Abdullah Sumnu1, Kultigin Turkmen2, Egemen Cebeci3, Aydin Turkmen4, Necmi Eren5, Nurhan Seyahi6, Aysegul Oruc7, Fatih Dede8, Ülver Derici9, Taner Basturk10, Garip Şahin11, Murat Sipahioglu12, Gulizar Manga Sahin13, Erhan Tatar14, Belda Dursun15, Savas Sipahi16, Mürvet Yılmaz17, Gultekin Suleymanlar18, Sena Ulu19, Ozkan Gungor20, Sim Kutlay21, Zerrin Bicik Bahçebaşı22, İdris Sahin23, Ilhan Kurultak24, Can Sevinc25, Zulfikar Yilmaz26, Rumeyza Turan Kazancioglu27, Caner Cavdar28, Ferhan Candan29, Zeki Aydin30, Deren Oygar31, Bulent Gul32, Bulent Altun33, Saime Paydas34, Sami Uzun3, Zulal Istemihan35, Metin Ergul5, Mevlut Tamer Dincer6, Mustafa Gullulu7, Serhan Piskinpasa8, Omer Faruk Akcay9, Abdulkadir Unsal10, Sumeyra Koyuncu12, Mahmut Gok13, Savas Ozturk3. 1. Department of Nephrology, Medical Faculty, Medipol Mega Hastanesi, Medipol University, Göztepe Mahallesi Metin Sk. No: 4, Bağcılar, Istanbul, Turkey. abdullahsumnu@yahoo.com. 2. Nephrology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey. 3. Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey. 4. Nephrology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. 5. Nephrology Medical Faculty, Kocaeli University, İzmit, Kocaeli, Turkey. 6. Nephrology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. 7. Nephrology, Medical Faculty, Uludag University, Bursa, Turkey. 8. Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey. 9. Nephrology, Medical Faculty, Gazi University, Ankara, Turkey. 10. Nephrology, Hamidiye Sisli Etfal Training and Research Hospital, Istanbul, Turkey. 11. Nephrology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey. 12. Nephrology, Medical Faculty, Erciyes University, Kayseri, Turkey. 13. Nephrology, Sultan Abdulhamit Han Research and Training Hospital, Istanbul, Turkey. 14. Nephrology, Bozyaka Training and Research Hospital, Izmır, Turkey. 15. Nephrology, Medical Faculty, Pamukkale University, Denizli, Turkey. 16. Nephrology, Medical Faculty, Sakarya University, Sakarya, Turkey. 17. Nephrology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey. 18. Nephrology, Medical Faculty, Akdeniz University, Antalya, Turkey. 19. Nephrology, Medical Faculty, Afyon University, Afyon, Turkey. 20. Nephrology, Medical Faculty, Sutcu İmam University, Kahramanmaras, Turkey. 21. Nephrology, İbni Sina Hospital, Medical Faculty, Ankara University, Ankara, Turkey. 22. Nephrology, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey. 23. Nephrology, Medical Faculty, Inonu University, Malatya, Turkey. 24. Nephrology, Medical Faculty, Trakya University, Edirne, Turkey. 25. Nephrology, Medical Faculty, Ataturk University, Erzurum, Turkey. 26. Dicle University, Diyarbakir, Turkey. 27. Nephrology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey. 28. Nephrology, Medical Faculty, Dokuz Eylul University, Izmir, Turkey. 29. Nephrology, Medical Faculty, Cumhuriyet University, Sivas, Turkey. 30. Nephrology, Darica Farabi Training and Research Hospital, Darıca, Kocaeli, Turkey. 31. Nephrology, Burhan Nalbantoglu State Hospital, Lefkosa, Cyprus. 32. Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, Nilüfer, Bursa, Turkey. 33. Nephrology, Medical Faculty, Hacettepe University, Ankara, Turkey. 34. Nephrology, Medical Faculty, Cukurova University, Adana, Turkey. 35. Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Abstract
PURPOSE: Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. METHODS: Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. RESULTS: Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). CONCLUSION: This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.
PURPOSE:Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. METHODS: Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. RESULTS: Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood ureanitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). CONCLUSION: This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.