Derya Öztomurcuk1, Özlem Terzi2, Canan Demirci3, Zeki Kılıçaslan4. 1. Samsun Tuberculosis Dispensary of Health Directorate, Samsun, Turkey. 2. Department of Public Health, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey. 3. Departman of Pathology, Gazi Hospital, Samsun, Turkey. 4. Department Of Chest Diseases, Faculty of Çapa Medicine, İstanbul University, İstanbul, Turkey.
Abstract
OBJECTIVE: Granulomatous inflammation showing "caseification necrosis" is considered pathognomonic for tuberculosis. This study aimed to evaluate patients with granulomatous inflammation and some characteristics to diagnose tuberculosis. MATERIAL AND METHODS: This is a cross-sectional descriptive study. The study includes all pathology laboratories in Samsun between the years 2012 and 2017. Pathology reports that contained the term granulomatous were selected between all patient reports of these laboratories. The patient reports were examined by comparing the dispensary records and the presence of a diagnosis of tuberculosis. RESULTS: In the 703 pathology reports, it was found that 38% were only granulomatous and 33% were caseous granulomatosis lesions. When the prevalence of tuberculosis according to the presence of microscopic necrosis was observed in granulomatous tissue samples, 85% tuberculosis was found in patients with necrotic granulomatous tissue and 14% tuberculosis was found with non-necrotic lesions. The presence of tuberculosis in necrotic granulomatous tissues was statistically significantly higher (P < .00001). CONCLUSION: As a result, when examining a pathology report for the presence of tuberculosis, the existence of a granulomatous reaction should be considered first. Getting stuck on the definition of caseification necrosis will cause the case to be skipped. An indication of necrosis in the pathologic evaluation will guide the diagnosis of tuberculosis.
OBJECTIVE: Granulomatous inflammation showing "caseification necrosis" is considered pathognomonic for tuberculosis. This study aimed to evaluate patients with granulomatous inflammation and some characteristics to diagnose tuberculosis. MATERIAL AND METHODS: This is a cross-sectional descriptive study. The study includes all pathology laboratories in Samsun between the years 2012 and 2017. Pathology reports that contained the term granulomatous were selected between all patient reports of these laboratories. The patient reports were examined by comparing the dispensary records and the presence of a diagnosis of tuberculosis. RESULTS: In the 703 pathology reports, it was found that 38% were only granulomatous and 33% were caseous granulomatosis lesions. When the prevalence of tuberculosis according to the presence of microscopic necrosis was observed in granulomatous tissue samples, 85% tuberculosis was found in patients with necrotic granulomatous tissue and 14% tuberculosis was found with non-necrotic lesions. The presence of tuberculosis in necrotic granulomatous tissues was statistically significantly higher (P < .00001). CONCLUSION: As a result, when examining a pathology report for the presence of tuberculosis, the existence of a granulomatous reaction should be considered first. Getting stuck on the definition of caseification necrosis will cause the case to be skipped. An indication of necrosis in the pathologic evaluation will guide the diagnosis of tuberculosis.
Authors: Sanjay Mukhopadhyay; Carol F Farver; Laszlo T Vaszar; Owen J Dempsey; Helmut H Popper; Haresh Mani; Vera L Capelozzi; Junya Fukuoka; Keith M Kerr; E Handan Zeren; Venkateswaran K Iyer; Tomonori Tanaka; Ivy Narde; Angheliki Nomikos; Derya Gumurdulu; Sudheer Arava; Dani S Zander; Henry D Tazelaar Journal: J Clin Pathol Date: 2011-10-19 Impact factor: 3.411