Brenda L Plassman1,2,3, Marianne Chanti-Ketterl1,3, Carl F Pieper3,4, Kristine Yaffe5. 1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA. 2. Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA. 3. Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA. 4. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA. 5. Departments of Psychiatry and Behavioral Sciences, Neurology and Epidemiology and Biostatistics, San Francisco and San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, USA.
Abstract
INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-National Research Council's Twins Registry of World War II male veterans were assigned a cognitive outcome based on a multi-step assessment protocol. History of TBI was obtained via interviews. RESULTS: Among 8302 individuals, risk of non-Alzheimer's disease (non-AD) dementia was higher in those with TBI (hazard ratio [HR] = 2.00, 95% confidence interval [CI], 0.97-4.12), than for AD (HR = 1.23, 95% CI, 0.76-2.00). To add more control of genetic and shared environmental factors, we analyzed 100 twin pairs discordant for both TBI and dementia onset, and found TBI-associated risk for non-AD dementia increased further (McNemar odds ratio = 2.70; 95% CI, 1.27-6.25). DISCUSSION: These findings suggest that non-AD mechanisms may underlie the association between TBI and dementia, potentially providing insight into inconsistent results from prior studies.
INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-National Research Council's Twins Registry of World War II male veterans were assigned a cognitive outcome based on a multi-step assessment protocol. History of TBI was obtained via interviews. RESULTS: Among 8302 individuals, risk of non-Alzheimer's disease (non-AD) dementia was higher in those with TBI (hazard ratio [HR] = 2.00, 95% confidence interval [CI], 0.97-4.12), than for AD (HR = 1.23, 95% CI, 0.76-2.00). To add more control of genetic and shared environmental factors, we analyzed 100 twin pairs discordant for both TBI and dementia onset, and found TBI-associated risk for non-AD dementia increased further (McNemar odds ratio = 2.70; 95% CI, 1.27-6.25). DISCUSSION: These findings suggest that non-AD mechanisms may underlie the association between TBI and dementia, potentially providing insight into inconsistent results from prior studies.
Authors: J Julien; S Joubert; M-C Ferland; L C Frenette; M M Boudreau-Duhaime; L Malo-Véronneau; E de Guise Journal: Ann Phys Rehabil Med Date: 2017-05-11
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