduce a new method for efficiently removing fluorescent tags from glycoconjugates by a simple treatment with Oxone. This method is proven to be fast and general after being tested on a series of common saccharides and widely used tags. We successfully achieved N-glycopeptide synthesis by using the regenerated glycans.Entities:
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Year: 2022 PMID： 35143205 PMCID： PMC9228866 DOI： 10.1021/acs.joc.1c02709
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.198