Cuma Bülent Gül1, Mehmet Küçük2, Savaş Öztürk3, Erol Demir4, Necmi Eren5, Abdullah Şumnu6, Nurhan Seyahi7, Mustafa Güllülü8, Fatih Dede9, Ülver Derici10, Yener Koç11, Garip Şahin12, Oktay Oymak13, Gülizar Manga Sahin14, Erhan Tatar15, Belda Dursun16, Hamad Dheir17, Süheyla Apaydın18, Gültekin Süleymanlar19, Sena Ulu20, Orçun Altınören21, Sim Kutlay22, Meral Meşe23, İdris Şahin24, Sedat Üstündağ25, Kültigin Türkmen26, Mehmet Emin Yılmaz27, Rümeyza Turan Kazancıoğlu28, Özcan Uzun29, Ferhan Candan30, Zeki Aydın31, Deren Oygar32, Nimet Aktaş33, Yunus Erdem34, Saime Paydaş35, Dilek Taymez36, Başak Can2, Ahmet Kıykım37, Leyla Koç38, Siren Sezer39, Murat Duranay40, Simge Bardak41, Lütfullah Altıntepe42, Burcu Kaya43, Alper Azak44, Sebahat Alışır Ecder45, Caner Çavdar29, Nedim Yılmaz Selçuk26. 1. Department of Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. cumabulentgul@gmail.com. 2. Nephrology, Okmeydanı Training and Research Hospital, Istanbul, Turkey. 3. Nephrology, Haseki Training and Resarch Hospital, Istanbul, Turkey. 4. Nephrology, Istanbul University Medical School, Istanbul, Turkey. 5. Nephrology, Kocaeli University School of Medicine, Kocaeli, Turkey. 6. Faculty of Medicine, Nephrology, Medipol University Hospital, Istanbul, Turkey. 7. Nephrology, Cerrahpasa University Medical School, Istanbul, Turkey. 8. Nephrology, Uludag University Medical Faculty Hospital, Bursa, Turkey. 9. Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey. 10. Nephrology, Gazi University Medical Faculty, Ankara, Turkey. 11. Nephrology, Sisli Hamidiye Training and Research Hospital, Istanbul, Turkey. 12. Nephrology, Osmangazi University, Odunpazarı, Eskisehir, Turkey. 13. Nephrology, Erciyes University, Kayseri, Turkey. 14. Nephrology, Sultan Abdülhamid Han Training and Research Hospital, Istanbul, Turkey. 15. Nephrology, Bozyaka Training and Research Hospital, Izmir, Turkey. 16. Nephrology, Pamukkale University, Denizli, Turkey. 17. Nephrology, Sakarya Training and Research Hospital, Sakarya, Turkey. 18. Istanbul Sadi Konuk Training and Research Hospital, Istanbul, Turkey. 19. Nephrology, Akdeniz University Hospital, Antalya, Turkey. 20. Nephrology, Afyon Kocatepe University Medical School, Afyonkarahisar, Turkey. 21. Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. 22. Faculty of Medicine, Nephrology, Ankara University, Ankara, Turkey. 23. Nephrology, Istanbul Dr Lufti Kirdar Kartal Training and Research Hospital, Istanbul, Turkey. 24. Nephrology, Inonu University Medical School, Malatya, Turkey. 25. Nephrology, Trakya University Medical School, Edirne, Turkey. 26. Nephrology, Necmettin Erbakan University Meram Medical School, Konya, Turkey. 27. Nephrology, Dicle University Medical School, Diyarbakir, Turkey. 28. Nephrology, Bezmialem University Medical School, Istanbul, Turkey. 29. Nephrology, Dokuz Eylul University Medical School, Izmir, Turkey. 30. Nephrology, Cumhuriyet University Medical School, Sivas, Turkey. 31. Nephrology, Darıca Farabi Training and Research Hospital, Kocaeli, Turkey. 32. Nephrology, Lefkosa Burhan Nalbantoglu Hospital, Lefkosa, Turkish Republic of Northern Cyprus. 33. Department of Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. 34. Nephrology, Hacettepe University Medical School, Ankara, Turkey. 35. Nephrology, Cukurova University Medical School, Adana, Turkey. 36. Nephrology, Kocaeli State Hospital, Kocaeli, Turkey. 37. Nephrology, Mersin University Medical School, Mersin, Turkey. 38. Nephrology, Taksim Training and Research Hospital, Istanbul, Turkey. 39. Nephrology, Baskent University Medical School, Ankara, Turkey. 40. Nephrology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey. 41. Nephrology, Batman State Hospital, Batman, Turkey. 42. Nephrology, Selcuk University Selcuklu Medical School, Konya, Turkey. 43. Nephrology, Marmara University Medical School, Istanbul, Turkey. 44. Nephrology, Balıkesir Training and Research Hospital, Balikesir, Turkey. 45. Nephrology, Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.
Abstract
BACKGROUND: Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. METHODS: Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013-2017, and 2017-current. RESULTS: A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. CONCLUSIONS: In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.
BACKGROUND: Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. METHODS: Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013-2017, and 2017-current. RESULTS: A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. CONCLUSIONS: In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.