Literature DB >> 3513761

Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate.

C S Hii, J Stutchfield, S L Howell.   

Abstract

The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose. Stimulation of secretion of both hormones by 1 microM-PMA persisted in the absence of external Ca2+, and could be abolished by incubating the islets at 4 degrees C. These findings suggest a role of protein kinase C in the alpha-cell (and beta-cell) secretory mechanism.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3513761      PMCID： PMC1153019          DOI： 10.1042/bj2330287

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors:  W M HUNTER; F C GREENWOOD
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

2.  Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays.

Authors:  B Desbuquois; G D Aurbach
Journal:  J Clin Endocrinol Metab       Date:  1971-11       Impact factor: 5.958

3.  Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets.

Authors:  P Thams; K Capito; C J Hedeskov
Journal:  Biochem J       Date:  1984-07-01       Impact factor: 3.857

4.  Ventral and dorsal areas of rat pancreas: islet hormone content and secretion.

Authors:  E R Trimble; A E Renold
Journal:  Am J Physiol       Date:  1981-04

Review 5.  Protein phosphorylation in the pancreatic B-cell.

Authors:  D E Harrison; S J Ashcroft; M R Christie; J M Lord
Journal:  Experientia       Date:  1984-10-15

6.  Phorbol diester receptor copurifies with protein kinase C.

Authors:  J E Niedel; L J Kuhn; G R Vandenbark
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

7.  Tumor promotor 12-O-tetradecanoylphorbol-13-acetate-induced insulin secretion: inhibition by phospholipase A2-and lipoxygenase-inhibitors.

Authors:  S Yamamoto; T Nakadate; T Nakaki; K Ishii; R Kato
Journal:  Biochem Biophys Res Commun       Date:  1982-03-30       Impact factor: 3.575

8.  Calcium-activated, phospholipid-dependent protein kinase in rat pancreas islets of langerhans. Its possible role in glucose-induced insulin release.

Authors:  K Tanigawa; H Kuzuya; H Imura; H Taniguchi; S Baba; Y Takai; Y Nishizuka
Journal:  FEBS Lett       Date:  1982-02-22       Impact factor: 4.124

9.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

10.  Insulin secretion: combined effects of phorbol ester and A23187.

Authors:  W Zawalich; C Brown; H Rasmussen
Journal:  Biochem Biophys Res Commun       Date:  1983-12-16       Impact factor: 3.575
View more
  13 in total

1.  Effect of a hypoglycaemic agent M&B 39890A on glucagon secretion in isolated rat islets of Langerhans.

Authors:  M Tadayyon; I Green; D Cook; J Pratt
Journal:  Diabetologia       Date:  1987-01       Impact factor: 10.122

2.  Phorbol-ester-induced down-regulation of protein kinase C in mouse pancreatic islets. Potentiation of phase 1 and inhibition of phase 2 of glucose-induced insulin secretion.

Authors:  P Thams; K Capito; C J Hedeskov; H Kofod
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

Review 3.  Protein kinase C isoforms in the normal pancreas and in pancreatic disease.

Authors:  Alicia K Fleming; Peter Storz
Journal:  Cell Signal       Date:  2017-08-18       Impact factor: 4.315

4.  Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets.

Authors:  Z Y Gao; G Drews; J C Henquin
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

5.  Ionic dependence of amino-acid transport in the exocrine pancreatic epithelium: calcium dependence of insulin action.

Authors:  P S Norman; G E Mann
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

6.  A re-assessment of the role of protein kinase C in glucose-stimulated insulin secretion.

Authors:  C S Hii; P M Jones; S J Persaud; S L Howell
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

7.  Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

Authors:  Y Z De Marinis; E Zhang; S Amisten; J Taneera; E Renström; P Rorsman; L Eliasson
Journal:  Diabetologia       Date:  2009-12-18       Impact factor: 10.122

8.  Role of protein kinase C and Ca2+ in glucose-induced sensitization/desensitization of insulin secretion.

Authors:  P Thams
Journal:  Experientia       Date:  1991-12-01

9.  Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets.

Authors:  S J Hughes; S J Ashcroft
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

10.  Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.

Authors:  R A Easom; J H Hughes; M Landt; B A Wolf; J Turk; M L McDaniel
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.