AIMS: To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes. METHODS: Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. RESULTS: The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. CONCLUSIONS: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes.
AIMS: To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes. METHODS: Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. RESULTS: The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. CONCLUSIONS: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes.
Authors: P W Schofield; M Tang; K Marder; K Bell; G Dooneief; M Chun; M Sano; Y Stern; R Mayeux Journal: J Neurol Neurosurg Psychiatry Date: 1997-02 Impact factor: 10.154
Authors: Tommy Saing; Malcolm Dick; Peter T Nelson; Ronald C Kim; David H Cribbs; Elizabeth Head Journal: J Neurotrauma Date: 2012-04-10 Impact factor: 5.269
Authors: John C Morris; Sandra Weintraub; Helena C Chui; Jeffrey Cummings; Charles Decarli; Steven Ferris; Norman L Foster; Douglas Galasko; Neill Graff-Radford; Elaine R Peskind; Duane Beekly; Erin M Ramos; Walter A Kukull Journal: Alzheimer Dis Assoc Disord Date: 2006 Oct-Dec Impact factor: 2.703
Authors: Peter T Nelson; Gregory A Jicha; Frederick A Schmitt; Huaichen Liu; Daron G Davis; Marta S Mendiondo; Erin L Abner; William R Markesbery Journal: J Neuropathol Exp Neurol Date: 2007-12 Impact factor: 3.685
Authors: Kristen Dams-O'Connor; Laura E Gibbons; James D Bowen; Susan M McCurry; Eric B Larson; Paul K Crane Journal: J Neurol Neurosurg Psychiatry Date: 2012-11-21 Impact factor: 10.154
Authors: E Julia Chosy; Noele Gross; Marnie Meyer; Catherine Y Liu; Steven D Edland; Lenore J Launer; Lon R White Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Paul K Crane; Laura E Gibbons; Kristen Dams-O'Connor; Emily Trittschuh; James B Leverenz; C Dirk Keene; Joshua Sonnen; Thomas J Montine; David A Bennett; Sue Leurgans; Julie A Schneider; Eric B Larson Journal: JAMA Neurol Date: 2016-09-01 Impact factor: 18.302
Authors: Taylor J Krivanek; Seth A Gale; Brittany M McFeeley; Casey M Nicastri; Kirk R Daffner Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Erin L Abner; Peter T Nelson; Gregory A Jicha; Gregory E Cooper; David W Fardo; Frederick A Schmitt; Richard J Kryscio Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Adam D Bachstetter; Eseosa T Ighodaro; Yasmin Hassoun; Danah Aldeiri; Janna H Neltner; Ela Patel; Erin L Abner; Peter T Nelson Journal: Neurobiol Aging Date: 2017-01-05 Impact factor: 4.673
Authors: Christian LoBue; David Denney; Linda S Hynan; Heidi C Rossetti; Laura H Lacritz; John Hart; Kyle B Womack; Fu L Woon; C Munro Cullum Journal: J Alzheimers Dis Date: 2016 Impact factor: 4.472
Authors: David Tweedie; Lital Rachmany; Vardit Rubovitch; Yazhou Li; Harold W Holloway; Elin Lehrmann; Yongqing Zhang; Kevin G Becker; Evelyn Perez; Barry J Hoffer; Chaim G Pick; Nigel H Greig Journal: Alzheimers Dement Date: 2015-08-29 Impact factor: 21.566