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Literature DB >> 6229253

Insulin secretion: combined effects of phorbol ester and A23187.

Abstract

The effect of the ionophore, A23187, and/or the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), on insulin secretion were compared with those of glucose. Glucose induces a biphasic pattern of insulin secretion; A23187 a comparable initial spike but no second phase; and TPA a slowly progressive increase. Combined A23187 and TPA evoke a pattern similar to that induced by glucose. Forskolin enhances both phases of glucose- induced and of TPA-A23187-induced insulin secretion. These results are interpreted in terms of a model of cell activation in which two branches of the calcium messenger system, the calmodulin branch and the C-kinase branch, control, respectively, the initial and sustained phases of insulin secretion.

Entities: Chemical Disease Gene

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Year: 1983 PMID： 6229253 DOI： 10.1016/0006-291x(83)91221-4

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

50 in total

1. Muscarinic activation of Ca2+/calmodulin-dependent protein kinase II in pancreatic islets. Temporal dissociation of kinase activation and insulin secretion.

Authors: E L Babb; J Tarpley; M Landt; R A Easom
Journal: Biochem J Date: 1996-07-01 Impact factor: 3.857

2. Glucose-induced translocation of protein kinase C in rat pancreatic islets.

Authors: S Ganesan; R Calle; K Zawalich; J I Smallwood; W S Zawalich; H Rasmussen
Journal: Proc Natl Acad Sci U S A Date: 1990-12 Impact factor: 11.205

Review 3. The role of phosphoinositides in signal transduction.

Authors: M C Sekar; L E Hokin
Journal: J Membr Biol Date: 1986 Impact factor: 1.843

4. Selective regulation of trypsin gene expression by calcium and by glucose starvation in a rat exocrine pancreas cell line.

Authors: C Stratowa; W J Rutter
Journal: Proc Natl Acad Sci U S A Date: 1986-06 Impact factor: 11.205

5. Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.

Authors: A E Nel; M W Wooten; G E Landreth; P J Goldschmidt-Clermont; H C Stevenson; P J Miller; R M Galbraith
Journal: Biochem J Date: 1986-01-01 Impact factor: 3.857

10. The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation.

Authors: A H Drummond; C A Raeburn
Journal: Biochem J Date: 1984-11-15 Impact factor: 3.857

Insulin secretion: combined effects of phorbol ester and A23187.

1. Muscarinic activation of Ca2+/calmodulin-dependent protein kinase II in pancreatic islets. Temporal dissociation of kinase activation and insulin secretion.

2. Glucose-induced translocation of protein kinase C in rat pancreatic islets.

Review 3. The role of phosphoinositides in signal transduction.

4. Selective regulation of trypsin gene expression by calcium and by glucose starvation in a rat exocrine pancreas cell line.

5. Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.

6. Regulation of protein kinase C by extracellular calcium in bovine parathyroid cells.

Review 7. Inositol trisphosphate and diacylglycerol as second messengers.

8. The effect of monooleoylglycerol on insulin secretion from isolated perifused rat islets.

9. Vacor inhibits insulin release from islets in vitro.

10. The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation.