| Literature DB >> 35132727 |
Kirsty V Biggs1, San Soo Hoo2, Mallikarjun Kodampur2.
Abstract
AIM: Cervical stenosis is traditionally managed by mechanical dilatation under general anesthesia (GA). We aimed to assess the safety, effectiveness, and patient acceptability of dilatation in the outpatient setting under local anesthesia (LA).Entities:
Keywords: anesthesia; cervical intraepithelial neoplasia; colposcopy; local; outpatients; uterine cervical neoplasms
Mesh:
Year: 2022 PMID: 35132727 PMCID: PMC9303640 DOI: 10.1111/jog.15179
Source DB: PubMed Journal: J Obstet Gynaecol Res ISSN: 1341-8076 Impact factor: 1.697
Patient characteristics
| Age | 50 (39, 55) |
|---|---|
| Parity | 2 (0, 3) |
| Contraceptive method | |
| Menopausal | 64 (43) |
| Perimenopausal | 6 (4) |
| POP | 13 (9) |
| Implant | 9 (6) |
| COCP | 8 (5) |
| Mirena IUS | 4 (3) |
| Depo provera | 3 (2) |
| Sterilization | 7 (5) |
| Vasectomy | 3 (2) |
| Condoms | 4 (3) |
| No contraceptive | 27 (18) |
| Previous LLETZ | 118 (79) |
| 1 LLETZ | 87 (59) |
| 2 LLETZ | 27 (18) |
| 3 LLETZ | 4 (3) |
| Previous O/G procedures | 28 (19) |
| Presence of comorbidities | 46 (31) |
Note: All data is displayed as number (%) or median (interquartile range). Previous gynecological procedures: cesarean section (n = 15), sterilization (n = 7), cervical polypectomy (n = 3), endometrial ablation (n = 3), cervical dilatation (n = 2), evacuation of retained products of conception (n = 2), salpingo‐oophorectomy (n = 2), laparotomy (n = 1), dilation and curettage (n = 1), oophorectomy (n = 1), Comorbidities: hypertension (n = 12), cardiac other (n = 5), respiratory (n = 11), diabetes/endocrine (n = 10), musculoskeletal (n = 5), breast cancer (n = 3), gastrointestinal (n = 3), gynecological (n = 2), psychiatric (n = 2), Meniere's disease (n = 1), HIV (n = 1), Di‐George syndrome (n = 1).
Abbreviations: COCP, combined oral contraceptive pill; IUS, intrauterine system; LLETZ, large loop excision of the transformation zone; POP, progestogen only pill.
Cervical stenosis and dilatation
|
| |
|---|---|
| Degree of stenosis | |
| Severe stenosis | 75 (51) |
| Complete stenosis | 63 (43) |
| Not assessed/ missing data | 10 (7) |
| Hematometra | 1 (<1%) |
| Cervical dilatation | |
| Opted for GA without trial of LA (patient choice) | 5/149 (3) |
| Procedure performed successfully under LA | 119/144 (83) |
| Unable to tolerate procedure/examination | 6/144 (4) |
| Failed procedure | 19/144 (13) |
| Hegar dilator used (mm) | 8 (7,8) |
| Patient preferred LA to GA (asked postprocedure) | 128/137 (93) |
| Complications | |
| Vasovagal episode | 1/144 (<1) |
| Infection | 1/144 (<1) |
| Restenosis episodes | 13/119 (11) |
| Restenosis management | |
| Hysterectomy | 8/13 (62) |
| Repeat dilatation under GA | 2/13 (15) |
| Repeat dilatation under LA | 2/13 (15) |
| LLETZ (GA) | 1/13 (8) |
| Management of unsuccessful LA dilatation |
|
| Hysterectomy | 9 (36) |
| Withdrawal from screening | 9 (36) |
| Dilatation under GA | 5 (20) |
| Offered repeat smear only | 1 (4) |
| LLETZ (GA) | 1(4) |
Note: All data is displayed as number (%) or median (interquartile range).
Abbreviations: GA, general anesthetic; LA, local anesthetic; LLETZ, large loop excision of the transformation zone.
Missing data (n = 6).
Univariate analysis
| Factors affecting degree of stenosis | Severe stenosis | Complete stenosis |
|
|---|---|---|---|
| Median date of procedure | 07 July, 2017 | August 18, 2017 | 0.595 |
| Age | 48 (35, 54) | 51 (40, 58) | 0.13 |
| Parity | 2 (0, 3) | 2 (0, 2) | 0.469 |
| Menopausal | 30/74 (41) | 30/63 (48) | 0.487 |
| No. previous LLETZ | 1 (1,1) | 1 (1, 2) | 0.004 |
| Previous O/G procedures | 19/74 (26) | 18/63 (29) | 0.704 |
| Presence medical comorbidities | 19/74 (26) | 22/63 (35) | 0.239 |
| Hegar dilatation achieved | 8 (7, 8) | 7 (0,8) | <0.0001 |
| Restenosis | 7/74 (9) | 5/63 (8) | 0.247 |
| Factors affecting success of procedure | Successful LA Dilatation | Unsuccessful LA Dilatation | |
| Median date of procedure | August 18, 2017 | June 09, 2016 | 0.003 |
| Age | 49 (36, 54) | 53 (47, 61) | 0.045 |
| Parity | 2 (0, 3) | 1 (1, 2) | 0.136 |
| Menopausal | 48/118 (41) | 14/24 (58) | 0.086 |
| No. previous LLETZ | 1 (1, 1) | 1 (1, 2) | 0.415 |
| Previous O/G procedures | 30/118 (25) | 8/24 (33) | 0.425 |
| Presence of medical comorbidities | 35/118 | 8/24 (33) | 0.721 |
Note: All data is displayed as number (%) or median (interquartile range).
Abbreviations: GA, general anesthetic; LA, local anesthetic; LLETZ, large loop excision of the transformation zone; O/G, obstetric or gynecological.
Cytology, follow‐up, histology, and further management
| Predilatation | First postdilatation | |
|---|---|---|
| Cytology result | ||
| Normal | 55 (37) | 70 (47) |
| Normal, HPV positive | 30 (20) | 25 (17) |
| Borderline | 5 (3) | 4 (3) |
| Borderline, HPV positive | 13 (9) | 9 (6) |
| Low grade | 10 (7) | 9 (6) |
| Low grade, HPV positive | 6 (4) | 3 (2) |
| Moderate grade | 1 (<1) | 0 (0) |
| High grade | 1 (<1) | 0 (0) |
| Inadequate sample | 3 (2) | 2 (1) |
| No result | 24 (16) | 26 (18) |
| Follow‐up smear management | ||
| Discharged to GP (Routine) | 48 (32) | |
| Repeat Colp clinic, discharged to GP (Routine) | 22 (15) | |
| Repeat Colp clinic, discharged to GP (annual/ 6mo) | 11 (7) | |
| Repeat Colp clinic, on‐going hospital surveillance | 30 (20) | |
| Repeat Colp clinic, discharged (no further smears) | 4 (3) | |
| Did not attend | 11 (7) | |
| No follow‐up required | 11 (7) | |
| Missing data | 3 (2) | |
| Patients requiring LLETZ | 8 | |
| Adequate colposcopy | 20/48 (42) | |
| Histology | From LLETZ | From Hysterectomy |
| HPV/benign/inflammatory | 7 (78) | 19 (90) |
| Grade 1 ectocervical adenocarcinoma, (FIGO Stage 1A1) | 0 | 1 (5) |
| CIN1 | 2 (22) | 0 |
| CIN3 | 0 | 1 (5) |
Note: All data is displayed as number (%).
Abbreviations: CIN, cervical intraepithelial neoplasia; Colp, colposcopy; FIGO, The International Federation of Gynecology and Obstetrics; GP, general practice; HPV, human papilloma virus; LLETZ, large loop excision of transformation zone.
Reasons for LLETZ after successful cervical dilatation
| Pt | Previous LLETZ | Stenosis | Successful LA dilatation | Preresult | Postresult | Colposcopy | Histology | Comment |
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | Complete | y | Borderline + HPV | Borderline + HPV | Inadequate | HPV/benign/inflammatory | Repeat smear 1 year after LLETZ |
| 2 | 1 | Complete | y | NAD + HPV | NAD + HPV | Inadequate | HPV/benign/inflammatory | Repeat smear in 6 months by GP after LLETZ |
| 3 | 1 | Significant | Required GA | Borderline | Borderline | Inadequate | HPV/benign/inflammatory | Repeat smear in 6 months by GP after LLETZ |
| 4 | 1 | Significant | y | Borderline | Borderline | Inadequate ×2 | HPV/benign/inflammatory | Initial smear successful (3 months), inadequate colp, restenosis on repeat 3mo smear (second LA dilatation), successful smear (3 months), inadequate colp, LLETZ performed, repeat smear in 1 year |
| 5 | 1 | Complete | y | Borderline | NAD + HPV | Inadequate | HPV/benign/inflammatory | Repeat smear in 6 months by GP after LLETZ |
| 6 | 1 | Complete | y | Low grade | Low grade | LLETZ indicated | CIN1 | Repeat smear in 6 months by GP after LLETZ |
| 7 | 0 | Significant | y | Low grade | Low grade | LLETZ indicated | CIN1 | Repeat smear in 1 year by GP after LLETZ |
| 8 | 1 | Significant | y | NAD + HPV | NAD + HPV | LLETZ indicated | CIN3 | Incomplete excision of CIN3, patient had hysterectomy, vault smear in 6 months |
Abbreviations: CIN, cervical intraepithelial neoplasia; Colp, colposcopy; GA, general anesthetic; GP, general practice; HPV, human papilloma virus; LA, local anesthetic; LLETZ, large loop excision of transformation zone; NAD, no abnormality detected.